Paper · 12372426

TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.

Sakurai H and 5 others. Biochem Biophys Res Commun, 2002. Cited by 74 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. Papers, record 12372426. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12372426

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways.; PubMed
Journal: Biochem Biophys Res Commun; PubMed
Year: 2002; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/12372426/; PubMed
DOI: https://doi.org/10.1016/s0006-291x(02)02379-3; PubMed
The journal: https://conductscience.org/library/journal-index/0372516; PubMed
Citations, by iCite: 74; iCite
Relative citation ratio, by iCite: 1.2; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Sakurai H	Hiroaki
2	Nishi A	Akito
3	Sato N	Naoya
4	Mizukami J	Junko
5	Miyoshi H	Hidetaka
6	Sugita T	Takahisa

Source PubMed

Topics26

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Adaptor Proteins, Signal Transducing	Major topic
Carrier Proteins	Major topic
Intracellular Signaling Peptides and Proteins	Major topic
MAP Kinase Kinase Kinases	Major topic
NF-kappa B	Major topic
Transcription Factor AP-1	Major topic
Binding Sites
Blotting, Western
DNA, Complementary
Enzyme-Linked Immunosorbent Assay
HeLa Cells
Humans
Interleukin-6
Interleukin-8
JNK Mitogen-Activated Protein Kinases
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases
Models, Genetic
Mutation
Precipitin Tests
Protein Binding
Protein Structure, Tertiary
Recombinant Fusion Proteins
Transfection
p38 Mitogen-Activated Protein Kinases
MAP Kinase Kinase Kinase 7

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by35

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.

PMID	Title	Journal	Year	In Papers	Source
41,581,886	The stress-activated kinase p38 mediates non-canonical activation of Src and tyrosine phosphorylation of the adapter protein TAB1.	J Biol Chem	2026	https://conductscience.org/library/papers/41581886	PubMed
37,733,743	Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.	Proc Natl Acad Sci U S A	2023	https://conductscience.org/library/papers/37733743	PubMed
37,154,023	EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell.	Mol Cell Biol	2023	https://conductscience.org/library/papers/37154023	PubMed
35,459,245	Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.	Nat Commun	2022	https://conductscience.org/library/papers/35459245	PubMed
34,504,651	Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.	Oncotarget	2021	https://conductscience.org/library/papers/34504651	PubMed
33,677,092	mRNA-encoded, constitutively active STINGV155M is a potent genetic adjuvant of antigen-specific CD8+ T cell response.	Mol Ther	2021	https://conductscience.org/library/papers/33677092	PubMed
33,327,533	TXNIP Regulates Natural Killer Cell-Mediated Innate Immunity by Inhibiting IFN-γ Production during Bacterial Infection.	Int J Mol Sci	2020	https://conductscience.org/library/papers/33327533	PubMed
32,873,150	TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases.	Open Biol	2020	https://conductscience.org/library/papers/32873150	PubMed
31,549,767	A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.	Pigment Cell Melanoma Res	2020	https://conductscience.org/library/papers/31549767	PubMed
31,214,512	The MAP3K7-mTOR Axis Promotes the Proliferation and Malignancy of Hepatocellular Carcinoma Cells.	Front Oncol	2019	https://conductscience.org/library/papers/31214512	PubMed

1 to 10 of 35

See all 35 cited by

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
IL6	3,569	PubTator's text mining	https://conductscience.org/library/genes/3569	NCBI Gene
JUN	3,725	PubTator's text mining	https://conductscience.org/library/genes/3725	NCBI Gene
MAP3K7	6,885	PubTator's text mining	https://conductscience.org/library/genes/6885	NCBI Gene
NFKB1	4,790	PubTator's text mining	https://conductscience.org/library/genes/4790	NCBI Gene
TAB1	10,454	PubTator's text mining	https://conductscience.org/library/genes/10454	NCBI Gene
WNK2	65,268	PubTator's text mining	https://conductscience.org/library/genes/65268	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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