Paper · 12688310
High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.
Feller SM and 2 others. Leuk Lymphoma, 2003. Cited by 20 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia. Papers, record 12688310. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/12688310
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.
- PubMed
Topics29
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Adaptor Proteins, Signal Transducing | Major topic |
| Antineoplastic Agents | Major topic |
| Fusion Proteins, bcr-abl | Major topic |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Major topic |
| Neoplasm Proteins | Major topic |
| Proteins | Major topic |
| Animals | |
| Antineoplastic Combined Chemotherapy Protocols | |
| Benzamides | |
| Drug Design | |
| Enzyme Inhibitors | |
| Fatty Acids, Unsaturated | |
| Forecasting | |
| GRB2 Adaptor Protein | |
| Humans | |
| Imatinib Mesylate | |
| Macromolecular Substances | |
| Mice | |
| Peptide Fragments | |
| Phosphatidylinositol 3-Kinases | |
| Piperazines | |
| Protein Binding | |
| Pyrimidines | |
| Signal Transduction | |
| Son of Sevenless Proteins | |
| Structure-Activity Relationship | |
| Transcription Factors | |
| ras Proteins | |
| src Homology Domains |
Source PubMed
Grants0
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None in this release.
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References0
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
None in this release.
Cited by6
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 20 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,979,455 | The conformational-condensate code of GRB2: State switching, spatial organization, and therapeutic windows. | Acta Pharm Sin B | 2026 | https://conductscience.org/library/papers/42979455 | PubMed |
| 39,175,664 | GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease. | Biochem Biophys Rep | 2024 | https://conductscience.org/library/papers/39175664 | PubMed |
| 38,533,261 | Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology. | Front Pharmacol | 2024 | https://conductscience.org/library/papers/38533261 | PubMed |
| 30,210,578 | Insights into the Shc Family of Adaptor Proteins. | J Mol Signal | 2017 | https://conductscience.org/library/papers/30210578 | PubMed |
| 21,072,043 | Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. | Leukemia | 2011 | https://conductscience.org/library/papers/21072043 | PubMed |
| 18,620,523 | Grb2 signaling in cell motility and cancer. | Expert Opin Ther Targets | 2008 | https://conductscience.org/library/papers/18620523 | PubMed |
Genes4
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ABL1 | 25 | PubTator's text mining | https://conductscience.org/library/genes/25 | NCBI Gene |
| BCR | 613 | PubTator's text mining | https://conductscience.org/library/genes/613 | NCBI Gene |
| GRB2 | 2,885 | PubTator's text mining | https://conductscience.org/library/genes/2885 | NCBI Gene |
| XYLT2 | 64,132 | PubTator's text mining | https://conductscience.org/library/genes/64132 | NCBI Gene |
Drugs0
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None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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