Paper · 15902208
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Oltersdorf T and 32 others. Nature, 2005. Cited by 2,873 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Papers, record 15902208. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/15902208
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics23
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Antineoplastic Agents | Major topic |
| Biphenyl Compounds | Major topic |
| Neoplasms | Major topic |
| Proto-Oncogene Proteins c-bcl-2 | Major topic |
| Animals | |
| Apoptosis | |
| Carcinoma, Small Cell | |
| Cell Line, Tumor | |
| Cytochromes c | |
| Disease Models, Animal | |
| Drug Synergism | |
| Humans | |
| Lymphoma | |
| Magnetic Resonance Spectroscopy | |
| Mice | |
| Mitochondria | |
| Models, Molecular | |
| Nitrophenols | |
| Paclitaxel | |
| Piperazines | |
| Structure-Activity Relationship | |
| Sulfonamides | |
| Survival Rate |
Source PubMed
Grants0
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
None in this release.
Trials1
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
| Trial | Title | The trial lists it as | Named in the paper's record |
|---|---|---|---|
| NCT02384083 | Filanesib (ARRY-520) in Combination With Pomalidomide and Dexamethasone for Relapsed/Refractory (R/R) Multiple Myeloma (MM) Patients | Results |
Source ClinicalTrials.gov
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References0
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
None in this release.
Cited by1,642
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,873 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,855,459 | C2ORF68 stabilizes SIVA1 to upregulate BCL-2 and suppress apoptosis in gallbladder cancer. | Cell Death Discov | 2026 | https://conductscience.org/library/papers/42855459 | PubMed |
| 42,794,479 | Balancing Ubiquitination and Deubiquitination in Apoptotic Protein Stability and Cancer Cell Survival. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/42794479 | PubMed |
| 42,776,347 | Overcoming ABT-737 resistance in triple-negative breast cancer: C-phycocyanin-mediated myeloid cell leukemia-1 downregulation enhances apoptotic sensitivity. | Mol Biol Rep | 2026 | https://conductscience.org/library/papers/42776347 | PubMed |
| 42,737,465 | NMR Studies on Protein-Ligand Interactions. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/42737465 | PubMed |
| 42,687,020 | The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death. | Cell Mol Immunol | 2026 | https://conductscience.org/library/papers/42687020 | PubMed |
| 42,684,521 | Protein-protein interactions as therapeutic targets in breast cancer: integrated computational and experimental advances, mechanisms and clinical translation. | Mol Biol Rep | 2026 | https://conductscience.org/library/papers/42684521 | PubMed |
| 42,588,710 | Rewiring of the Apoptotic Rheostat in HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma. | Cancers (Basel) | 2026 | https://conductscience.org/library/papers/42588710 | PubMed |
| 42,524,598 | Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases. | Int J Biol Sci | 2026 | https://conductscience.org/library/papers/42524598 | PubMed |
| 42,512,967 | Effects of BCL-2 and MCL-1 Inhibition on Apoptotic and Transcriptional Profiles in Acute Myeloid Leukemia. | Medicina (Kaunas) | 2026 | https://conductscience.org/library/papers/42512967 | PubMed |
| 42,505,417 | Necroptosis: The Regulation Between EGFR and TNFR in Cancer. | Cells | 2026 | https://conductscience.org/library/papers/42505417 | PubMed |
1 to 10 of 1,642
See all 1,642 cited byGenes3
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| BCL2 | 596 | Swiss-Prot's references | https://conductscience.org/library/genes/596 | NCBI Gene |
| BCL2L1 | 598 | Swiss-Prot's references | https://conductscience.org/library/genes/598 | NCBI Gene |
| BCL2L2 | 599 | PubTator's text mining | https://conductscience.org/library/genes/599 | NCBI Gene |
Drugs3
The drugs whose trials, in the Pipelines release, list the paper.
| Drug | ChEMBL ID | The trials list it as | Trials | In Drugs and targets | Source |
|---|---|---|---|---|---|
| FILANESIB | CHEMBL2347655 | Results | 1 | https://conductscience.org/library/drugs/CHEMBL2347655 | ChEMBL |
| DEXAMETHASONE | CHEMBL384467 | Results | 1 | https://conductscience.org/library/drugs/CHEMBL384467 | ChEMBL |
| POMALIDOMIDE | CHEMBL43452 | Results | 1 | https://conductscience.org/library/drugs/CHEMBL43452 | ChEMBL |
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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