Drug · CHEMBL384467

DEXAMETHASONE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. DEXAMETHASONE. Drugs and targets, record CHEMBL384467. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL384467

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: DEXAMETHASONE; ChEMBL
ChEMBL ID: CHEMBL384467; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Aeroseb-dex, Decaderm, Decadron, Decadron-75, Decaspray, Dexa-sine, Dexacortal, Dexacortin, Dexacortisyl, Dexafree, Dexamethasone component of ciprodex, Dexamethasone component of dexacidin, Dexamethasone component of dexasporin, Dexamethasone component of maxitrol, Dexamethasone component of tobradex, Dexamethasone component of tobradex st, Dexamethasone intensol, Dexamonozon, Dexapos, Dexasite, Dexasone, Dexone, Dexone 0.5, Dexone 0.75, Dexone 1.5, Dexone 4, Dexsol, Dextenza, Dexycu kit, Dropodex, Fortecortin, Gppe ear spy, Hemady, Hexadrol, Isopto-dex, Kortico injection, Loverine, Luxazone, Martapan, Maxidex, Maxitrol, Oradexon, Otomize, Ozurdex, Sofradex, Spersadex comp, Tobradex; ChEMBL
Other names: Dexametasona, Dexamethasone metasulfobenzoate sodium, Dexamethasone palmitate, Dexamethasone valerate, Dexycu, Fluormethylprednisolone, ISV-305, Mymethasone, NSC-34521, Neodecadron, OTO-104; ChEMBL
DrugBank: DB01234; DrugBank
InChIKey: UREBDLICKHMUKA-CXSFZGCWSA-N; ChEMBL
Open Targets' highest stage: Approval, for 75 of its 445 diseases, from ATC, ClinicalTrials.gov, DailyMed, EMA Human Drugs, PMDA and TTD; Open Targets

Targets1

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
NR3C1	Glucocorticoid receptor	Glucocorticoid receptor agonist	AGONIST	https://conductscience.org/library/genes/2908

Source ChEMBL

Diseases445

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
plasma cell myeloma	Approval	ClinicalTrials.gov, EMA Human Drugs and PMDA	856	852	https://conductscience.org/library/drugs?q=MONDO_0009693
acute lymphoblastic leukemia	Phase 3	ClinicalTrials.gov	168	168	https://conductscience.org/library/drugs?q=MONDO_0004967
non-Hodgkin lymphoma	Phase 3	ClinicalTrials.gov	56	56	https://conductscience.org/library/drugs?q=MONDO_0018908
autoimmune thrombocytopenic purpura	Approval	DailyMed	50	43	https://conductscience.org/library/drugs?q=MONDO_0008558
diabetic macular edema	Phase 3	ClinicalTrials.gov	39	39	https://conductscience.org/library/drugs?q=MONDO_0004728
macular retinal edema	Approval	DailyMed and EMA Human Drugs	38	36	https://conductscience.org/library/drugs?q=MONDO_0003005
Pain	Phase 3	ClinicalTrials.gov	32	32	https://conductscience.org/library/drugs?q=HP_0012531
diffuse large B-cell lymphoma	Phase 3	ClinicalTrials.gov	31	31	https://conductscience.org/library/drugs?q=MONDO_0018905
mantle cell lymphoma	Phase 3	ClinicalTrials.gov	31	31	https://conductscience.org/library/drugs?q=MONDO_0018876
COVID-19	Phase 3	ClinicalTrials.gov	30	30	https://conductscience.org/library/drugs?q=MONDO_0100096

1 to 10 of 445Source Open Targets

See all 445 diseases

Trials3,105

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 9 more rest on that reading alone and are shown because the trials' posted result groups or NLM's indexing of their papers name the drug. 397 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT02625181	Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis		27,034	2019-03-07	dexamethasone	Its name	ClinicalTrials.gov
NCT01190930	Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma	Phase 3	9,350	2020-06-23	dexamethasone	Its name	ClinicalTrials.gov
NCT02883049	Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations	Phase 3	5,949	2024-03-12	dexamethasone	Its name	ClinicalTrials.gov
NCT00103285	Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia	Phase 3	5,377	2018-07-11	dexamethasone	Its name	ClinicalTrials.gov
NCT00075725	Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia	Phase 3	3,154	2015-08-06	dexamethasone	Its name	ClinicalTrials.gov
NCT00179647	Expanded Access Program:Lenalidomide With or Without Dexamethasone In Previously Treated Subjects With Multiple Myeloma	Phase 3	1,913	2010-03-03	dexamethasone	Its name	ClinicalTrials.gov
NCT00408005	Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma	Phase 3	1,895	2019-06-20	dexamethasone	Its name	ClinicalTrials.gov
NCT00025259	Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease	Phase 3	1,734	2017-03-07	dexamethasone	Its name	ClinicalTrials.gov
NCT00689936	Study to Determine Efficacy and Safety of Lenalidomide Plus Low-dose Dexamethasone Versus Melphalan, Prednisone, Thalidomide in Patients With Previously Untreated Multiple Myeloma	Phase 3	1,623	2017-08-11	dexamethasone	Its name	ClinicalTrials.gov
NCT00343460	APF530 or Aloxi (Palonosetron Hydrochloride) Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer	Phase 3	1,428	2016-12-28	dexamethasone	Its name	ClinicalTrials.gov

1 to 10 of 3,105

See all 3,105 trials

Comparisons in its trials740

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
All Patients for Induction, MRD Negative vs All Patients for Induction, MRD Positive: Early Marrow Status (EMS) by MRD Status End Induction (Day 29)	4,378 of 4,609	258 of 362	4,971	NCT00103285	Trial comparisons
Rolapitant + Granisetron + Dexamethasone vs Placebo + Granisetron + Dexamethasone: serious adverse events	89 of 670	103 of 674	1,344	NCT01500226	Trial comparisons
Arm A Part 1 vs Arm B Part 1: Post-Consolidation Stringent Complete Response (sCR) Rate	110 of 542	157 of 543	1,085	NCT02541383	Trial comparisons
Rescue Course of Betamethasone or Dexamethasone vs Placebo (Normal Saline): serious adverse events	40 of 512	41 of 502	1,014	NCT00201643	Trial comparisons
Remdesivir Plus Baricitinib vs Remdesivir Plus Dexamethasone: deaths from any cause	28 of 516	34 of 494	1,010	NCT04640168	Trial comparisons
Fosaprepitant Regimen vs Control Regimen: serious adverse events	39 of 504	35 of 497	1,001	NCT01594749	Trial comparisons
Remdesivir Plus Baricitinib vs Remdesivir Plus Dexamethasone: serious adverse events	95 of 503	94 of 482	985	NCT04640168	Trial comparisons
Bortezomib vs Carfilzomib: serious adverse events	182 of 456	272 of 463	919	NCT01568866	Trial comparisons
APF530 + Fosaprepitant + Dexamethasone vs Ondansetron + Fosaprepitant + Dexamethasone: serious adverse events	42 of 456	28 of 459	915	NCT02106494	Trial comparisons
Levofloxacin + Dexamethasone Followed by Dexamethasone vs Tobramycin + Dexamethasone: deaths from any cause	1 of 395	0 of 393	788	NCT03739528	Trial comparisons

1 to 10 of 740

See all 740 comparisons in its trials

Papers from its trials1,898

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
41714853	RESULT	1	PubMed
40886716	RESULT	1	PubMed
40383127	RESULT	1	PubMed
40360262	RESULT	1	PubMed
40261382	RESULT	1	PubMed
40181005	RESULT	1	PubMed
40009371	RESULT	1	PubMed
39911261	RESULT	1	PubMed
39819928	RESULT	1	PubMed
39709396	RESULT	1	PubMed

1 to 10 of 1,898

See all 1,898 papers from its trials

Tests in its trials7

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	Source
Psychomotor Vigilance Task	3	ConductCognition
Sternberg Memory Scanning	2	ConductCognition
1-Back Task	1	ConductCognition
2-Back Task	1	ConductCognition
Stroop Color-Word Test	1	ConductCognition
Trail Making Test A	1	ConductCognition
Trail Making Test B	1	ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL384467

GET https://conductscience.org/api/drugs/v1/CHEMBL384467/diseases?page=2

API reference For AI assistants