Paper · 18445007

Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6.

Cognasse F and 6 others. Immunology, 2008. Cited by 35 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Papers, record 18445007. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/18445007

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6.; PubMed
Journal: Immunology; PubMed
Year: 2008; PubMed
Publication types: Journal Article, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/18445007/; PubMed
DOI: https://doi.org/10.1111/j.1365-2567.2008.02844.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2669146/; PubMed
The journal: https://conductscience.org/library/journal-index/0374672; PubMed
Citations, by iCite: 35; iCite
Relative citation ratio, by iCite: 0.67; iCite
Revised in PubMed: 2021-10-20; PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Cognasse F	Fabrice
2	Hamzeh-Cognasse H	Hind
3	Lafarge S	Sandrine
4	Chavarin P	Patricia
5	Pozzetto B	Bruno
6	Richard Y	Yolande
7	Garraud O	Olivier

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocyte Subsets	Major topic
Interleukin-6	Major topic
Toll-Like Receptor 9	Major topic
B7-1 Antigen
Cell Membrane
Cells, Cultured
CpG Islands
Humans
Immunologic Memory
Lymphocyte Activation
Receptors, IgE
Tumor Necrosis Factor Receptor Superfamily, Member 7

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References48

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	17,621,369	TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.	Eur J Immunol	2007	https://conductscience.org/library/papers/17621369	PubMed
2	17,000,899	Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19.	J Leukoc Biol	2006	https://conductscience.org/library/papers/17000899	PubMed
3	15,698,512	Differential downstream effects of CD40 ligation mediated by membrane or soluble CD40L and agonistic Ab: a study on purified human B cells.	Int J Immunopathol Pharmacol	2005	https://conductscience.org/library/papers/15698512	PubMed
4	18,178,818	CpG drives human transitional B cells to terminal differentiation and production of natural antibodies.	J Immunol	2008	https://conductscience.org/library/papers/18178818	PubMed
5	14,707,068	IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.	J Immunol	2004	https://conductscience.org/library/papers/14707068	PubMed
6	16,780,564	A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation.	Immunology	2006	https://conductscience.org/library/papers/16780564	PubMed
7	17,032,927	CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells.	Blood	2007	https://conductscience.org/library/papers/17032927	PubMed
8	12,481,138	Maintenance of serological memory by polyclonal activation of human memory B cells.	Science	2002	https://conductscience.org/library/papers/12481138	PubMed
9	11,970,999	Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.	J Immunol	2002	https://conductscience.org/library/papers/11970999	PubMed
10	16,188,245	Expression of toll-like receptors on B lymphocytes.	Cell Immunol	2005	https://conductscience.org/library/papers/16188245	PubMed

1 to 10 of 48

See all 48 references

Cited by20

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 35 citations.

PMID	Title	Journal	Year	In Papers	Source
42,384,292	Response to Commentary: Memory B Cells in Major Depressive Disorder: Toward Mechanistic and Clinical Refinement.	Curr Med Sci	2026	https://conductscience.org/library/papers/42384292	PubMed
41,528,645	Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder.	Curr Med Sci	2026	https://conductscience.org/library/papers/41528645	PubMed
39,494,905	Lipid nanoparticles as adjuvant of norovirus VLP vaccine augment cellular and humoral immune responses in a TLR9- and type I IFN-dependent pathway.	J Virol	2024	https://conductscience.org/library/papers/39494905	PubMed
34,168,647	Memory B Cells in Multiple Sclerosis: Emerging Players in Disease Pathogenesis.	Front Immunol	2021	https://conductscience.org/library/papers/34168647	PubMed
33,950,279	CpG ODN as an adjuvant arouses the vigor of B cells by relieving the negative regulation of surface TLR9 to enhance the antibody response to vaccine.	Appl Microbiol Biotechnol	2021	https://conductscience.org/library/papers/33950279	PubMed
27,812,176	Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4.	PLoS One	2016	https://conductscience.org/library/papers/27812176	PubMed
25,790,192	Expression of Toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome.	PLoS One	2015	https://conductscience.org/library/papers/25790192	PubMed
25,196,729	The CD27+ memory B cells display changes in the gene expression pattern in elderly individuals.	Immunology	2014	https://conductscience.org/library/papers/25196729	PubMed
23,194,300	Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond.	BMC Immunol	2012	https://conductscience.org/library/papers/23194300	PubMed
22,547,654	B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells.	J Exp Med	2012	https://conductscience.org/library/papers/22547654	PubMed

1 to 10 of 20

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Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
CD19	930	PubTator's text mining	https://conductscience.org/library/genes/930	NCBI Gene
CD27	939	PubTator's text mining	https://conductscience.org/library/genes/939	NCBI Gene
CD80	941	PubTator's text mining	https://conductscience.org/library/genes/941	NCBI Gene
FCER2	2,208	PubTator's text mining	https://conductscience.org/library/genes/2208	NCBI Gene
IL6	3,569	PubTator's text mining	https://conductscience.org/library/genes/3569	NCBI Gene
TLR9	54,106	PubTator's text mining	https://conductscience.org/library/genes/54106	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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