Paper · 19730150
Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma.
Park JK and 3 others. Pancreas, 2009. Cited by 243 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
Cite this record
ConductScience Library. Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Papers, record 19730150. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19730150
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics19
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Apoptosis | Major topic |
| Cell Cycle | Major topic |
| Deoxycytidine | Major topic |
| MicroRNAs | Major topic |
| Oligonucleotides, Antisense | Major topic |
| Adenocarcinoma | |
| Antimetabolites, Antineoplastic | |
| Blotting, Western | |
| Cell Line | |
| Cell Line, Tumor | |
| Cyclin-Dependent Kinase Inhibitor p21 | |
| Cyclin-Dependent Kinase Inhibitor p27 | |
| G1 Phase | |
| Humans | |
| PTEN Phosphohydrolase | |
| Pancreatic Neoplasms | |
| Reverse Transcriptase Polymerase Chain Reaction | |
| Transfection | |
| Gemcitabine |
Source PubMed
Grants1
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| CA107435 | NCI NIH HHS | United States | R21CA107435 | PubMed and NIH |
Source NIH RePORTER
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References0
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
None in this release.
Cited by154
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 243 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,870,282 | MSC-derived exosomes co-delivering anti-miR-221 and gemcitabine for inhibiting the proliferation of pancreatic cancer. | J Transl Med | 2026 | https://conductscience.org/library/papers/42870282 | PubMed |
| 42,285,304 | Stearoyl-CoA desaturase 5 (SCD5) in lipid remodeling: From molecular control to pathophysiology. | J Lipid Res | 2026 | https://conductscience.org/library/papers/42285304 | PubMed |
| 42,074,175 | MV-HAGCN: Prediction of miRNA-Disease Association Based on Multi-View Hybrid Attention Graph Convolutional Network. | Int J Mol Sci | 2026 | https://conductscience.org/library/papers/42074175 | PubMed |
| 42,072,644 | Graphene Oxide-Antisense miR-21 Nanosystem Modulates Gene Expression and Suppresses Tumorigenesis in HepG2-Derived CAM Xenografts. | Biomolecules | 2026 | https://conductscience.org/library/papers/42072644 | PubMed |
| 41,860,028 | Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review). | Int J Oncol | 2026 | https://conductscience.org/library/papers/41860028 | PubMed |
| 41,810,441 | Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance. | World J Gastroenterol | 2026 | https://conductscience.org/library/papers/41810441 | PubMed |
| 41,476,448 | Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights. | Front Mol Biosci | 2025 | https://conductscience.org/library/papers/41476448 | PubMed |
| 39,882,259 | MicroRNAs in pancreatic cancer drug resistance: mechanisms and therapeutic potential. | Front Cell Dev Biol | 2024 | https://conductscience.org/library/papers/39882259 | PubMed |
| 39,855,897 | Diagnostic and Prognostic Accuracy of MiRNAs in Pancreatic Cancer: A Systematic Review and Meta-Analysis. | J Cell Mol Med | 2025 | https://conductscience.org/library/papers/39855897 | PubMed |
| 39,200,178 | Using microRNAs Networks to Understand Pancreatic Cancer-A Literature Review. | Biomedicines | 2024 | https://conductscience.org/library/papers/39200178 | PubMed |
1 to 10 of 154
See all 154 cited byGenes7
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CDKN1A | 1,026 | PubTator's text mining | https://conductscience.org/library/genes/1026 | NCBI Gene |
| CDKN1B | 1,027 | PubTator's text mining | https://conductscience.org/library/genes/1027 | NCBI Gene |
| DCTN6 | 10,671 | PubTator's text mining | https://conductscience.org/library/genes/10671 | NCBI Gene |
| MIR21 | 406,991 | PubTator's text mining | https://conductscience.org/library/genes/406991 | NCBI Gene |
| MIR221 | 407,006 | PubTator's text mining | https://conductscience.org/library/genes/407006 | NCBI Gene |
| PTEN | 5,728 | PubTator's text mining | https://conductscience.org/library/genes/5728 | NCBI Gene |
| RECK | 8,434 | PubTator's text mining | https://conductscience.org/library/genes/8434 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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