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Paper · 19789532

Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial.

Okines A and 6 others. Br J Cancer, 2009. Cited by 124 papers, by iCite.

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ConductScience Library. Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial. Papers, record 19789532. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19789532

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Surgery with curative-intent in patients treated with first-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and the randomised phase-III NO16966 trial.
PubMed
Journal
Br J Cancer
PubMed
Year
2009
PubMed
Publication types
Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial
PubMed
Citations, by iCite
124
iCite
Relative citation ratio, by iCite
2.96
iCite
Revised in PubMed
2022-03-30
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Okines AA
2Puerto ODO Del
3Cunningham DD
4Chau II
5Van Cutsem EE
6Saltz LL
7Cassidy JJ

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Angiogenesis InhibitorsMajor topic
Antibodies, MonoclonalMajor topic
Antineoplastic Combined Chemotherapy ProtocolsMajor topic
Colorectal NeoplasmsMajor topic
Antibodies, Monoclonal, Humanized
Bevacizumab
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Neoplasm Metastasis
Postoperative Complications

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
117,442,997
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200.
J Clin Oncol2007https://conductscience.org/library/papers/17442997PubMed
214,657,227FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study.J Clin Oncol2004https://conductscience.org/library/papers/14657227PubMed
316,635,279Neoadjuvant treatment of unresectable liver metastases from colorectal cancer.Clin Colorectal Cancer2006https://conductscience.org/library/papers/16635279PubMed
415,383,792Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival.Ann Surg2004https://conductscience.org/library/papers/15383792PubMed
517,901,955Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases.Cancer Chemother Pharmacol2008https://conductscience.org/library/papers/17901955PubMed
619,339,720Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.N Engl J Med2009https://conductscience.org/library/papers/19339720PubMed
716,118,771Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab.J Surg Oncol2005https://conductscience.org/library/papers/16118771PubMed
817,353,923Safe liver resection following chemotherapy for colorectal metastases is a matter of timing.Br J Cancer2007https://conductscience.org/library/papers/17353923PubMed
911,352,309Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal.Ann Surg Oncol2001https://conductscience.org/library/papers/11352309PubMed
1012,506,171Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer.J Clin Oncol2003https://conductscience.org/library/papers/12506171PubMed

1 to 10 of 26

See all 26 references

Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 124 citations.

PMIDTitleJournalYearIn PapersSource
42,649,986Biological and Targeted Therapies in the Multidisciplinary Management of Gastrointestinal Cancers.Cancers (Basel)2026https://conductscience.org/library/papers/42649986PubMed
41,199,978Preoperative Versus Postoperative Chemotherapy With CAPOX Plus Bevacizumab for Resectable Colorectal Liver Metastases: A Randomized Phase II Trial (HiSCO-01).Ann Gastroenterol Surg2025https://conductscience.org/library/papers/41199978PubMed
39,648,217Anlotinib plus chemotherapy as a first-line treatment for gastrointestinal cancer patients with unresectable liver metastases: a multicohort, multicenter, exploratory trial.Signal Transduct Target Ther2024https://conductscience.org/library/papers/39648217PubMed
35,246,503Colorectal liver metastasis: molecular mechanism and interventional therapy.Signal Transduct Target Ther2022https://conductscience.org/library/papers/35246503PubMed
34,616,511Neoadjuvant chemotherapy for colorectal liver metastases: A contemporary review of the literature.World J Gastrointest Oncol2021https://conductscience.org/library/papers/34616511PubMed
33,220,806Debate: Improvements in Systemic Therapies for Liver Metastases Will Increase the Role of Locoregional Treatments.Surg Oncol Clin N Am2021https://conductscience.org/library/papers/33220806PubMed
33,042,471CD44 expression enhances chemoresistance and implies occult micrometastases after conversion hepatectomy for initially unresectable colorectal liver metastases.Am J Transl Res2020https://conductscience.org/library/papers/33042471PubMed
30,922,269First-line cetuximab versus bevacizumab for RAS and BRAF wild-type metastatic colorectal cancer: a systematic review and meta-analysis.BMC Cancer2019https://conductscience.org/library/papers/30922269PubMed
30,542,791Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (version 2018).J Cancer Res Clin Oncol2019https://conductscience.org/library/papers/30542791PubMed
30,323,980Multidisciplinary team intervention associated with improved survival for patients with colorectal adenocarcinoma with liver or lung metastasis.Am J Cancer Res2018https://conductscience.org/library/papers/30323980PubMed

1 to 10 of 57

See all 57 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MMP94,318PubTator's text mininghttps://conductscience.org/library/genes/4318NCBI Gene
VEGFA7,422PubTator's text mininghttps://conductscience.org/library/genes/7422NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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