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Paper · 20547751

Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.

Deisenroth C and 4 others. Mol Cell Biol, 2010. Cited by 55 papers, by iCite.

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ConductScience Library. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Papers, record 20547751. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20547751

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
PubMed
Journal
Mol Cell Biol
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
55
iCite
Relative citation ratio, by iCite
1.22
iCite
Revised in PubMed
2021-12-03
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Deisenroth CChad
2Thorner ARAaron R
3Enomoto TTakeharu
4Perou CMCharles M
5Zhang YYanping

Source PubMed

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Alcohol OxidoreductasesMajor topic
Genes, mybMajor topic
Nuclear ProteinsMajor topic
Proto-Oncogene Proteins c-mdm2Major topic
Tumor Suppressor Protein p53Major topic
Base Sequence
Breast Neoplasms
Carbonyl Reductase (NADPH)
Cell Line
Cell Line, Tumor
Cell Nucleus
Female
Humans
In Vitro Techniques
Microscopy, Immunoelectron
Mitochondria
Protein Binding
Protein Stability
Proto-Oncogene Mas
RNA Interference
RNA, Small Interfering
Receptors, Estrogen
Signal Transduction

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 ES010126NIEHS NIH HHSUnited StatesP30ES010126PubMed and NIHNIH RePORTER
R01 CA100302NCI NIH HHSUnited StatesR01CA100302PubMed and NIHNIH RePORTER
R01 CA127770NCI NIH HHSUnited StatesR01CA127770PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References63

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,331,603ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.Genes Dev2001https://conductscience.org/library/papers/11331603PubMed
210,322,429Mitochondrial-matrix proteins at unexpected locations: are they exported?Trends Biochem Sci1999https://conductscience.org/library/papers/10322429PubMed
312,972,026Myb protein specificity: evidence of a context-specific transcription factor code.Blood Cells Mol Dis2003https://conductscience.org/library/papers/12972026PubMed
415,314,174Inhibition of HDM2 and activation of p53 by ribosomal protein L23.Mol Cell Biol2004https://conductscience.org/library/papers/15314174PubMed
514,576,278The proteome of Saccharomyces cerevisiae mitochondria.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/14576278PubMed
619,204,204Supervised risk predictor of breast cancer based on intrinsic subtypes.J Clin Oncol2009https://conductscience.org/library/papers/19204204PubMed
79,344,880The tumor suppressor p53 is a negative regulator of estrogen receptor signaling pathways.Biochem Biophys Res Commun1997https://conductscience.org/library/papers/9344880PubMed
812,699,647Mechanisms of protein import into mitochondria.Curr Biol2003https://conductscience.org/library/papers/12699647PubMed
918,207,745Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.Curr Biol2008https://conductscience.org/library/papers/18207745PubMed
101,847,869Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells.Eur J Biochem1991https://conductscience.org/library/papers/1847869PubMed

1 to 10 of 63

See all 63 references

Cited by36

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 55 citations.

PMIDTitleJournalYearIn PapersSource
42,383,990Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes.FASEB J2026https://conductscience.org/library/papers/42383990PubMed
39,887,236Viral influencers: deciphering the role of endogenous retroviral LTR12 repeats in cellular gene expression.J Virol2025https://conductscience.org/library/papers/39887236PubMed
37,480,072N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope.Cell Commun Signal2023https://conductscience.org/library/papers/37480072PubMed
35,968,343Gentian violet induces apoptosis and ferroptosis via modulating p53 and MDM2 in hepatocellular carcinoma.Am J Cancer Res2022https://conductscience.org/library/papers/35968343PubMed
35,293,758Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.J Med Chem2022https://conductscience.org/library/papers/35293758PubMed
34,493,720Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.Nat Commun2021https://conductscience.org/library/papers/34493720PubMed
34,210,081Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D.Cells2021https://conductscience.org/library/papers/34210081PubMed
33,021,676HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression.Nucleic Acids Res2020https://conductscience.org/library/papers/33021676PubMed
32,586,085LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-CellsTurk J Haematol2020https://conductscience.org/library/papers/32586085PubMed
31,436,301Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.Oncol Rep2019https://conductscience.org/library/papers/31436301PubMed

1 to 10 of 36

See all 36 cited by

Genes8

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DHRS210,202Swiss-Prot's referenceshttps://conductscience.org/library/genes/10202NCBI Gene
ESR12,099PubTator's text mininghttps://conductscience.org/library/genes/2099NCBI Gene
MDM24,193PubTator's text mininghttps://conductscience.org/library/genes/4193NCBI Gene
MYB4,602PubTator's text mininghttps://conductscience.org/library/genes/4602NCBI Gene
RPL116,135PubTator's text mininghttps://conductscience.org/library/genes/6135NCBI Gene
RPL239,349PubTator's text mininghttps://conductscience.org/library/genes/9349NCBI Gene
RPL56,125PubTator's text mininghttps://conductscience.org/library/genes/6125NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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