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Paper · 20688981

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Boitano AE and 11 others. Science, 2010. Cited by 862 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Papers, record 20688981. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20688981

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.
PubMed
Journal
Science
PubMed
Year
2010
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
862
iCite
Relative citation ratio, by iCite
18.5
iCite
Revised in PubMed
2025-05-29
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Boitano AEAnthony E
2Wang JJian
3Romeo RRussell
4Bouchez LCLaure C
5Parker AEAlbert E
6Sutton SESue E
7Walker JRJohn R
8Flaveny CAColin A
9Perdew GHGary H
10Denison MSMichael S

1 to 10 of 12Source PubMed

See all 12 authors

Topics27

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Hematopoietic Stem Cell TransplantationMajor topic
Hematopoietic Stem CellsMajor topic
PurinesMajor topic
Receptors, Aryl HydrocarbonMajor topic
AC133 Antigen
Animals
Antigens, CD
Antigens, CD34
Aryl Hydrocarbon Hydroxylases
Cell Count
Cell Lineage
Cell Proliferation
Cells, Cultured
Cytochrome P-450 CYP1B1
Cytokines
Glycoproteins
Hematopoiesis
Humans
Mice
Mice, Inbred NOD
Mice, SCID
Multipotent Stem Cells
Peptides
Polychlorinated Dibenzodioxins
Signal Transduction
Small Molecule Libraries
Species Specificity

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 ES007685NIEHS NIH HHSUnited StatesR01ES007685PubMed and NIHNIH RePORTER
ES007685NIEHS NIH HHSUnited StatesR01ES007685PubMed and NIHNIH RePORTER
P42 ES004699NIEHS NIH HHSUnited StatesP42ES004699PubMed and NIHNIH RePORTER
ES04699NIEHS NIH HHSUnited StatesP42ES004699PubMed and NIHNIH RePORTER
ES004869NIEHS NIH HHSUnited StatesR01ES004869PubMed and NIHNIH RePORTER
R01 ES004869NIEHS NIH HHSUnited StatesR01ES004869PubMed and NIHNIH RePORTER
R29ES004869NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in20,829,472Medicine. The blood stem cell Holy Grail?https://conductscience.org/library/papers/20829472

Source PubMed

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,536,565Phenotypic and functional characterization of hematopoietic stem cells.Curr Opin Hematol2008https://conductscience.org/library/papers/18536565PubMed
28,812,265Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.Fundam Appl Toxicol1996https://conductscience.org/library/papers/8812265PubMed
319,299,563Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice.Mol Pharmacol2009https://conductscience.org/library/papers/19299563PubMed
417,581,586Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.Nature2007https://conductscience.org/library/papers/17581586PubMed
512,615,892Biology of hematopoietic stem cells and progenitors: implications for clinical application.Annu Rev Immunol2003https://conductscience.org/library/papers/12615892PubMed
617,359,369Expanding the role of umbilical cord blood transplantation.Br J Haematol2007https://conductscience.org/library/papers/17359369PubMed
711,853,431A combinatorial scaffold approach toward kinase-directed heterocycle libraries.J Am Chem Soc2002https://conductscience.org/library/papers/11853431PubMed
818,820,284Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells.Carcinogenesis2009https://conductscience.org/library/papers/18820284PubMed
917,889,503Antiteratogenic effects of alpha-naphthoflavone on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed mice in utero.Reprod Toxicol2007https://conductscience.org/library/papers/17889503PubMed
1012,604,837TCDD treatment eliminates the long-term reconstitution activity of hematopoietic stem cells.Toxicol Sci2003https://conductscience.org/library/papers/12604837PubMed

1 to 10 of 24

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Cited by582

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 862 citations.

PMIDTitleJournalYearIn PapersSource
42,828,480Engineering IL-4 resistant proinflammatory human myeloid cells for cancer immunotherapy.Mol Oncol2026https://conductscience.org/library/papers/42828480PubMed
42,797,726aip Mutant Zebrafish Display Morphological and Transcriptional Changes Associated with Stress-Induced Hematopoiesis.Toxics2026https://conductscience.org/library/papers/42797726PubMed
42,794,798Mechanistic Insights into Regulation of the Aryl Hydrocarbon Receptor Expression in Mouse and Human Hepatoma Cells.Int J Mol Sci2026https://conductscience.org/library/papers/42794798PubMed
42,634,082The making of cells and organs in xenogeneic animal bioreactor.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42634082PubMed
42,486,681JARID2 inhibition reprograms human hematopoietic progenitor cells to enhance bone marrow transplantation.Blood Adv2026https://conductscience.org/library/papers/42486681PubMed
42,394,187Releasing the neuronal brake: Inhibiting AhR to enhance axon regeneration.Clin Transl Med2026https://conductscience.org/library/papers/42394187PubMed
42,387,854Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells.Stem Cells Transl Med2026https://conductscience.org/library/papers/42387854PubMed
42,385,421Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential.Pharmacol Rev2026https://conductscience.org/library/papers/42385421PubMed
42,239,194Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies.bioRxiv2026https://conductscience.org/library/papers/42239194PubMed
42,198,848Ex vivo expansion of hematopoietic stem and progenitor cells from human mobilized peripheral blood for gene therapy applications.Mol Ther2026https://conductscience.org/library/papers/42198848PubMed

1 to 10 of 582

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AHR196PubTator's text mininghttps://conductscience.org/library/genes/196NCBI Gene
AHRR57,491PubTator's text mininghttps://conductscience.org/library/genes/57491NCBI Gene
CD19930PubTator's text mininghttps://conductscience.org/library/genes/930NCBI Gene
CD33945PubTator's text mininghttps://conductscience.org/library/genes/945NCBI Gene
CD34947PubTator's text mininghttps://conductscience.org/library/genes/947NCBI Gene
CYP1B11,545PubTator's text mininghttps://conductscience.org/library/genes/1545NCBI Gene
DPP41,803PubTator's text mininghttps://conductscience.org/library/genes/1803NCBI Gene
FLT3LG2,323PubTator's text mininghttps://conductscience.org/library/genes/2323NCBI Gene
GSK3B2,932PubTator's text mininghttps://conductscience.org/library/genes/2932NCBI Gene
IL63,569PubTator's text mininghttps://conductscience.org/library/genes/3569NCBI Gene

1 to 10 of 16

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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