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Paper · 2139098

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

Gao EK and 2 others. J Exp Med, 1990. Cited by 127 papers, by iCite.

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ConductScience Library. Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy. Papers, record 2139098. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2139098

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.
PubMed
Journal
J Exp Med
PubMed
Year
1990
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
127
iCite
Relative citation ratio, by iCite
1.92
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Gao EKE K
2Lo DD
3Sprent JJ

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Bone MarrowMajor topic
Immune ToleranceMajor topic
Skin TransplantationMajor topic
T-LymphocytesMajor topic
Animals
Antibodies, Monoclonal
CD4 Antigens
Cesium Radioisotopes
Chimera
Cortisone
Flow Cytometry
Fluorescent Antibody Technique
Gamma Rays
Graft vs Host Disease
H-2 Antigens
Lymphocyte Culture Test, Mixed
Mice
Mice, Inbred Strains

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI-21487NIAID NIH HHSUnited StatesR01AI021487PubMed and NIHNIH RePORTER
CA-25803NCI NIH HHSUnited StatesP01CA025803PubMed and NIHNIH RePORTER
CA-38355NCI NIH HHSUnited StatesR01CA038355PubMed and NIHNIH RePORTER
R37CA038355NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References39

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
146,268Tolerance to histocompatibility determinants in tetraparental bone marrow chimeras.J Exp Med1975https://conductscience.org/library/papers/46268PubMed
26,195,085
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.
Immunol Rev1983https://conductscience.org/library/papers/6195085PubMed
358,461T cell function in bone marrow chimeras: absence of host-reactive T cells and cooperation of helper T cells across allogeneic barriers.Transplant Rev1976https://conductscience.org/library/papers/58461PubMed
4304,527Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.Nature1978https://conductscience.org/library/papers/304527PubMed
5567,555Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.Curr Top Microbiol Immunol1978https://conductscience.org/library/papers/567555PubMed
6308,986H-2 antigens of the thymus determine lymphocyte specificity.J Exp Med1978https://conductscience.org/library/papers/308986PubMed
77,188,699Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.J Immunol1980https://conductscience.org/library/papers/7188699PubMed
86,159,417IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.J Immunol1980https://conductscience.org/library/papers/6159417PubMed
96,935,293Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.J Immunol1981https://conductscience.org/library/papers/6935293PubMed
106,940,949Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice.J Exp Med1981https://conductscience.org/library/papers/6940949PubMed

1 to 10 of 39

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Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 127 citations.

PMIDTitleJournalYearIn PapersSource
35,069,574Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives.Front Immunol2021https://conductscience.org/library/papers/35069574PubMed
34,711,828Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules.Nat Commun2021https://conductscience.org/library/papers/34711828PubMed
30,557,341Cell-intrinsic regulation of peripheral memory-phenotype T cell frequencies.PLoS One2018https://conductscience.org/library/papers/30557341PubMed
28,947,612Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches.J Exp Med2017https://conductscience.org/library/papers/28947612PubMed
20,555,306The role of the thymus in tolerance.Transplantation2010https://conductscience.org/library/papers/20555306PubMed
20,452,826Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen.Clin Immunol2010https://conductscience.org/library/papers/20452826PubMed
19,073,916Dendritic cells in the thymus contribute to T-regulatory cell induction.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/19073916PubMed
15,492,126Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation.J Exp Med2004https://conductscience.org/library/papers/15492126PubMed
12,519,299In vivo maintenance of T-lymphocyte unresponsiveness induced by thymic medullary epithelium requires antigen presentation by radioresistant cells.Immunology2003https://conductscience.org/library/papers/12519299PubMed
11,034,604
Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation.
J Exp Med2000https://conductscience.org/library/papers/11034604PubMed

1 to 10 of 30

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
IL23,558PubTator's text mininghttps://conductscience.org/library/genes/3558NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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