ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 308986

H-2 antigens of the thymus determine lymphocyte specificity.

Fink PJ and 1 other. J Exp Med, 1978. Cited by 327 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. H-2 antigens of the thymus determine lymphocyte specificity. Papers, record 308986. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/308986

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
H-2 antigens of the thymus determine lymphocyte specificity.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
327
iCite
Relative citation ratio, by iCite
4.83
iCite
Revised in PubMed
2021-12-03
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Fink PJP J
2Bevan MJM J

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
H-2 AntigensMajor topic
T-LymphocytesMajor topic
Thymus GlandMajor topic
Animals
Cell Differentiation
Cytotoxicity, Immunologic
Immunization, Passive
Immunosuppression Therapy
Lymph Nodes
Mice
Spleen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,073,428Determinant selection is a macrophage dependent immune response gene function.Nature1977https://conductscience.org/library/papers/16073428PubMed
214,071,261THYMECTOMY IN NEWBORN AND ADULT MICE.Transplantation1963https://conductscience.org/library/papers/14071261PubMed
395,787Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.J Exp Med1977https://conductscience.org/library/papers/95787PubMed
462,016H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.J Exp Med1976https://conductscience.org/library/papers/62016PubMed
568,474Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/68474PubMed
6320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed
7304,527Cytotoxic T cells learn specificity for self H-2 during differentiation in the thymus.Nature1978https://conductscience.org/library/papers/304527PubMed
8305,460The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.J Exp Med1978https://conductscience.org/library/papers/305460PubMed
9305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed
10306,404T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.J Exp Med1978https://conductscience.org/library/papers/306404PubMed

1 to 10 of 24

See all 24 references

Cited by101

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 327 citations.

PMIDTitleJournalYearIn PapersSource
40,936,899Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens.Front Immunol2025https://conductscience.org/library/papers/40936899PubMed
40,067,587Thymic Crosstalk: An Overview of the Complex Cellular Interactions that Control the Establishment of T-Cell Tolerance.Adv Exp Med Biol2025https://conductscience.org/library/papers/40067587PubMed
37,464,188A guide to thymic selection of T cells.Nat Rev Immunol2024https://conductscience.org/library/papers/37464188PubMed
30,120,895Human cancer evolution in the context of a human immune system in mice.Mol Oncol2018https://conductscience.org/library/papers/30120895PubMed
29,148,973The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.Elife2017https://conductscience.org/library/papers/29148973PubMed
28,450,862Differential Response of Mouse Thymic Epithelial Cell Types to Ionizing Radiation-Induced DNA Damage.Front Immunol2017https://conductscience.org/library/papers/28450862PubMed
27,641,500Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.Cell2016https://conductscience.org/library/papers/27641500PubMed
27,588,903Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.Proc Natl Acad Sci U S A2016https://conductscience.org/library/papers/27588903PubMed
24,363,430A methods paper that led to much more.J Immunol2014https://conductscience.org/library/papers/24363430PubMed
23,046,122T cells and their eons-old obsession with MHC.Immunol Rev2012https://conductscience.org/library/papers/23046122PubMed

1 to 10 of 101

See all 101 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/308986

GET https://conductscience.org/api/papers/v1/308986/references?page=2

API referenceFor AI assistants