ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 306404

T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

Janeway CA and 3 others. J Exp Med, 1978. Cited by 48 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten. Papers, record 306404. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/306404

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
48
iCite
Relative citation ratio, by iCite
1.08
iCite
Revised in PubMed
2019-05-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Janeway CA JrC A
2Murphy PDP D
3Kemp JJ
4Wigzell HH

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
H-2 AntigensMajor topic
HaptensMajor topic
T-LymphocytesMajor topic
Animals
Bromodeoxyuridine
Cell Survival
Cytotoxicity, Immunologic
Heterozygote
Immunity, Cellular
Immunologic Memory
Killer Cells, Natural
Light
Mice
Trinitrobenzenes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References19

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
163,531The specificity of cellular immune responses in guinea pigs. III. The precision of antigen recognition by T lymphocytes.J Exp Med1976https://conductscience.org/library/papers/63531PubMed
262,013Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.J Exp Med1976https://conductscience.org/library/papers/62013PubMed
363,988Two different VH gene products make up the T-cell receptors.Scand J Immunol1976https://conductscience.org/library/papers/63988PubMed
468,474Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/68474PubMed
5141,046Killer cells reactive to altered-self antigens can also be alloreactive.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/141046PubMed
6135,687Micromethods for induction and assay of mouse mixed lymphocyte reactions and cytotoxicity.Eur J Immunol1976https://conductscience.org/library/papers/135687PubMed
7417,392Cell-mediated immunity and the major histocompatibility complex.Rev Physiol Biochem Pharmacol1978https://conductscience.org/library/papers/417392PubMed
8320,663Functional specificity of thymus- dependent lymphocytes.Science1977https://conductscience.org/library/papers/320663PubMed
9305,460The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.J Exp Med1978https://conductscience.org/library/papers/305460PubMed
10305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed

1 to 10 of 19

See all 19 references

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 48 citations.

PMIDTitleJournalYearIn PapersSource
22,567,140A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity.PLoS One2012https://conductscience.org/library/papers/22567140PubMed
22,457,921T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.Immunogenetics1980https://conductscience.org/library/papers/22457921PubMed
6,980,965Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.J Exp Med1982https://conductscience.org/library/papers/6980965PubMed
6,978,924Low dose radiosensitivity of alloimmune cytotoxic T cells.J Exp Med1982https://conductscience.org/library/papers/6978924PubMed
6,973,002H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.J Exp Med1981https://conductscience.org/library/papers/6973002PubMed
6,965,308Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.J Exp Med1980https://conductscience.org/library/papers/6965308PubMed
6,792,318Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.J Exp Med1981https://conductscience.org/library/papers/6792318PubMed
6,455,762T cell recognition of antigen in vivo: role of the H-2 complex.Springer Semin Immunopathol1980https://conductscience.org/library/papers/6455762PubMed
6,261,255
H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.
Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6261255PubMed
6,132,381Clones of cytotoxic T lymphocytes reactive to haptenated allogeneic cells: precursor frequency and characteristics as determined by a split-culture approach.Proc Natl Acad Sci U S A1983https://conductscience.org/library/papers/6132381PubMed

1 to 10 of 13

See all 13 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/306404

GET https://conductscience.org/api/papers/v1/306404/authors

API referenceFor AI assistants