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Paper · 22522926

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.

Jonker JW and 14 others. Nature, 2012. Cited by 246 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Papers, record 22522926. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/22522926

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
PubMed
Journal
Nature
PubMed
Year
2012
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
246
iCite
Relative citation ratio, by iCite
6.45
iCite
Revised in PubMed
2025-05-29
PubMed

Authors15

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Jonker JWJohan W
2Suh JMJae Myoung
3Atkins ARAnnette R
4Ahmadian MMaryam
5Li PPingping
6Whyte JJamie
7He MMingxiao
8Juguilon HHenry
9Yin YQYun-Qiang
10Phillips CTColin T

1 to 10 of 15Source PubMed

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Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fibroblast Growth Factor 1Major topic
HomeostasisMajor topic
Intra-Abdominal FatMajor topic
PPAR gammaMajor topic
Adipocytes
Animals
Base Sequence
Cell Size
Diabetes Mellitus, Experimental
Diet, High-Fat
Humans
Inflammation
Insulin
Insulin Resistance
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Necrosis
Promoter Regions, Genetic
Response Elements

Source PubMed

Grants18

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 HL105278NHLBI NIH HHSUnited StatesR01HL105278PubMed and NIHNIH RePORTER
DK062434NIDDK NIH HHSUnited StatesU19DK062434PubMed and NIHNIH RePORTER
U19 DK062434NIDDK NIH HHSUnited StatesU19DK062434PubMed and NIHNIH RePORTER
P30 DK063491NIDDK NIH HHSUnited StatesP30DK063491PubMed and NIHNIH RePORTER
Howard Hughes Medical InstituteUnited StatesPubMedPubMed
R37 DK057978NIDDK NIH HHSUnited StatesR01DK057978PubMed and NIHNIH RePORTER
DK063491NIDDK NIH HHSUnited StatesP30DK063491PubMed and NIHNIH RePORTER
HL105278NHLBI NIH HHSUnited StatesR01HL105278PubMed and NIHNIH RePORTER
P50 HD012303NICHD NIH HHSUnited StatesP50HD012303PubMed and NIHNIH RePORTER
R37 DK033651NIDDK NIH HHSUnited StatesR01DK033651PubMed and NIHNIH RePORTER

1 to 10 of 18

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References31

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
120,667,984Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.Mol Endocrinol2010https://conductscience.org/library/papers/20667984PubMed
214,660,788Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/14660788PubMed
321,633,177Adipose tissue remodeling and obesity.J Clin Invest2011https://conductscience.org/library/papers/21633177PubMed
414,625,542Muscle-specific Pparg deletion causes insulin resistance.Nat Med2003https://conductscience.org/library/papers/14625542PubMed
521,300,871Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance.Proc Natl Acad Sci U S A2011https://conductscience.org/library/papers/21300871PubMed
610,933,915Angiogenesis monitored by perfusion with a space-filling microbead suspension.Mol Ther2000https://conductscience.org/library/papers/10933915PubMed
718,518,822Fat and beyond: the diverse biology of PPARgamma.Annu Rev Biochem2008https://conductscience.org/library/papers/18518822PubMed
818,058,912Functional evolutionary history of the mouse Fgf gene family.Dev Dyn2008https://conductscience.org/library/papers/18058912PubMed
910,688,672Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.Mol Cell Biol2000https://conductscience.org/library/papers/10688672PubMed
10569,296[Studies of lipase-induced fat necrosis in rats (author's transl)].Pathol Res Pract1978https://conductscience.org/library/papers/569296PubMed

1 to 10 of 31

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Cited by170

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 246 citations.

PMIDTitleJournalYearIn PapersSource
42,633,326Advances in FGF/FGFR Signaling: Implications for Disease and Therapy.MedComm (2020)2026https://conductscience.org/library/papers/42633326PubMed
42,511,911The Role of FGF1 in Chronic Liver Diseases.Biomedicines2026https://conductscience.org/library/papers/42511911PubMed
42,443,887Gender-wise distribution of metabolic risk factors and their relationship with fibroblast growth factor 1 and gene polymorphism (rs152524).BMC Med Genomics2026https://conductscience.org/library/papers/42443887PubMed
42,319,926Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1.Sci Adv2026https://conductscience.org/library/papers/42319926PubMed
42,310,100Adipocyte-specific ablation of Gadd45b exacerbates obesity-associated cellular senescence and metabolic disorders via Fgf1b promoter hypermethylation.Cell Death Differ2026https://conductscience.org/library/papers/42310100PubMed
41,857,047FGF1 orchestrates circadian hepatic triglyceride secretion.Nat Commun2026https://conductscience.org/library/papers/41857047PubMed
41,828,344Fgf10 Gene Dosage from a Single Allele Is Insufficient for Forming Multilayered Epithelial Cells in the Murine Lacrimal Gland.Int J Mol Sci2026https://conductscience.org/library/papers/41828344PubMed
41,827,821Human FGF1ΔHBS Gene Therapy as Treatment for Metabolic Dysfunction-Associated Steatohepatitis in ApoE-KO Mice.Cells2026https://conductscience.org/library/papers/41827821PubMed
41,696,093Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney.World J Diabetes2026https://conductscience.org/library/papers/41696093PubMed
41,624,951Acute β-cell failure induced by selpercatinib in RET fusion-positive non-small cell lung cancer: A case report.Respir Med Case Rep2026https://conductscience.org/library/papers/41624951PubMed

1 to 10 of 170

See all 170 cited by

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
FGF12,246PubTator's text mininghttps://conductscience.org/library/genes/2246NCBI Gene
PPARA5,465PubTator's text mininghttps://conductscience.org/library/genes/5465NCBI Gene
PPARD5,467PubTator's text mininghttps://conductscience.org/library/genes/5467NCBI Gene
PPARG5,468PubTator's text mininghttps://conductscience.org/library/genes/5468NCBI Gene
SSX2IP117,178PubTator's text mininghttps://conductscience.org/library/genes/117178NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE31692

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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