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Paper · 23770567

Mutational heterogeneity in cancer and the search for new cancer-associated genes.

Lawrence MS and 63 others. Nature, 2013. Cited by 4,267 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Papers, record 23770567. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/23770567

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Mutational heterogeneity in cancer and the search for new cancer-associated genes.
PubMed
Journal
Nature
PubMed
Year
2013
PubMed
Publication types
Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
4,267
iCite
Relative citation ratio, by iCite
114
iCite
Revised in PubMed
2025-05-29
PubMed

Authors64

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lawrence MSMichael S
2Stojanov PPetar
3Polak PPaz
4Kryukov GVGregory V
5Cibulskis KKristian
6Sivachenko AAndrey
7Carter SLScott L
8Stewart CChip
9Mermel CHCraig H
10Roberts SASteven A

1 to 10 of 64Source PubMed

See all 64 authors

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Genetic HeterogeneityMajor topic
MutationMajor topic
NeoplasmsMajor topic
OncogenesMajor topic
Artifacts
DNA Replication Timing
Exome
False Positive Reactions
Gene Expression
Genome, Human
Humans
Lung Neoplasms
Mutation Rate
Neoplasms, Squamous Cell
Reproducibility of Results
Sample Size

Source PubMed

Grants8

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
U54 HG003067NHGRI NIH HHSUnited StatesU54HG003067PubMed and NIHNIH RePORTER
Z01 ES065073Intramural NIH HHSUnited StatesZ01ES065073PubMed and NIHNIH RePORTER
Howard Hughes Medical InstituteUnited StatesPubMedPubMed
U24 CA143845NCI NIH HHSUnited StatesU24CA143845PubMed and NIHNIH RePORTER
T32 GM007753NIGMS NIH HHSUnited StatesT32GM007753PubMed and NIHNIH RePORTER
T32 CA009172NCI NIH HHSUnited StatesT32CA009172PubMed and NIHNIH RePORTER
T32 CA009216NCI NIH HHSUnited StatesT32CA009216PubMed and NIHNIH RePORTER
ZIAES065073NIHNIH RePORTER

Trials3

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT02963090Pembrolizumab vs Topotecan in Patients With Small Cell Lung CancerBackgroundClinicalTrials.gov
NCT03824691hARnessing CAbozantinib and Durvalumab Immuno-oncology Association: ARCADIA Study"ResultsClinicalTrials.gov
NCT06680791Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle FactorsBackgroundClinicalTrials.gov

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in24,104,755Differences that matter in cancer genomics.https://conductscience.org/library/papers/24104755

Source PubMed

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,722,201The landscape of cancer genes and mutational processes in breast cancer.Nature2012https://conductscience.org/library/papers/22722201PubMed
217,344,846Patterns of somatic mutation in human cancer genomes.Nature2007https://conductscience.org/library/papers/17344846PubMed
322,622,578Melanoma genome sequencing reveals frequent PREX2 mutations.Nature2012https://conductscience.org/library/papers/22622578PubMed
422,536,466Meta-analysis of studies analyzing the role of human papillomavirus in the development of bladder carcinoma.Korean J Urol2012https://conductscience.org/library/papers/22536466PubMed
520,016,488A small-cell lung cancer genome with complex signatures of tobacco exposure.Nature2010https://conductscience.org/library/papers/20016488PubMed
621,969,038Variation in the mutation rate across mammalian genomes.Nat Rev Genet2011https://conductscience.org/library/papers/21969038PubMed
721,430,775Initial genome sequencing and analysis of multiple myeloma.Nature2011https://conductscience.org/library/papers/21430775PubMed
818,757,741Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.Proc Natl Acad Sci U S A2008https://conductscience.org/library/papers/18757741PubMed
923,176,822Differential relationship of DNA replication timing to different forms of human mutation and variation.Am J Hum Genet2012https://conductscience.org/library/papers/23176822PubMed
1018,772,890Comprehensive genomic characterization defines human glioblastoma genes and core pathways.Nature2008https://conductscience.org/library/papers/18772890PubMed

1 to 10 of 30

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Cited by3,268

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 4,267 citations.

PMIDTitleJournalYearIn PapersSource
42,989,294MAP of molecular analyses in real-worlD oncology centers - MAPpaMoNDO: a study of the translational research Young GOIM group.J Transl Med2026https://conductscience.org/library/papers/42989294PubMed
42,989,104MutFormer: a multimodal deep learning framework for predicting somatic mutation hotspots from sequence and chromatin features.BMC Genomics2026https://conductscience.org/library/papers/42989104PubMed
42,972,343Promises and pitfalls of mRNA-based vaccines as cancer treatment.BMC Biol2026https://conductscience.org/library/papers/42972343PubMed
42,962,034Evidence of active whole-genome doubling (WGD) subclones in non-WGD tumors.Sci Adv2026https://conductscience.org/library/papers/42962034PubMed
42,944,785Exploratory whole-genome sequencing of cagA-positive Helicobacter pylori-associated gastric biopsies: descriptive observations in COL3A1, ICAM1, and COLEC12.Mol Biol Rep2026https://conductscience.org/library/papers/42944785PubMed
42,919,392Unraveling the use of vaccine therapy in HER2-positive breast cancer: a comprehensive review of current state and future perspectives.J Exp Clin Cancer Res2026https://conductscience.org/library/papers/42919392PubMed
42,909,927UPF1-mediated mRNA decay promotes melanoma tumorigenesis through miR-101-3p-dependent destabilization of NANOS1.Int J Biol Sci2026https://conductscience.org/library/papers/42909927PubMed
42,883,885Genome-Wide Characterisation of Somatic Mutations Across COSMIC Cancer Cell Lines Enables Gene-Centric Experimental Model Selection.Int J Mol Sci2026https://conductscience.org/library/papers/42883885PubMed
42,879,031A Practical Compass to Biological Digital Resources and Omics Integration in Ewing Sarcoma.Methods Mol Biol2027https://conductscience.org/library/papers/42879031PubMed
42,864,811A Living Multi-Omics PDX Biobank of High-Risk Sarcomas Reveals ecDNA-Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42864811PubMed

1 to 10 of 3,268

See all 3,268 cited by

Genes35

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCDC68,030PubTator's text mininghttps://conductscience.org/library/genes/8030NCBI Gene
CCL216,366PubTator's text mininghttps://conductscience.org/library/genes/6366NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
CHM1,121PubTator's text mininghttps://conductscience.org/library/genes/1121NCBI Gene
CNTN553,942PubTator's text mininghttps://conductscience.org/library/genes/53942NCBI Gene
CNTNAP226,047PubTator's text mininghttps://conductscience.org/library/genes/26047NCBI Gene
CNTNAP485,445PubTator's text mininghttps://conductscience.org/library/genes/85445NCBI Gene
CNTNAP5129,684PubTator's text mininghttps://conductscience.org/library/genes/129684NCBI Gene
CSMD164,478PubTator's text mininghttps://conductscience.org/library/genes/64478NCBI Gene
CSMD3114,788PubTator's text mininghttps://conductscience.org/library/genes/114788NCBI Gene

1 to 10 of 35

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Drugs2

The drugs whose trials, in the Pipelines release, list the paper.

DrugChEMBL IDThe trials list it asTrialsIn Drugs and targetsSource
CABOZANTINIBCHEMBL2105717Results1https://conductscience.org/library/drugs/CHEMBL2105717ChEMBL
DURVALUMABCHEMBL3301587Results1https://conductscience.org/library/drugs/CHEMBL3301587ChEMBL

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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