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Paper · 26865249

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment.

Rupaimoole R and 3 others. Cancer Discov, 2016. Cited by 541 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. miRNA Deregulation in Cancer Cells and the Tumor Microenvironment. Papers, record 26865249. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26865249

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment.
PubMed
Journal
Cancer Discov
PubMed
Year
2016
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review
PubMed
Citations, by iCite
541
iCite
Relative citation ratio, by iCite
19.2
iCite
Revised in PubMed
2022-04-08
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Rupaimoole RRajesha
2Calin GAGeorge A
3Lopez-Berestein GGabriel
4Sood AKAnil K

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene Expression Regulation, NeoplasticMajor topic
MicroRNAsMajor topic
NeoplasmsMajor topic
Tumor MicroenvironmentMajor topic
Animals
Cell Transformation, Neoplastic
Disease Progression
Fibroblasts
Gene Regulatory Networks
Humans
Hypoxia
Inflammation
Signal Transduction

Source PubMed

Grants17

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
UH3TR000943NCATS NIH HHSUnited StatesUH3TR000943PubMed and NIHNIH RePORTER
CA109298NCI NIH HHSUnited StatesR01CA109298PubMed and NIHNIH RePORTER
P30 CA016672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
U24 CA143835NCI NIH HHSUnited StatesU24CA143835PubMed and NIHNIH RePORTER
P50 CA097007NCI NIH HHSUnited StatesP50CA097007PubMed and NIHNIH RePORTER
CA182905NCI NIH HHSUnited StatesR01CA182905PubMed and NIHNIH RePORTER
P50 CA100632NCI NIH HHSUnited StatesP50CA100632PubMed and NIHNIH RePORTER
R01 CA177909NCI NIH HHSUnited StatesR01CA177909PubMed and NIHNIH RePORTER
UH3 TR000943NCATS NIH HHSUnited StatesUH3TR000943PubMed and NIHNIH RePORTER
R01 CA109298NCI NIH HHSUnited StatesR01CA109298PubMed and NIHNIH RePORTER

1 to 10 of 17

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References99

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
123,550,646MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer.Immunol Rev2013https://conductscience.org/library/papers/23550646PubMed
224,011,070The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation.Cell Metab2013https://conductscience.org/library/papers/24011070PubMed
321,690,566MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma.Cancer Res2011https://conductscience.org/library/papers/21690566PubMed
425,351,346Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.Nat Commun2014https://conductscience.org/library/papers/25351346PubMed
524,581,491Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.Cell2014https://conductscience.org/library/papers/24581491PubMed
621,627,858MicroRNA therapeutics: principles, expectations, and challenges.Chin J Cancer2011https://conductscience.org/library/papers/21627858PubMed
716,885,212NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.Proc Natl Acad Sci U S A2006https://conductscience.org/library/papers/16885212PubMed
819,092,150Dicer, Drosha, and outcomes in patients with ovarian cancer.N Engl J Med2008https://conductscience.org/library/papers/19092150PubMed
917,440,684Hypoxia in cancer: significance and impact on clinical outcome.Cancer Metastasis Rev2007https://conductscience.org/library/papers/17440684PubMed
1021,383,199Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer.Proc Natl Acad Sci U S A2011https://conductscience.org/library/papers/21383199PubMed

1 to 10 of 99

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Cited by399

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 541 citations.

PMIDTitleJournalYearIn PapersSource
42,501,212Nanotechnology-enabled precision targeting of lung cancer stem cells: Recent developments and therapeutic implications.Stem Cell Rev Rep2026https://conductscience.org/library/papers/42501212PubMed
42,346,070MiR-23c Regulates the Resistance to Gefitinib in EGFR Mutant Non-Small-Cell Lung Cancer Cells.Cells2026https://conductscience.org/library/papers/42346070PubMed
42,192,969miRNA-lncRNA Cross-Regulation Landscape in Cancer: From Molecular Mechanisms to Therapeutic and Diagnostic Applications.Cancers (Basel)2026https://conductscience.org/library/papers/42192969PubMed
41,949,997A tumor suppressor role of the miR-15b/16-2 cluster in T-cell acute lymphoblastic leukemia.Blood2026https://conductscience.org/library/papers/41949997PubMed
41,888,092HIF-1α suppresses SNPH expression to facilitate liver metastasis of colorectal cancer through regulating mitochondrial dynamics and filopodia formation.Cell Death Dis2026https://conductscience.org/library/papers/41888092PubMed
41,629,079[Expert consensus on the diagnosis, treatment, and management of liver nodules (version 2026)].Zhonghua Gan Zang Bing Za Zhi2026https://conductscience.org/library/papers/41629079PubMed
41,604,020The role of microRNAs in modulating Wnt signaling pathway dynamics and their therapeutic implications in non-small cell lung cancer.Discov Oncol2026https://conductscience.org/library/papers/41604020PubMed
41,543,151Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review).Oncol Rep2026https://conductscience.org/library/papers/41543151PubMed
41,523,763Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns.World J Exp Med2025https://conductscience.org/library/papers/41523763PubMed
41,511,728MiR-31 suppresses lung adenocarcinoma cell proliferation through CDK1 and E2F2-mediated cell cycle arrest.Discov Oncol2026https://conductscience.org/library/papers/41511728PubMed

1 to 10 of 399

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Genes37

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ADARB1104PubTator's text mininghttps://conductscience.org/library/genes/104NCBI Gene
AGO227,161PubTator's text mininghttps://conductscience.org/library/genes/27161NCBI Gene
CCN21,490PubTator's text mininghttps://conductscience.org/library/genes/1490NCBI Gene
DGCR854,487PubTator's text mininghttps://conductscience.org/library/genes/54487NCBI Gene
DICER123,405PubTator's text mininghttps://conductscience.org/library/genes/23405NCBI Gene
DROSHA29,102PubTator's text mininghttps://conductscience.org/library/genes/29102NCBI Gene
E2F11,869PubTator's text mininghttps://conductscience.org/library/genes/1869NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
ELK12,002PubTator's text mininghttps://conductscience.org/library/genes/2002NCBI Gene
EPAS12,034PubTator's text mininghttps://conductscience.org/library/genes/2034NCBI Gene

1 to 10 of 37

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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