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Paper · 27731925

G-protein-coupled receptor signaling and neural tube closure defects.

Shimada IS and 1 other. Birth Defects Res, 2017. Cited by 13 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. G-protein-coupled receptor signaling and neural tube closure defects. Papers, record 27731925. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/27731925

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
G-protein-coupled receptor signaling and neural tube closure defects.
PubMed
Journal
Birth Defects Res
PubMed
Year
2017
PubMed
Publication types
Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
13
iCite
Relative citation ratio, by iCite
0.46
iCite
Revised in PubMed
2018-11-13
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Shimada ISIssei S
2Mukhopadhyay SSaikathttps://orcid.org/0000-0003-4790-3090

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Hedgehog ProteinsMajor topic
Neural TubeMajor topic
Neural Tube DefectsMajor topic
NeurulationMajor topic
Receptors, G-Protein-CoupledMajor topic
Signal TransductionMajor topic
Animals
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Embryonic Development
Gene Expression Regulation, Developmental
High-Throughput Nucleotide Sequencing
Humans
Mutation
Organogenesis

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 GM113023NIGMS NIH HHSUnited StatesR01GM113023PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References127

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,819,326Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes.DNA Res2000https://conductscience.org/library/papers/10819326PubMed
210,693,759Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.Cell2000https://conductscience.org/library/papers/10693759PubMed
316,267,828Phosphodiesterase-Ialpha/autotaxin (PD-Ialpha/ATX): a multifunctional protein involved in central nervous system development and disease.J Neurosci Res2005https://conductscience.org/library/papers/16267828PubMed
422,632,972Planar cell polarity links axes of spatial dynamics in neural-tube closure.Cell2012https://conductscience.org/library/papers/22632972PubMed
59,087,410Protease-activated receptor 3 is a second thrombin receptor in humans.Nature1997https://conductscience.org/library/papers/9087410PubMed
619,161,225Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system.Dev Dyn2009https://conductscience.org/library/papers/19161225PubMed
73,619,087Cell cycle and neuroepithelial cell shape during bending of the chick neural plate.Anat Rec1987https://conductscience.org/library/papers/3619087PubMed
820,016,067Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base.J Cell Sci2010https://conductscience.org/library/papers/20016067PubMed
925,753,732The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation.Dev Biol2015https://conductscience.org/library/papers/25753732PubMed
1017,912,034Morphogens and the control of cell proliferation and patterning in the spinal cord.Cell Cycle2007https://conductscience.org/library/papers/17912034PubMed

1 to 10 of 127

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Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 13 citations.

PMIDTitleJournalYearIn PapersSource
42,269,381International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacol Rev2026https://conductscience.org/library/papers/42269381PubMed
40,973,161Genomic study for pregnancy loss in Brahman cattle.J Anim Sci2025https://conductscience.org/library/papers/40973161PubMed
38,544,816Multiplexing of TMT labeling reveals folate-deficient diet-specific proteome changes in NTDs.Front Cell Dev Biol2024https://conductscience.org/library/papers/38544816PubMed
38,285,286Inpp5e Regulated the Cilium-Related Genes Contributing to the Neural Tube Defects Under 5-Fluorouracil Exposure.Mol Neurobiol2024https://conductscience.org/library/papers/38285286PubMed
37,743,763Emerging principles of primary cilia dynamics in controlling tissue organization and function.EMBO J2023https://conductscience.org/library/papers/37743763PubMed
36,251,875Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling.Bioessays2022https://conductscience.org/library/papers/36251875PubMed
33,901,231Risk factors associated to neural tube defects among mothers who gave birth in North Shoa Zone Hospitals, Amhara Region, Ethiopia 2020: Case control study.PLoS One2021https://conductscience.org/library/papers/33901231PubMed
33,855,610Identification of new candidate genes for spina bifida through exome sequencing.Childs Nerv Syst2021https://conductscience.org/library/papers/33855610PubMed

Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CELSR19,620PubTator's text mininghttps://conductscience.org/library/genes/9620NCBI Gene
CELSR21,952PubTator's text mininghttps://conductscience.org/library/genes/1952NCBI Gene
CELSR31,951PubTator's text mininghttps://conductscience.org/library/genes/1951NCBI Gene
CXCR610,663PubTator's text mininghttps://conductscience.org/library/genes/10663NCBI Gene
GNAQ2,776PubTator's text mininghttps://conductscience.org/library/genes/2776NCBI Gene
GPR16123,432PubTator's text mininghttps://conductscience.org/library/genes/23432NCBI Gene
GPR166P442,206PubTator's text mininghttps://conductscience.org/library/genes/442206NCBI Gene
LPAR323,566PubTator's text mininghttps://conductscience.org/library/genes/23566NCBI Gene
RHO6,010PubTator's text mininghttps://conductscience.org/library/genes/6010NCBI Gene
SHH6,469PubTator's text mininghttps://conductscience.org/library/genes/6469NCBI Gene

1 to 10 of 12

See all 12 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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