ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 284401

Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody.

Karlsson FA and 3 others. Proc Natl Acad Sci U S A, 1979. Cited by 73 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. Papers, record 284401. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/284401

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1979
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
73
iCite
Relative citation ratio, by iCite
1.92
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Karlsson FAF A
2Van Obberghen EE
3Grunfeld CC
4Kahn CRC R

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
InsulinMajor topic
Receptor, InsulinMajor topic
Adipose Tissue
Animals
Antigen-Antibody Reactions
Biological Transport
Cells, Cultured
Glucose
Kinetics
Ligands
Mice
Oxidation-Reduction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1400,715Effects of antiinsulin receptor autoantibody on the metabolism of rat adipocytes.J Clin Endocrinol Metab1978https://conductscience.org/library/papers/400715PubMed
2648,762Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.Diabetologia1978https://conductscience.org/library/papers/648762PubMed
3279,910Direct demonstration that receptor crosslinking or aggregation is important in insulin action.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/279910PubMed
4661,952Insulin-dependent regulation of the insulin-sensitivity of adipocytes.Nature1978https://conductscience.org/library/papers/661952PubMed
5193,837Acquisition of increased hormone sensitivity during in vitro adipocyte development.J Biol Chem1977https://conductscience.org/library/papers/193837PubMed
6893,677Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.J Clin Invest1977https://conductscience.org/library/papers/893677PubMed
7908,753Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action.J Clin Invest1977https://conductscience.org/library/papers/908753PubMed
8189,659Receptors for peptide hormones. New insights into the pathophysiology of disease states in man.Ann Intern Med1977https://conductscience.org/library/papers/189659PubMed
9993,353Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man.J Clin Invest1976https://conductscience.org/library/papers/993353PubMed
10791,735The insulin receptor: its role in insulin resistance of obesity and diabetes.Diabetes1976https://conductscience.org/library/papers/791735PubMed

1 to 10 of 23

See all 23 references

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 73 citations.

PMIDTitleJournalYearIn PapersSource
40,247,011Insulin resistance in type 2 diabetes mellitus.Nat Rev Endocrinol2025https://conductscience.org/library/papers/40247011PubMed
38,372,750Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?Cell Mol Life Sci2024https://conductscience.org/library/papers/38372750PubMed
28,846,705Insulin modulates the frequency of Ca2+ oscillations in mouse pancreatic islets.PLoS One2017https://conductscience.org/library/papers/28846705PubMed
28,487,511A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations.Sci Rep2017https://conductscience.org/library/papers/28487511PubMed
28,235,104Phase modulation of insulin pulses enhances glucose regulation and enables inter-islet synchronization.PLoS One2017https://conductscience.org/library/papers/28235104PubMed
7,000,825Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.J Clin Invest1980https://conductscience.org/library/papers/7000825PubMed
6,371,815Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance.Proc Natl Acad Sci U S A1984https://conductscience.org/library/papers/6371815PubMed
6,350,362Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats.J Clin Invest1983https://conductscience.org/library/papers/6350362PubMed
6,278,475Prolactin-like activity of anti-prolactin receptor antibodies on casein and DNA synthesis in the mammary gland.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6278475PubMed
6,184,607Adipose cell differentiation in culture.Mol Cell Biochem1982https://conductscience.org/library/papers/6184607PubMed

1 to 10 of 17

See all 17 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
INSR3,643PubTator's text mininghttps://conductscience.org/library/genes/3643NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/284401

GET https://conductscience.org/api/papers/v1/284401/references?page=2

API referenceFor AI assistants