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Paper · 648762

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.

Le Marchand-Brustel Y and 4 others. Diabetologia, 1978. Cited by 45 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle. Papers, record 648762. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/648762

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle.
PubMed
Journal
Diabetologia
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
45
iCite
Relative citation ratio, by iCite
1.37
iCite
Revised in PubMed
2019-08-16
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Le Marchand-Brustel YY
2Gorden PP
3Flier JSJ S
4Kahn CRC R
5Freychet PP

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AutoantibodiesMajor topic
GlucoseMajor topic
MusclesMajor topic
Animals
Biological Transport
Glycogen
Glycolysis
Insulin Resistance
Male
Mice
Mice, Obese
Receptor, Insulin

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References10

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,137,321Thyroid-stimulating immunoglobulins in Graves' disease.Lancet1974https://conductscience.org/library/papers/4137321PubMed
2206,148Insulin binding and effects in isolated soleus muscle of lean and obese mice.Am J Physiol1978https://conductscience.org/library/papers/206148PubMed
3993,353Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man.J Clin Invest1976https://conductscience.org/library/papers/993353PubMed
4993,331Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice.J Clin Invest1976https://conductscience.org/library/papers/993331PubMed
5176,581The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.N Engl J Med1976https://conductscience.org/library/papers/176581PubMed
6893,677Autoantibodies to the insulin receptor. Effect on the insulin-receptor interaction in IM-9 lymphocytes.J Clin Invest1977https://conductscience.org/library/papers/893677PubMed
71,069,300Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/1069300PubMed
9170,678Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.Science1975https://conductscience.org/library/papers/170678PubMed
10908,753Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action.J Clin Invest1977https://conductscience.org/library/papers/908753PubMed
114,561,619The pentose cycle and insulin release in mouse pancreatic islets.Biochem J1972https://conductscience.org/library/papers/4561619PubMed

Cited by21

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 45 citations.

PMIDTitleJournalYearIn PapersSource
24,876,415Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.J Diabetes Sci Technol2014https://conductscience.org/library/papers/24876415PubMed
24,533,136Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.PLoS One2014https://conductscience.org/library/papers/24533136PubMed
24,423,625Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.MAbs2014https://conductscience.org/library/papers/24423625PubMed
22,403,294A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.Diabetes2012https://conductscience.org/library/papers/22403294PubMed
7,046,731Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes.Biochem J1982https://conductscience.org/library/papers/7046731PubMed
7,016,574Control of muscle insulin receptors by the motor nerve.Experientia1981https://conductscience.org/library/papers/7016574PubMed
7,000,825Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.J Clin Invest1980https://conductscience.org/library/papers/7000825PubMed
6,998,797Internalization of polypeptide hormones: mechanism, intracellular localization and significance.Diabetologia1980https://conductscience.org/library/papers/6998797PubMed
6,989,695Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans.Diabetologia1980https://conductscience.org/library/papers/6989695PubMed
6,269,936A partial view of the mechanism of insulin action.Diabetologia1981https://conductscience.org/library/papers/6269936PubMed

1 to 10 of 21

See all 21 cited by

Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
INSR3,643PubTator's text mininghttps://conductscience.org/library/genes/3643NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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