Paper · 1069300

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.

Jarrett DB and 3 others. Proc Natl Acad Sci U S A, 1976. Cited by 79 papers, by iCite.

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ConductScience Library. Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor. Papers, record 1069300. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1069300

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.; PubMed
Journal: Proc Natl Acad Sci U S A; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/1069300/; PubMed
DOI: https://doi.org/10.1073/pnas.73.11.4115; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC431349/; PubMed
The journal: https://conductscience.org/library/journal-index/7505876; PubMed
Citations, by iCite: 79; iCite
Relative citation ratio, by iCite: 2.37; iCite
Revised in PubMed: 2019-05-01; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Jarrett DB	D B
2	Roth J	J
3	Kahn CR	C R
4	Flier JS	J S

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Autoantibodies	Major topic
Insulin Resistance	Major topic
Lymphocytes	Major topic
Receptor, Insulin	Major topic
Antigen-Antibody Reactions
Binding, Competitive
Cells, Cultured
Diabetes Mellitus
Humans
Insulin
Kinetics

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References23

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	4,130,108	Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH.	J Immunol	1974	https://conductscience.org/library/papers/4130108	PubMed
2	4,179,068	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	Scand J Clin Lab Invest Suppl	1968	https://conductscience.org/library/papers/4179068	PubMed
3	5,290,016	Proliferation and differentiation of lymphoid cells: studies with human lymphoid cell lines and immunoglobulin synthesis.	Ann N Y Acad Sci	1971	https://conductscience.org/library/papers/5290016	PubMed
4	4,137,321	Thyroid-stimulating immunoglobulins in Graves' disease.	Lancet	1974	https://conductscience.org/library/papers/4137321	PubMed
5	4,359,334	Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.	Proc Natl Acad Sci U S A	1974	https://conductscience.org/library/papers/4359334	PubMed
6	4,361,817	Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay.	J Biol Chem	1974	https://conductscience.org/library/papers/4361817	PubMed
7	4,362,069	Quantitative aspects of the insulin-receptor interaction in liver plasma membranes.	J Biol Chem	1974	https://conductscience.org/library/papers/4362069	PubMed
8	4,331,561	Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.	Proc Natl Acad Sci U S A	1971	https://conductscience.org/library/papers/4331561	PubMed
9	4,575,923	125 I-labeled rat transplantation alloantibody. I. Preparation.	Transplantation	1973	https://conductscience.org/library/papers/4575923	PubMed
10	47,950	Myasthenia gravis: a serum factor blocking acetylcholine receptors of the human neuromuscular junction.	Lancet	1975	https://conductscience.org/library/papers/47950	PubMed

1 to 10 of 23

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Cited by22

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 79 citations.

PMID	Title	Journal	Year	In Papers	Source
11,215,279	Prognostic value of vascularity and vascular endothelial growth factor expression in non-small cell lung cancer.	J Clin Pathol	2001	https://conductscience.org/library/papers/11215279	PubMed
7,028,760	Surface redistribution of 125I-insulin in cultured human lymphocytes.	J Cell Biol	1981	https://conductscience.org/library/papers/7028760	PubMed
7,000,825	Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts.	J Clin Invest	1980	https://conductscience.org/library/papers/7000825	PubMed
6,998,797	Internalization of polypeptide hormones: mechanism, intracellular localization and significance.	Diabetologia	1980	https://conductscience.org/library/papers/6998797	PubMed
6,989,695	Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans.	Diabetologia	1980	https://conductscience.org/library/papers/6989695	PubMed
6,873,516	Immunoprecipitation of 125I-insulin crosslinked receptor.	Diabetologia	1983	https://conductscience.org/library/papers/6873516	PubMed
6,759,274	Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients.	Diabetologia	1982	https://conductscience.org/library/papers/6759274	PubMed
6,383,914	Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry.	Diabetologia	1984	https://conductscience.org/library/papers/6383914	PubMed
6,345,588	Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance.	J Clin Invest	1983	https://conductscience.org/library/papers/6345588	PubMed
6,298,962	Autoantibodies to hormone receptors.	Springer Semin Immunopathol	1982	https://conductscience.org/library/papers/6298962	PubMed

1 to 10 of 22

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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