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Paper · 28762014

Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention.

Ornelas A and 9 others. Cancer Metastasis Rev, 2017. Cited by 169 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Papers, record 28762014. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/28762014

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention.
PubMed
Journal
Cancer Metastasis Rev
PubMed
Year
2017
PubMed
Publication types
Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
169
iCite
Relative citation ratio, by iCite
7.01
iCite
Revised in PubMed
2025-07-23
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ornelas AArgentina
2Zacharias-Millward NNiki
3Menter DGDavid G
4Davis JSJennifer S
5Lichtenberger LLenard
6Hawke DDavid
7Hawk EErnest
8Vilar EEduardo
9Bhattacharya PPratip
10Millward SSteven

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AspirinMajor topic
Blood PlateletsMajor topic
Cyclooxygenase 1Major topic
NeoplasmsMajor topic
Animals
Anticarcinogenic Agents
Cyclooxygenase 2
Cyclooxygenase Inhibitors
Humans

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R25 CA057730NCI NIH HHSUnited StatesR25CA057730PubMed and NIHNIH RePORTER
R21 CA181994NCI NIH HHSUnited StatesR21CA181994PubMed and NIHNIH RePORTER
R01 CA172670NCI NIH HHSUnited StatesR01CA172670PubMed and NIHNIH RePORTER
KL2 TR000370NCATS NIH HHSUnited StatesKL2TR000370PubMedNIH RePORTER
R01 CA184843NCI NIH HHSUnited StatesR01CA184843PubMed and NIHNIH RePORTER
R01 CA187238NCI NIH HHSUnited StatesR01CA187238PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References137

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,517,822Aspirin and cancer risk: a quantitative review to 2011.Ann Oncol2012https://conductscience.org/library/papers/22517822PubMed
226,596,838Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53.Tumour Biol2016https://conductscience.org/library/papers/26596838PubMed
35,013,373Absorption kinetics of aspirin in man following oral administration of an aqueous solution.J Pharm Sci1972https://conductscience.org/library/papers/5013373PubMed
428,143,522ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.Trials2017https://conductscience.org/library/papers/28143522PubMed
510,966,456Cyclooxygenases: structural, cellular, and molecular biology.Annu Rev Biochem2000https://conductscience.org/library/papers/10966456PubMed
624,133,627Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial.Cancer Med2013https://conductscience.org/library/papers/24133627PubMed
74,173,352In vitro acetylation of plasma proteins, enzymes and DNA by aspirin.Nature1968https://conductscience.org/library/papers/4173352PubMed
84,208,101Drugs which inhibit prostaglandin biosynthesis.Pharmacol Rev1974https://conductscience.org/library/papers/4208101PubMed
916,258,079Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes.Drug Metab Dispos2006https://conductscience.org/library/papers/16258079PubMed
1015,031,212Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis.Blood2004https://conductscience.org/library/papers/15031212PubMed

1 to 10 of 137

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Cited by119

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 169 citations.

PMIDTitleJournalYearIn PapersSource
42,878,906Platelets as non-canonical immune regulatory nodes: orchestrating T cell dysfunction and immunotherapy resistance in cancer.Apoptosis2026https://conductscience.org/library/papers/42878906PubMed
42,747,715Prophylactic and therapeutic effects of aspirin in cancer.Clin Transl Oncol2026https://conductscience.org/library/papers/42747715PubMed
42,367,607Pregnancy-associated exposure reduction to medications used for antiphospholipid syndrome: a systematic review.EULAR Rheumatol Open2025https://conductscience.org/library/papers/42367607PubMed
42,154,376Uniform shear-induced platelet aggregation analysis via microfluidics fabricated from 3D-printed mold: a rapid platform for antiplatelet drug assessment.Anal Sci2026https://conductscience.org/library/papers/42154376PubMed
42,154,333Platelet-neutrophil cooperation in cancer: mechanisms of metastatic niche formation and implications for prognostic stratification and therapy.Cell Oncol (Dordr)2026https://conductscience.org/library/papers/42154333PubMed
42,126,251Design and Synthesis of Benzofuran-1,4-dihydropyridine Hybrids as Novel Anti-Inflammatory Agents: Theoretical Exploration of a Potential Dual COX-2/TNF-α Mechanism.Chem Biodivers2026https://conductscience.org/library/papers/42126251PubMed
42,004,350Piperazine-Thiourea Hybrids as Novel Antiplatelet Agents Targeting COX-1: Synthesis, in Vitro, and in Silico Evaluation.ACS Omega2026https://conductscience.org/library/papers/42004350PubMed
41,641,000Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer's disease.Front Aging Neurosci2025https://conductscience.org/library/papers/41641000PubMed
41,487,539Real-world evidence of the impact of aspirin use on esophageal cancer incidence in Barrett's esophagus patients.Proc (Bayl Univ Med Cent)2026https://conductscience.org/library/papers/41487539PubMed
41,398,295
Tumor-educated-platelets interact with breast cancer-stem-cells via P-selectin-PSGL1 and ensure stemness and metastasis through WNT-β-catenin-VEGF-VEGFR2 intra-cellular signaling: therapeutic modulation by aspirin.
Breast Cancer Res2025https://conductscience.org/library/papers/41398295PubMed

1 to 10 of 119

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Genes34

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213NCBI Gene
ANG283PubTator's text mininghttps://conductscience.org/library/genes/283NCBI Gene
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
CCL56,352PubTator's text mininghttps://conductscience.org/library/genes/6352NCBI Gene
CCN21,490PubTator's text mininghttps://conductscience.org/library/genes/1490NCBI Gene
COX8A1,351PubTator's text mininghttps://conductscience.org/library/genes/1351NCBI Gene
FGB2,244PubTator's text mininghttps://conductscience.org/library/genes/2244NCBI Gene
G6PD2,539PubTator's text mininghttps://conductscience.org/library/genes/2539NCBI Gene
GDF159,518PubTator's text mininghttps://conductscience.org/library/genes/9518NCBI Gene
GP1BA2,811PubTator's text mininghttps://conductscience.org/library/genes/2811NCBI Gene

1 to 10 of 34

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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