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Paper · 30718924

IL-10 produced by macrophages regulates epithelial integrity in the small intestine.

Morhardt TL and 11 others. Sci Rep, 2019. Cited by 101 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. IL-10 produced by macrophages regulates epithelial integrity in the small intestine. Papers, record 30718924. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30718924

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
IL-10 produced by macrophages regulates epithelial integrity in the small intestine.
PubMed
Journal
Sci Rep
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
101
iCite
Relative citation ratio, by iCite
4.1
iCite
Revised in PubMed
2020-08-28
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Morhardt TLTina L
2Hayashi AAtsushi
3Ochi TTakanori
4Quirós MMiguel
5Kitamoto SSho
6Nagao-Kitamoto HHiroko
7Kuffa PPeter
8Atarashi KKoji
9Honda KKenya
10Kao JYJohn Yhttps://orcid.org/0000-0003-1238-8324

1 to 10 of 12Source PubMed

See all 12 authors

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Interleukin-10Major topic
Intestinal MucosaMajor topic
Intestine, SmallMajor topic
MacrophagesMajor topic
Peptic UlcerMajor topic
RegenerationMajor topic
Animals
Anti-Inflammatory Agents, Non-Steroidal
Disease Models, Animal
Female
Gastrointestinal Microbiome
Humans
Indomethacin
Injections, Subcutaneous
Male
Mice
Mice, Knockout
Permeability
Specific Pathogen-Free Organisms

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 DK034933NIDDK NIH HHSUnited StatesP30DK034933PubMed and NIHNIH RePORTER
R01 DK055679NIDDK NIH HHSUnited StatesR01DK055679PubMed and NIHNIH RePORTER
R01 DK108901NIDDK NIH HHSUnited StatesR01DK108901PubMed and NIHNIH RePORTER
T32 DK094775NIDDK NIH HHSUnited StatesT32DK094775PubMed and NIHNIH RePORTER
R21 DK110146NIDDK NIH HHSUnited StatesR21DK110146PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,501,650Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs.N Engl J Med1992https://conductscience.org/library/papers/1501650PubMed
215,615,857Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/15615857PubMed
316,272,349Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.J Immunol2005https://conductscience.org/library/papers/16272349PubMed
417,873,879Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.Nat Immunol2007https://conductscience.org/library/papers/17873879PubMed
519,890,111Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.N Engl J Med2009https://conductscience.org/library/papers/19890111PubMed
619,917,501Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.Cell Host Microbe2009https://conductscience.org/library/papers/19917501PubMed
720,508,157Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice.Am J Physiol Gastrointest Liver Physiol2010https://conductscience.org/library/papers/20508157PubMed
821,051,439Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10.Int Immunol2010https://conductscience.org/library/papers/21051439PubMed
921,205,640Induction of colonic regulatory T cells by indigenous Clostridium species.Science2011https://conductscience.org/library/papers/21205640PubMed
1022,231,304Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.J Exp Med2012https://conductscience.org/library/papers/22231304PubMed

1 to 10 of 32

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Cited by74

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 101 citations.

PMIDTitleJournalYearIn PapersSource
42,609,442Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances.MedComm (2020)2026https://conductscience.org/library/papers/42609442PubMed
42,438,036Protective Effect of Uric Acid on Rat Model of Irritable Bowel Syndrome Requires Brain-Gut Communication Through Vagal Cholinergic Pathways.Neurogastroenterol Motil2026https://conductscience.org/library/papers/42438036PubMed
42,404,906AF6 orchestrates macrophage polarization via JAK2-STAT3 signaling and supports intestinal regeneration by stimulating stem cell proliferation.Front Immunol2026https://conductscience.org/library/papers/42404906PubMed
41,809,451Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV.World J Gastroenterol2026https://conductscience.org/library/papers/41809451PubMed
41,801,599Ethanolic extract of propolis attenuates inflammation and promotes mucosal repair in an indomethacin-induced murine model of enteropathy.Inflammopharmacology2026https://conductscience.org/library/papers/41801599PubMed
41,394,919Effects of Alpinia oxyphylla stems and leaves extracts on immune function, antioxidant function, and microbial flora composition in the intestinal tract of Jiaji ducks.Front Vet Sci2025https://conductscience.org/library/papers/41394919PubMed
41,353,317Recombinant MAM from Faecalibacterium duncaniae exhibits a protective effect in DNBS-induced colitis.Microb Cell Fact2025https://conductscience.org/library/papers/41353317PubMed
41,110,099Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages.FEBS J2025https://conductscience.org/library/papers/41110099PubMed
40,948,760Mechanisms and therapeutic strategies of macrophages and neutrophils inducing ulcerative colitis progression.Front Immunol2025https://conductscience.org/library/papers/40948760PubMed
40,681,534Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers.Sci Rep2025https://conductscience.org/library/papers/40681534PubMed

1 to 10 of 74

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Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCN48,840PubTator's text mininghttps://conductscience.org/library/genes/8840NCBI Gene
CD14929PubTator's text mininghttps://conductscience.org/library/genes/929NCBI Gene
CREB11,385PubTator's text mininghttps://conductscience.org/library/genes/1385NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
FCGR1A2,209PubTator's text mininghttps://conductscience.org/library/genes/2209NCBI Gene
HNF4A3,172PubTator's text mininghttps://conductscience.org/library/genes/3172NCBI Gene
IL103,586PubTator's text mininghttps://conductscience.org/library/genes/3586NCBI Gene
ITGAX3,687PubTator's text mininghttps://conductscience.org/library/genes/3687NCBI Gene
RAG15,896PubTator's text mininghttps://conductscience.org/library/genes/5896NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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