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Paper · 31300673

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.

Carlström KE and 16 others. Nat Commun, 2019. Cited by 118 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes. Papers, record 31300673. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/31300673

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.
PubMed
Journal
Nat Commun
PubMed
Year
2019
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
118
iCite
Relative citation ratio, by iCite
5.11
iCite
Revised in PubMed
2021-01-10
PubMed

Authors17

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Carlström KEKarl E
2Ewing EEwoudhttps://orcid.org/0000-0001-8644-366X
3Granqvist MMathias
4Gyllenberg AAlexandra
5Aeinehband SShahin
6Enoksson SLSara Lind
7Checa AAntonio
8Badam TVSTejaswi V S
9Huang JJesse
10Gomez-Cabrero DDavid

1 to 10 of 17Source PubMed

See all 17 authors

Topics20

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Dimethyl FumarateMajor topic
Immunosuppressive AgentsMajor topic
MonocytesMajor topic
Multiple Sclerosis, Relapsing-RemittingMajor topic
NADPH OxidasesMajor topic
Adult
DNA Methylation
Epigenesis, Genetic
Female
Humans
Leukocyte Count
Longitudinal Studies
Male
Middle Aged
NF-E2-Related Factor 2
Polymorphism, Single Nucleotide
Prospective Studies
Reactive Oxygen Species
T-Lymphocytes
Treatment Outcome

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT05112484Therapeutic Monitoring of Drugs Used in the Treatment of Multiple SclerosisBackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References67

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,992,073Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis.N Engl J Med2012https://conductscience.org/library/papers/22992073PubMed
216,814,112NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions.Free Radic Biol Med2006https://conductscience.org/library/papers/16814112PubMed
324,336,642ChAMP: 450k Chip Analysis Methylation Pipeline.Bioinformatics2014https://conductscience.org/library/papers/24336642PubMed
414,567,559Lymphocyte subpopulations, oxidative burst and apoptosis in peripheral blood cells of patients with multiple sclerosis-effect of interferon-beta.Autoimmunity2003https://conductscience.org/library/papers/14567559PubMed
526,767,188Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis.Neurol Neuroimmunol Neuroinflamm2016https://conductscience.org/library/papers/26767188PubMed
629,928,650The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis.Ann Clin Transl Neurol2018https://conductscience.org/library/papers/29928650PubMed
727,687,891Epigenetic Variability of CD4+CD25+ Tregs Contributes to the Pathogenesis of Autoimmune Diseases.Clin Rev Allergy Immunol2017https://conductscience.org/library/papers/27687891PubMed
821,848,345Isoprostane generation and function.Chem Rev2011https://conductscience.org/library/papers/21848345PubMed
925,738,172Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate.Neurol Neuroimmunol Neuroinflamm2015https://conductscience.org/library/papers/25738172PubMed
1022,257,669The sva package for removing batch effects and other unwanted variation in high-throughput experiments.Bioinformatics2012https://conductscience.org/library/papers/22257669PubMed

1 to 10 of 67

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Cited by82

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 118 citations.

PMIDTitleJournalYearIn PapersSource
42,957,749Transcription factor EB as a novel target for dimethyl fumarate to restore endothelial function in diabetes.Acta Pharmacol Sin2026https://conductscience.org/library/papers/42957749PubMed
42,593,635Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions.Neurol Ther2026https://conductscience.org/library/papers/42593635PubMed
42,047,854The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis.Acta Neuropathol2026https://conductscience.org/library/papers/42047854PubMed
41,881,983Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther2026https://conductscience.org/library/papers/41881983PubMed
41,639,279A HIF1A variant impacts long-term disability and smoldering inflammation in multiple sclerosis.Acta Neuropathol2026https://conductscience.org/library/papers/41639279PubMed
41,574,701MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review).Int J Mol Med2026https://conductscience.org/library/papers/41574701PubMed
41,383,596Metabolic reprogramming of macrophages in chronic obstructive pulmonary disease.Front Immunol2025https://conductscience.org/library/papers/41383596PubMed
41,339,603Nox3 expression and function in retinal ganglion cells and Amacrine cells.Cell Mol Life Sci2025https://conductscience.org/library/papers/41339603PubMed
41,281,740Macrophage Immunometabolism in Pulmonary Homeostasis and Chronic Lung Diseases.Int J Biol Sci2025https://conductscience.org/library/papers/41281740PubMed
40,722,916Alzheimer's Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria-Associated Metabolic Pathways Through Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2).Antioxidants (Basel)2025https://conductscience.org/library/papers/40722916PubMed

1 to 10 of 82

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Genes33

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CCL2856,477PubTator's text mininghttps://conductscience.org/library/genes/56477NCBI Gene
CCL46,351PubTator's text mininghttps://conductscience.org/library/genes/6351NCBI Gene
CCR2729,230PubTator's text mininghttps://conductscience.org/library/genes/729230NCBI Gene
CCR71,236PubTator's text mininghttps://conductscience.org/library/genes/1236NCBI Gene
CD14929PubTator's text mininghttps://conductscience.org/library/genes/929NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
CDCP164,866PubTator's text mininghttps://conductscience.org/library/genes/64866NCBI Gene
CLCN71,186PubTator's text mininghttps://conductscience.org/library/genes/1186NCBI Gene
CREBBP1,387PubTator's text mininghttps://conductscience.org/library/genes/1387NCBI Gene

1 to 10 of 33

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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