Paper · 33705692
3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain.
Doyle AD and 4 others. Dev Cell, 2021. Cited by 85 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. 3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain. Papers, record 33705692. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33705692
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- 3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain.
- PubMed
Topics11
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Breast Neoplasms | Major topic |
| Cell Movement | Major topic |
| Extracellular Matrix | Major topic |
| Fibroblasts | Major topic |
| Mesoderm | Major topic |
| Nonmuscle Myosin Type IIA | Major topic |
| Stress, Mechanical | Major topic |
| Cell Adhesion | |
| Cells, Cultured | |
| Female | |
| Humans |
Source PubMed
Grants5
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| R00 CA226366 | NCI NIH HHS | United States | R00CA226366 | PubMed and NIH | NIH RePORTER |
| Z99 DE999999 | Intramural NIH HHS | United States | Z99DE999999 | PubMed | NIH RePORTER |
| ZIC DE000750 | Intramural NIH HHS | United States | ZICDE000750 | PubMed | NIH RePORTER |
| ZIADE000524 | NIH | NIH RePORTER | |||
| ZIADE000718 | NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections1
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
| Kind | PMID | Title | In Papers |
|---|---|---|---|
| Comment in | 33,756,118 | Engaging the front wheels to drive through fibrous terrain. | https://conductscience.org/library/papers/33756118 |
Source PubMed
References47
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 11,721,053 | Taking cell-matrix adhesions to the third dimension. | Science | 2001 | https://conductscience.org/library/papers/11721053 | PubMed |
| 2 | 22,547,408 | Nonpolarized signaling reveals two distinct modes of 3D cell migration. | J Cell Biol | 2012 | https://conductscience.org/library/papers/22547408 | PubMed |
| 3 | 31,582,855 | Mechanisms of 3D cell migration. | Nat Rev Mol Cell Biol | 2019 | https://conductscience.org/library/papers/31582855 | PubMed |
| 4 | 28,381,423 | Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. | Mol Biol Cell | 2017 | https://conductscience.org/library/papers/28381423 | PubMed |
| 5 | 29,316,444 | Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. | Dev Cell | 2018 | https://conductscience.org/library/papers/29316444 | PubMed |
| 6 | 27,872,289 | Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs. | Proc Natl Acad Sci U S A | 2016 | https://conductscience.org/library/papers/27872289 | PubMed |
| 7 | 22,797,913 | United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction. | J Cell Sci | 2012 | https://conductscience.org/library/papers/22797913 | PubMed |
| 8 | 31,091,287 | Fiber alignment drives changes in architectural and mechanical features in collagen matrices. | PLoS One | 2019 | https://conductscience.org/library/papers/31091287 | PubMed |
| 9 | 15,654,332 | Basic mechanism of three-dimensional collagen fibre transport by fibroblasts. | Nat Cell Biol | 2005 | https://conductscience.org/library/papers/15654332 | PubMed |
| 10 | 457,780 | Induction of spreading during fibroblast movement. | J Cell Biol | 1979 | https://conductscience.org/library/papers/457780 | PubMed |
1 to 10 of 47
See all 47 referencesCited by59
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 85 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,406,588 | Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential. | Adv Healthc Mater | 2026 | https://conductscience.org/library/papers/42406588 | PubMed |
| 42,349,051 | Physical continuity at biomaterial-ECM interfaces is associated with reduced fibroblast activation and NF-κB signaling. | Biomaterials | 2026 | https://conductscience.org/library/papers/42349051 | PubMed |
| 41,961,858 | Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity. | Proc Natl Acad Sci U S A | 2026 | https://conductscience.org/library/papers/41961858 | PubMed |
| 41,623,944 | Tunable viscoelastic collagen/polyethylene glycol composite hydrogels modulate neural and tumor cell behavior in 3D microenvironments. | Biomater Transl | 2025 | https://conductscience.org/library/papers/41623944 | PubMed |
| 41,461,906 | Guidance for 3D traction force microscopy today and in the next decade. | Nat Methods | 2026 | https://conductscience.org/library/papers/41461906 | PubMed |
| 41,296,811 | Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment. | PLoS Comput Biol | 2025 | https://conductscience.org/library/papers/41296811 | PubMed |
| 40,919,425 | The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity. | NPJ Biol Phys Mech | 2025 | https://conductscience.org/library/papers/40919425 | PubMed |
| 40,893,357 | The role of non-linear viscoelastic hydrogel mechanics in cell culture and transduction. | Mater Today Bio | 2025 | https://conductscience.org/library/papers/40893357 | PubMed |
| 40,664,976 | Migrating immune cells globally coordinate protrusive forces. | Nat Immunol | 2025 | https://conductscience.org/library/papers/40664976 | PubMed |
| 40,656,546 | Cancer-Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets. | MedComm (2020) | 2025 | https://conductscience.org/library/papers/40656546 | PubMed |
1 to 10 of 59
See all 59 cited byGenes11
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ACTN1 | 87 | PubTator's text mining | https://conductscience.org/library/genes/87 | NCBI Gene |
| AKT1 | 207 | PubTator's text mining | https://conductscience.org/library/genes/207 | NCBI Gene |
| CDC42 | 998 | PubTator's text mining | https://conductscience.org/library/genes/998 | NCBI Gene |
| FGF2 | 2,247 | PubTator's text mining | https://conductscience.org/library/genes/2247 | NCBI Gene |
| ITGB1 | 3,688 | PubTator's text mining | https://conductscience.org/library/genes/3688 | NCBI Gene |
| MYH10 | 4,628 | PubTator's text mining | https://conductscience.org/library/genes/4628 | NCBI Gene |
| MYH14 | 79,784 | PubTator's text mining | https://conductscience.org/library/genes/79784 | NCBI Gene |
| MYH9 | 4,627 | PubTator's text mining | https://conductscience.org/library/genes/4627 | NCBI Gene |
| PXN | 5,829 | PubTator's text mining | https://conductscience.org/library/genes/5829 | NCBI Gene |
| RHOA | 387 | PubTator's text mining | https://conductscience.org/library/genes/387 | NCBI Gene |
1 to 10 of 11
See all 11 genesDrugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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