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Paper · 33754043

FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells.

Wang J and 20 others. Theranostics, 2021. Cited by 44 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. Papers, record 33754043. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33754043

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells.
PubMed
Journal
Theranostics
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
44
iCite
Relative citation ratio, by iCite
2.46
iCite
Revised in PubMed
2021-08-02
PubMed

Authors21

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wang JJingchun
2Zhao HHuakan
3Zheng LLu
4Zhou YYu
5Wu LLei
6Xu YYanquan
7Zhang XXiao
8Yan GGuifang
9Sheng HHalei
10Xin RRong

1 to 10 of 21Source PubMed

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Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Calcium SignalingMajor topic
Carcinoma, HepatocellularMajor topic
Cell Self RenewalMajor topic
Fibroblast Growth FactorsMajor topic
Liver NeoplasmsMajor topic
NFATC Transcription FactorsMajor topic
Neoplastic Stem CellsMajor topic
Cell Line, Tumor
Humans
MAP Kinase Signaling System
Phospholipase C gamma
Signal Transduction

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References60

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
118,723,449Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes.Circ Res2008https://conductscience.org/library/papers/18723449PubMed
231,114,916WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs.Nucleic Acids Res2019https://conductscience.org/library/papers/31114916PubMed
322,473,773Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.Hepatology2012https://conductscience.org/library/papers/22473773PubMed
424,393,342Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations.Liver Int2014https://conductscience.org/library/papers/24393342PubMed
527,632,571FGF2 and EGF Are Required for Self-Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells.J Cell Biochem2017https://conductscience.org/library/papers/27632571PubMed
630,085,405NFATc1 is a tumor suppressor in hepatocellular carcinoma and induces tumor cell apoptosis by activating the FasL-mediated extrinsic signaling pathway.Cancer Med2018https://conductscience.org/library/papers/30085405PubMed
729,184,418FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry.Onco Targets Ther2017https://conductscience.org/library/papers/29184418PubMed
815,866,891STIM1, an essential and conserved component of store-operated Ca2+ channel function.J Cell Biol2005https://conductscience.org/library/papers/15866891PubMed
917,361,175The molecular choreography of a store-operated calcium channel.Nature2007https://conductscience.org/library/papers/17361175PubMed
1031,040,921NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4.Oncotarget2019https://conductscience.org/library/papers/31040921PubMed

1 to 10 of 60

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Cited by34

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 44 citations.

PMIDTitleJournalYearIn PapersSource
42,848,145Cancer-associated mitochondrial homeostasis disrupted and retrograde signaling activated.Med Oncol2026https://conductscience.org/library/papers/42848145PubMed
42,633,326Advances in FGF/FGFR Signaling: Implications for Disease and Therapy.MedComm (2020)2026https://conductscience.org/library/papers/42633326PubMed
42,491,058The role of FGF19-FGFR4 signaling pathway in liver health and disease: Guardian or destroyer.Genes Dis2026https://conductscience.org/library/papers/42491058PubMed
42,463,639Dual-faced metabolic reprogramming powers proliferation: FGF21 drives lung squamous carcinoma progression via CaMKII-DRP1-mediated mitochondrial fission.Cell Death Dis2026https://conductscience.org/library/papers/42463639PubMed
42,445,406SDF4: a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma revealed by integrated multi‑omics analysis.Transl Cancer Res2026https://conductscience.org/library/papers/42445406PubMed
42,387,364Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy.Animal Model Exp Med2026https://conductscience.org/library/papers/42387364PubMed
41,832,306FGF family in health and disease.Mol Biomed2026https://conductscience.org/library/papers/41832306PubMed
41,749,109Gene expression regulation by Ca2+ signaling: an updated systematic review.Cell Mol Biol Lett2026https://conductscience.org/library/papers/41749109PubMed
41,328,353FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities.Theranostics2026https://conductscience.org/library/papers/41328353PubMed
41,146,849Regulation of Histone Acetylation During Inflammation Resolution.Immunotargets Ther2025https://conductscience.org/library/papers/41146849PubMed

1 to 10 of 34

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Genes34

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213NCBI Gene
ALDH1A1216PubTator's text mininghttps://conductscience.org/library/genes/216NCBI Gene
CALM1801PubTator's text mininghttps://conductscience.org/library/genes/801NCBI Gene
CAMK2G818PubTator's text mininghttps://conductscience.org/library/genes/818NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
FGF199,965PubTator's text mininghttps://conductscience.org/library/genes/9965NCBI Gene
FGF22,247PubTator's text mininghttps://conductscience.org/library/genes/2247NCBI Gene
FGF42,249PubTator's text mininghttps://conductscience.org/library/genes/2249NCBI Gene

1 to 10 of 34

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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