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Paper · 36077281

α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions.

Ablinger C and 6 others. Int J Mol Sci, 2022. Cited by 9 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions. Papers, record 36077281. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36077281

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions.
PubMed
Journal
Int J Mol Sci
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
9
iCite
Relative citation ratio, by iCite
0.68
iCite
Revised in PubMed
2026-07-28
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ablinger CCorneliahttps://orcid.org/0000-0003-2996-0913
2Eibl CClarissahttps://orcid.org/0000-0001-8248-5133
3Geisler SMStefanie Mhttps://orcid.org/0000-0002-8898-0108
4Campiglio MMartahttps://orcid.org/0000-0002-9629-2073
5Stephens GJGary Jhttps://orcid.org/0000-0002-8966-4238
6Missler MMarkushttps://orcid.org/0000-0001-8008-984X
7Obermair GJGerald J

Source PubMed

Topics5

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Calcium ChannelsMajor topic
NeuronsMajor topic
Hippocampus
Neurogenesis
Synapses

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
DOC 30Austrian Science Fund FWFAustriaPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
130,054,448Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.J Cell Biol2018https://conductscience.org/library/papers/30054448PubMed
233,679,366Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit α2δ-2 Mutant (Ducky) and α2δ Double Knockout Mice.Front Synaptic Neurosci2021https://conductscience.org/library/papers/33679366PubMed
331,908,000Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.FASEB J2020https://conductscience.org/library/papers/31908000PubMed
432,086,258α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse.J Neurosci2020https://conductscience.org/library/papers/32086258PubMed
525,146,647The evolution of the four subunits of voltage-gated calcium channels: ancient roots, increasing complexity, and multiple losses.Genome Biol Evol2014https://conductscience.org/library/papers/25146647PubMed
620,383,002Features and development of Coot.Acta Crystallogr D Biol Crystallogr2010https://conductscience.org/library/papers/20383002PubMed
719,818,485Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.Cell2009https://conductscience.org/library/papers/19818485PubMed
830,792,272Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.J Neurosci2019https://conductscience.org/library/papers/30792272PubMed
915,090,038Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons.Eur J Neurosci2004https://conductscience.org/library/papers/15090038PubMed
1032,607,809Neuronal α2δ proteins and brain disorders.Pflugers Arch2020https://conductscience.org/library/papers/32607809PubMed

1 to 10 of 49

See all 49 references

Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 9 citations.

PMIDTitleJournalYearIn PapersSource
40,664,238Biochemistry and physiology of voltage-gated calcium channel trafficking: a target for gabapentinoid drugs.Open Biol2025https://conductscience.org/library/papers/40664238PubMed
40,352,223Identification of differentially expressed genes in resting human skeletal muscle of sedentary versus strength and endurance- trained individuals using bioinformatics analysis and in vitro validation.Narra J2025https://conductscience.org/library/papers/40352223PubMed
39,770,450Autism-Linked Mutations in α2δ-1 and α2δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling.Pharmaceuticals (Basel)2024https://conductscience.org/library/papers/39770450PubMed
39,161,180A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2.J Neurochem2025https://conductscience.org/library/papers/39161180PubMed
38,158,856Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalities.Genet Med2024https://conductscience.org/library/papers/38158856PubMed
37,497,454An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity.Bio Protoc2023https://conductscience.org/library/papers/37497454PubMed
36,735,378The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity.Channels (Austin)2023https://conductscience.org/library/papers/36735378PubMed

Genes6

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CACHD157,685PubTator's text mininghttps://conductscience.org/library/genes/57685NCBI Gene
CACNA1A773PubTator's text mininghttps://conductscience.org/library/genes/773NCBI Gene
CACNA1B774PubTator's text mininghttps://conductscience.org/library/genes/774NCBI Gene
CACNA1F778PubTator's text mininghttps://conductscience.org/library/genes/778NCBI Gene
CACNA2D493,589PubTator's text mininghttps://conductscience.org/library/genes/93589NCBI Gene
IGKV2D-3028,881PubTator's text mininghttps://conductscience.org/library/genes/28881NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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