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Paper · 39715985

Aerobic exercise timing affects mitochondrial dynamics and insulin resistance by regulating the circadian clock protein expression and NAD+-SIRT1-PPARα-MFN2 pathway in the skeletal muscle of high-fat-diet-induced diabetes mice.

Pourabdi R and 3 others. J Physiol Biochem, 2025. Cited by 21 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Aerobic exercise timing affects mitochondrial dynamics and insulin resistance by regulating the circadian clock protein expression and NAD+-SIRT1-PPARα-MFN2 pathway in the skeletal muscle of high-fat-diet-induced diabetes mice. Papers, record 39715985. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/39715985

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Aerobic exercise timing affects mitochondrial dynamics and insulin resistance by regulating the circadian clock protein expression and NAD+-SIRT1-PPARα-MFN2 pathway in the skeletal muscle of high-fat-diet-induced diabetes mice.
PubMed
Journal
J Physiol Biochem
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
21
iCite
Relative citation ratio, by iCite
6.32, provisional
iCite
Revised in PubMed
2026-11-02
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pourabdi RRahahttps://orcid.org/0000-0001-6613-3138
2Shahidi FFereshtehhttps://orcid.org/0000-0001-6593-4435
3Tabandeh MRMohammad Rezahttps://orcid.org/0000-0003-3258-8550
4Salehpour MMojtabahttps://orcid.org/0000-0002-6208-2502

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Muscle, SkeletalMajor topic
Physical Conditioning, AnimalMajor topic
Diabetes Mellitus, ExperimentalMajor topic
Mitochondrial DynamicsMajor topic
Insulin ResistanceMajor topic
Circadian ClocksMajor topic
Animals
Sirtuin 1
Male
PPAR alpha
Diet, High-Fat
Mice
GTP Phosphohydrolases
NAD
Mitochondrial Proteins
Signal Transduction
Mice, Inbred C57BL

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References48

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
133,425,218Exercise Improves Endothelial Function Associated with Alleviated Inflammation and Oxidative Stress of Perivascular Adipose Tissue in Type 2 Diabetic Mice.Oxid Med Cell Longev2020https://conductscience.org/library/papers/33425218PubMed
224,567,902Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.Mol Metab2014https://conductscience.org/library/papers/24567902PubMed
32,679,125Differential roles of splanchnic and peripheral tissues in determining diurnal fluctuation of glucose tolerance.Am J Physiol1989https://conductscience.org/library/papers/2679125PubMed
435,318,101Nicotinamide riboside promotes Mfn2-mediated mitochondrial fusion in diabetic hearts through the SIRT1-PGC1α-PPARα pathway.Free Radic Biol Med2022https://conductscience.org/library/papers/35318101PubMed
523,562,075Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.Cell Metab2013https://conductscience.org/library/papers/23562075PubMed
626,365,180Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.Cell Metab2015https://conductscience.org/library/papers/26365180PubMed
735,227,728Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice.Metabolism2022https://conductscience.org/library/papers/35227728PubMed
827,084,533The mammalian circadian clock and its entrainment by stress and exercise.J Physiol Sci2017https://conductscience.org/library/papers/27084533PubMed
919,887,595Skeletal muscle NAMPT is induced by exercise in humans.Am J Physiol Endocrinol Metab2010https://conductscience.org/library/papers/19887595PubMed
1027,990,019Transcriptional architecture of the mammalian circadian clock.Nat Rev Genet2017https://conductscience.org/library/papers/27990019PubMed

1 to 10 of 48

See all 48 references

Cited by17

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 21 citations.

PMIDTitleJournalYearIn PapersSource
42,714,849SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB J2026https://conductscience.org/library/papers/42714849PubMed
42,646,283Rhythmic Metabolism in Osteosarcopenia: Emerging Evidence, a Chronometabolomic Framework for the Bone-Muscle Unit, and Research Priorities.Metabolites2026https://conductscience.org/library/papers/42646283PubMed
42,589,377Bidirectional Mechanisms Linking Circadian Rhythm Disruption and Parkinson's Disease: Chronobiomarkers and Therapeutic Implications.Int J Mol Sci2026https://conductscience.org/library/papers/42589377PubMed
42,276,052Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction.Cell Rep Med2026https://conductscience.org/library/papers/42276052PubMed
42,196,395Exercise Timing in Sport: Molecular and Physiological Mechanisms Linking Performance, Recovery, and Biological Cost.Int J Mol Sci2026https://conductscience.org/library/papers/42196395PubMed
42,133,257Chrono overexpression blunts exercise-induced improvement in muscular glucose metabolism by inhibiting the BMAL1 transcriptional activity in high-fat diet-fed mice.J Physiol Biochem2026https://conductscience.org/library/papers/42133257PubMed
41,930,287Timing-dependent effects of green tea supplementation and exercise intensity on oxidative stress in diabetic rats: a 2 × 2 × 2 factorial study.Front Sports Act Living2026https://conductscience.org/library/papers/41930287PubMed
41,845,069Time-of-day-dependent effects of exercise on the hepatic clock and proteome in high-fat diet-fed mice.J Physiol Biochem2026https://conductscience.org/library/papers/41845069PubMed
41,594,656BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus.Biomolecules2026https://conductscience.org/library/papers/41594656PubMed
41,313,529Potential Mechanisms of Exercise-Mediated Ferroptosis Regulation in Central Nervous System Diseases.Mol Neurobiol2025https://conductscience.org/library/papers/41313529PubMed

1 to 10 of 17

See all 17 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMAL1406PubTator's text mininghttps://conductscience.org/library/genes/406NCBI Gene
DNM1L10,059PubTator's text mininghttps://conductscience.org/library/genes/10059NCBI Gene
MFN29,927PubTator's text mininghttps://conductscience.org/library/genes/9927NCBI Gene
PER28,864PubTator's text mininghttps://conductscience.org/library/genes/8864NCBI Gene
PPARA5,465PubTator's text mininghttps://conductscience.org/library/genes/5465NCBI Gene
SIRT123,411PubTator's text mininghttps://conductscience.org/library/genes/23411NCBI Gene
SLC2A46,517PubTator's text mininghttps://conductscience.org/library/genes/6517NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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