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Paper · 41129595

A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat.

Jiang T and 11 others. PLoS Genet, 2025. Cited by 4 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat. Papers, record 41129595. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41129595

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat.
PubMed
Journal
PLoS Genet
PubMed
Year
2025
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
4
iCite
Revised in PubMed
2026-03-25
PubMed

Authors12

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Jiang TTingting
2Su DDuohttps://orcid.org/0000-0002-1308-5862
3Ke JJinghttps://orcid.org/0009-0007-9560-5334
4Dai XXin
5Wang MMaohuahttps://orcid.org/0009-0008-9585-2383
6Wang YYan
7Zhan SSiyuanhttps://orcid.org/0000-0003-3449-9682
8Zhong TTao
9Guo JJiazhong
10Li LLi

1 to 10 of 12Source PubMed

See all 12 authors

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adipose Tissue, BrownMajor topic
PPAR alphaMajor topic
Enhancer Elements, GeneticMajor topic
MitochondriaMajor topic
Male
Animals
Mice
Mice, Inbred C57BL
Chromatin
Promoter Regions, Genetic
Cold Temperature
Thermogenesis
Cyclic AMP Response Element-Binding Protein
Uncoupling Protein 1
Adipocytes
Adipose Tissue, White

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References70

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
137,095,199Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues.Acta Pharmacol Sin2023https://conductscience.org/library/papers/37095199PubMed
227,230,905Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice.Physiol Rep2016https://conductscience.org/library/papers/27230905PubMed
330,033,199Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice.Cell Metab2018https://conductscience.org/library/papers/30033199PubMed
439,789,228Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat.Commun Biol2025https://conductscience.org/library/papers/39789228PubMed
531,106,371CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing.Nucleic Acids Res2019https://conductscience.org/library/papers/31106371PubMed
616,125,138Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue.Biochem Biophys Res Commun2005https://conductscience.org/library/papers/16125138PubMed
720,393,465Widespread transcription at neuronal activity-regulated enhancers.Nature2010https://conductscience.org/library/papers/20393465PubMed
833,377,014Isolation, Culture, and Functional Analysis of Murine Thermogenic Adipocytes.STAR Protoc2020https://conductscience.org/library/papers/33377014PubMed
925,979,474WGE: a CRISPR database for genome engineering.Bioinformatics2015https://conductscience.org/library/papers/25979474PubMed
1029,153,407Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.Cell Metab2018https://conductscience.org/library/papers/29153407PubMed

1 to 10 of 70

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Cited by3

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 4 citations.

PMIDTitleJournalYearIn PapersSource
42,511,610Alternative Receptor Signaling for the Selective and Multifaceted Regulation of Human Brown Adipocytes.Int J Mol Sci2026https://conductscience.org/library/papers/42511610PubMed
42,368,353Mechanisms of energy metabolism reprogramming and homeostasis maintenance in overwintering hibernating animals.Front Vet Sci2026https://conductscience.org/library/papers/42368353PubMed
42,221,955Brown adipose tissue in ruminants: development, thermogenic function, and nutritional regulation.Front Vet Sci2026https://conductscience.org/library/papers/42221955PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CREB11,385PubTator's text mininghttps://conductscience.org/library/genes/1385NCBI Gene
CREBBP1,387PubTator's text mininghttps://conductscience.org/library/genes/1387NCBI Gene
PPARA5,465PubTator's text mininghttps://conductscience.org/library/genes/5465NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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