Paper · 41959461

High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition.

Lee AA and 5 others. bioRxiv, 2026. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition. Papers, record 41959461. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41959461

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition.; PubMed
Journal: bioRxiv; PubMed
Year: 2026; PubMed
Publication types: Journal Article, Preprint; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41959461/; PubMed
DOI: https://doi.org/10.64898/2026.03.30.715055; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC13060101/; PubMed
The journal: https://conductscience.org/library/journal-index/101680187; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2026-09-22; PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Lee AA	Albert A	https://orcid.org/0000-0002-7238-1274
2	Mokhtari DA	Daniel A	https://orcid.org/0000-0003-4206-9471
3	Egan ED	Emily D
4	Blacklow SC	Stephen C	https://orcid.org/0000-0002-6904-1981
5	Herschlag D	Daniel	https://orcid.org/0000-0002-4685-1973
6	Fordyce PM	Polly M	https://orcid.org/0000-0002-9505-0638

Source PubMed

Topics0

NLM's MeSH indexing of the paper, its major topics first.

None in this release.

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 CA272484	NCI NIH HHS	United States	R01CA272484	PubMed	NIH RePORTER
R01 GM064798	NIGMS NIH HHS	United States	R01GM064798	PubMed	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References93

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	34,554,789	From variant to function in human disease genetics.	Science	2021	https://conductscience.org/library/papers/34554789	PubMed
2	16,369,543	A role for the scaffolding adapter GAB2 in breast cancer.	Nat Med	2006	https://conductscience.org/library/papers/16369543	PubMed
3	30,375,388	Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.	Nat Commun	2018	https://conductscience.org/library/papers/30375388	PubMed
4	29,877,794	An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.	Elife	2018	https://conductscience.org/library/papers/29877794	PubMed
5	38,928,272	Folding and Binding Kinetics of the Tandem of SH2 Domains from SHP2.	Int J Mol Sci	2024	https://conductscience.org/library/papers/38928272	PubMed
6	23,582,321	Allostery in disease and in drug discovery.	Cell	2013	https://conductscience.org/library/papers/23582321	PubMed
7	33,002,410	Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.	Cell	2020	https://conductscience.org/library/papers/33002410	PubMed
8	27,030,275	Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.	Biochemistry	2016	https://conductscience.org/library/papers/27030275	PubMed
9	21,396,583	Noonan syndrome and clinically related disorders.	Best Pract Res Clin Endocrinol Metab	2011	https://conductscience.org/library/papers/21396583	PubMed
10	12,654,249	Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.	Cell	2003	https://conductscience.org/library/papers/12654249	PubMed

1 to 10 of 93

See all 93 references

Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

PMID	Title	Journal	Year	In Papers
42,929,068	Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations.	Biochem J	2026	https://conductscience.org/library/papers/42929068

Source PubMed

Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes
PTPN11	5,781	PubTator's text mining	https://conductscience.org/library/genes/5781

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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