Paper · 16369543

A role for the scaffolding adapter GAB2 in breast cancer.

Bentires-Alj M and 9 others. Nat Med, 2006. Cited by 172 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A role for the scaffolding adapter GAB2 in breast cancer. Papers, record 16369543. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16369543

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: A role for the scaffolding adapter GAB2 in breast cancer.; PubMed
Journal: Nat Med; PubMed
Year: 2006; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/16369543/; PubMed
DOI: https://doi.org/10.1038/nm1341; PubMed
The journal: https://conductscience.org/library/journal-index/9502015; PubMed
Citations, by iCite: 172; iCite
Relative citation ratio, by iCite: 3.01; iCite
Revised in PubMed: 2026-01-28; PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Bentires-Alj M	Mohamed
2	Gil SG	Susana G
3	Chan R	Richard
4	Wang ZC	Zhigang C
5	Wang Y	Yongping
6	Imanaka N	Naoko
7	Harris LN	Lyndsay N
8	Richardson A	Andrea
9	Neel BG	Benjamin G
10	Gu H	Haihua

Source PubMed

Topics31

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Breast Neoplasms	Major topic
Gene Expression Regulation, Neoplastic	Major topic
Mammary Neoplasms, Animal	Major topic
Phosphoproteins	Major topic
Erb-b2 Receptor Tyrosine Kinases	Major topic
Adaptor Proteins, Signal Transducing
Animals
Cell Culture Techniques
Cell Line
Cell Line, Tumor
Chromosome Mapping
Crosses, Genetic
Extracellular Signal-Regulated MAP Kinases
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Intracellular Signaling Peptides and Proteins
Ki-67 Antigen
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Fluorescence
Neoplasm Invasiveness
Phenotype
Phosphorylation
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases
Retroviridae
Time Factors

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
AI 51612	NIAID NIH HHS	United States	R01AI051612	PubMed and NIH	NIH RePORTER
DK50693	NIDDK NIH HHS	United States	R01DK050693	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by119

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 172 citations.

PMID	Title	Journal	Year	In Papers	Source
42,979,455	The conformational-condensate code of GRB2: State switching, spatial organization, and therapeutic windows.	Acta Pharm Sin B	2026	https://conductscience.org/library/papers/42979455	PubMed
41,986,333	Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs.	Nat Commun	2026	https://conductscience.org/library/papers/41986333	PubMed
41,959,461	High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition.	bioRxiv	2026	https://conductscience.org/library/papers/41959461	PubMed
41,028,199	Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases.	Nat Rev Mol Cell Biol	2026	https://conductscience.org/library/papers/41028199	PubMed
40,910,271	DBN1‑mediated upregulation of GAB2 facilitates the migration and invasion of T‑cell acute lymphoblastic leukemia cells.	Oncol Rep	2025	https://conductscience.org/library/papers/40910271	PubMed
40,849,687	The Functional Interplay among GAD2, GABRG2, and CACNA1G Genes in Cancers.	Asian Pac J Cancer Prev	2025	https://conductscience.org/library/papers/40849687	PubMed
40,595,497	Deep mutational scanning of the multi-domain phosphatase SHP2 reveals mechanisms of regulation and pathogenicity.	Nat Commun	2025	https://conductscience.org/library/papers/40595497	PubMed
40,377,959	A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein-Protein Interaction Implicated in Breast Cancer.	Chembiochem	2025	https://conductscience.org/library/papers/40377959	PubMed
39,959,686	Complex Roles of PTPN11/SHP2 in Carcinogenesis and Prospect of Targeting SHP2 in Cancer Therapy.	Annu Rev Cancer Biol	2024	https://conductscience.org/library/papers/39959686	PubMed
39,175,664	GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease.	Biochem Biophys Rep	2024	https://conductscience.org/library/papers/39175664	PubMed

1 to 10 of 119

See all 119 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ERBB2	2,064	PubTator's text mining	https://conductscience.org/library/genes/2064	NCBI Gene
GAB2	9,846	PubTator's text mining	https://conductscience.org/library/genes/9846	NCBI Gene
MAPK1	5,594	PubTator's text mining	https://conductscience.org/library/genes/5594	NCBI Gene
PTPN11	5,781	PubTator's text mining	https://conductscience.org/library/genes/5781	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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