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Paper · 30375388

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.

LaRochelle JR and 9 others. Nat Commun, 2018. Cited by 150 papers, by iCite.

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ConductScience Library. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Papers, record 30375388. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30375388

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.
PubMed
Journal
Nat Commun
PubMed
Year
2018
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
150
iCite
Relative citation ratio, by iCite
4.78
iCite
Revised in PubMed
2019-10-30
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1LaRochelle JRJonathan Rhttps://orcid.org/0000-0002-3301-7904
2Fodor MMichelle
3Vemulapalli VVidyasiri
4Mohseni MMorvaridhttps://orcid.org/0000-0002-0964-924X
5Wang PPing
6Stams TTravis
7LaMarche MJMatthew J
8Chopra RRajiv
9Acker MGMichael G
10Blacklow SCStephen Chttps://orcid.org/0000-0002-6904-1981

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Allosteric RegulationMajor topic
PiperidinesMajor topic
Protein Tyrosine Phosphatase, Non-Receptor Type 11Major topic
PyrimidinesMajor topic
Humans
Mutation
Oncogene Proteins
Protein Conformation

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P41 GM103622NIGMS NIH HHSUnited StatesP41GM103622PubMed and NIHNIH RePORTER
R35 CA220340NCI NIH HHSUnited StatesR35CA220340PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,826,400The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.Trends Biochem Sci2003https://conductscience.org/library/papers/12826400PubMed
220,383,002Features and development of Coot.Acta Crystallogr D Biol Crystallogr2010https://conductscience.org/library/papers/20383002PubMed
326,365,186PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.Cell Rep2015https://conductscience.org/library/papers/26365186PubMed
425,003,231Therapeutic potential of targeting the oncogenic SHP2 phosphatase.J Med Chem2014https://conductscience.org/library/papers/25003231PubMed
530,186,742Off-target inhibition by active site-targeting SHP2 inhibitors.FEBS Open Bio2018https://conductscience.org/library/papers/30186742PubMed
619,461,840Phaser crystallographic software.J Appl Crystallogr2007https://conductscience.org/library/papers/19461840PubMed
712,717,436Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.Nat Genet2003https://conductscience.org/library/papers/12717436PubMed
824,157,548Genome engineering using the CRISPR-Cas9 system.Nat Protoc2013https://conductscience.org/library/papers/24157548PubMed
925,979,474WGE: a CRISPR database for genome engineering.Bioinformatics2015https://conductscience.org/library/papers/25979474PubMed
1027,347,692Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.J Med Chem2016https://conductscience.org/library/papers/27347692PubMed

1 to 10 of 30

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Cited by97

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 150 citations.

PMIDTitleJournalYearIn PapersSource
42,929,068Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations.Biochem J2026https://conductscience.org/library/papers/42929068PubMed
42,908,566Modulation of the sensitivity to ruxolitinib-mediated JAK2 inhibition by mutationally activated SHP2 exhibits cell context dependency in pre-clinical models of myeloproliferative neoplasms.bioRxiv2026https://conductscience.org/library/papers/42908566PubMed
42,860,404Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42860404PubMed
42,742,803Deciphering SHP-2 conformational switching via elastic network models and transfer entropy analysis.J Mol Model2026https://conductscience.org/library/papers/42742803PubMed
42,365,381Dual functional genomics reveals a broad and convergent landscape of asciminib resistance in BCR::ABL1.Genome Med2026https://conductscience.org/library/papers/42365381PubMed
42,310,679SHP2 as a pivotal modulator of the tumor microenvironment in gastrointestinal cancers: from mechanisms to targeted therapies.J Transl Med2026https://conductscience.org/library/papers/42310679PubMed
42,289,381Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2.ChemMedChem2026https://conductscience.org/library/papers/42289381PubMed
42,172,315Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants.Sci Adv2026https://conductscience.org/library/papers/42172315PubMed
42,033,018Mapping the SHP2 Allosteric Pocket With Target-Biased Covalent Fragments.Chembiochem2026https://conductscience.org/library/papers/42033018PubMed
41,959,461High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition.bioRxiv2026https://conductscience.org/library/papers/41959461PubMed

1 to 10 of 97

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Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
BTLA151,888PubTator's text mininghttps://conductscience.org/library/genes/151888NCBI Gene
DNASE11,773PubTator's text mininghttps://conductscience.org/library/genes/1773NCBI Gene
EGF1,950PubTator's text mininghttps://conductscience.org/library/genes/1950NCBI Gene
IRS13,667PubTator's text mininghttps://conductscience.org/library/genes/3667NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene
NFKB14,790PubTator's text mininghttps://conductscience.org/library/genes/4790NCBI Gene
NR0B28,431PubTator's text mininghttps://conductscience.org/library/genes/8431NCBI Gene
PDCD15,133PubTator's text mininghttps://conductscience.org/library/genes/5133NCBI Gene
POTEF728,378PubTator's text mininghttps://conductscience.org/library/genes/728378NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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