Paper · 42110550
Benzofuran compound from Sophora tonkinensis Gagnep suppresses nasopharyngeal carcinoma growth via PI3K/AKT/mTOR pathway: evidence from molecular dynamics simulation and in vitro experiments.
Wu P and 11 others. Front Pharmacol, 2026. Cited by 0 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Benzofuran compound from Sophora tonkinensis Gagnep suppresses nasopharyngeal carcinoma growth via PI3K/AKT/mTOR pathway: evidence from molecular dynamics simulation and in vitro experiments. Papers, record 42110550. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/42110550
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Paper
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- Title
- Benzofuran compound from Sophora tonkinensis Gagnep suppresses nasopharyngeal carcinoma growth via PI3K/AKT/mTOR pathway: evidence from molecular dynamics simulation and in vitro experiments.
- PubMed
Topics0
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Comments and corrections0
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References29
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 15,520,809 | Molecular mechanisms of caspase regulation during apoptosis. | Nat Rev Mol Cell Biol | 2004 | https://conductscience.org/library/papers/15520809 | PubMed |
| 2 | 14,698,180 | 4-Hydroxy-3-methyl-6-phenylbenzofuran-2-carboxylic acid ethyl ester derivatives as potent anti-tumor agents. | Bioorg Med Chem Lett | 2004 | https://conductscience.org/library/papers/14698180 | PubMed |
| 3 | 35,117,827 | T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway. | Transl Cancer Res | 2020 | https://conductscience.org/library/papers/35117827 | PubMed |
| 4 | 32,473,991 | Anticancer activities of phytoconstituents and their liposomal targeting strategies against tumor cells and the microenvironment. | Adv Drug Deliv Rev | 2020 | https://conductscience.org/library/papers/32473991 | PubMed |
| 5 | 15,027,865 | Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. | J Med Chem | 2004 | https://conductscience.org/library/papers/15027865 | PubMed |
| 6 | 33,304,472 | EGFR-rich extracellular vesicles derived from highly metastatic nasopharyngeal carcinoma cells accelerate tumour metastasis through PI3K/AKT pathway-suppressed ROS. | J Extracell Vesicles | 2020 | https://conductscience.org/library/papers/33304472 | PubMed |
| 7 | 31,951,313 | BF12, a Novel Benzofuran, Exhibits Antitumor Activity by Inhibiting Microtubules and the PI3K/Akt/mTOR Signaling Pathway in Human Cervical Cancer Cells. | Chem Biodivers | 2020 | https://conductscience.org/library/papers/31951313 | PubMed |
| 8 | 17,451,940 | Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids. | J Steroid Biochem Mol Biol | 2007 | https://conductscience.org/library/papers/17451940 | PubMed |
| 9 | 35,666,775 | Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases. | J Am Chem Soc | 2022 | https://conductscience.org/library/papers/35666775 | PubMed |
| 10 | 26,068,519 | Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats. | Xenobiotica | 2015 | https://conductscience.org/library/papers/26068519 | PubMed |
1 to 10 of 29
See all 29 referencesCited by0
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Genes7
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| AKT1 | 207 | PubTator's text mining | https://conductscience.org/library/genes/207 | NCBI Gene |
| BAX | 581 | PubTator's text mining | https://conductscience.org/library/genes/581 | NCBI Gene |
| BCL2 | 596 | PubTator's text mining | https://conductscience.org/library/genes/596 | NCBI Gene |
| CCNE1 | 898 | PubTator's text mining | https://conductscience.org/library/genes/898 | NCBI Gene |
| CDK2 | 1,017 | PubTator's text mining | https://conductscience.org/library/genes/1017 | NCBI Gene |
| MTOR | 2,475 | PubTator's text mining | https://conductscience.org/library/genes/2475 | NCBI Gene |
| PIK3CB | 5,291 | PubTator's text mining | https://conductscience.org/library/genes/5291 | NCBI Gene |
Drugs0
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Data0
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Data dates
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- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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