Paper458145

The alternative pathway C3/C5 convertase: chemical basis of factor B activation.

Lesavre PH and 3 others. J Immunol, 1979. Cited by 232 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. The alternative pathway C3/C5 convertase: chemical basis of factor B activation. Papers, record 458145. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/458145

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: The alternative pathway C3/C5 convertase: chemical basis of factor B activation.; PubMed
Journal: J Immunol; PubMed
Year: 1979; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/458145/; PubMed
The journal: https://conductscience.org/library/journal-index/2985117R; PubMed
Citations, by iCite: 232; iCite
Relative citation ratio, by iCite: 6.37; iCite
Revised in PubMed: 2020-06-25; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Lesavre PH	P H
2	Hugli TE	T E
3	Esser AF	A F
4	Müller-Eberhard HJ	H J

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Complement Activating Enzymes	Major topic
Complement Activation	Major topic
Complement C3-C5 Convertases	Major topic
Complement Factor B	Major topic
Complement Pathway, Alternative	Major topic
Enzyme Precursors	Major topic
Chemotaxis, Leukocyte
Complement Factor D
Dose-Response Relationship, Immunologic
Electrophoresis, Polyacrylamide Gel
Hemolysis
Humans

Source PubMed

Show 6 more topicsShow fewer topics

Cited by59

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 232 citations.

PMID	Title	Journal	Year	In Papers	Source
41,756,295	Complement profiling for treatment outcomes in pulmonary TB.	Front Immunol	2026	https://conductscience.org/library/papers/41756295	PubMed
40,237,516	Proteins of the SubB family provide multiple mechanisms of serum resistance in Yersinia pestis.	Emerg Microbes Infect	2025	https://conductscience.org/library/papers/40237516	PubMed
39,635,529	The complement system in lipid-mediated pathologies.	Front Immunol	2024	https://conductscience.org/library/papers/39635529	PubMed
36,178,657	Vitamin D deficiency leads to the abnormal activation of the complement system.	Immunol Res	2023	https://conductscience.org/library/papers/36178657	PubMed
34,769,442	Functional Identification of Complement Factor D and Analysis of Its Expression during GCRV Infection in Grass Carp (Ctenopharyngodon idella).	Int J Mol Sci	2021	https://conductscience.org/library/papers/34769442	PubMed
30,260,060	Ail provides multiple mechanisms of serum resistance to Yersinia pestis.	Mol Microbiol	2019	https://conductscience.org/library/papers/30260060	PubMed
28,900,700	Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions.	Semin Immunopathol	2018	https://conductscience.org/library/papers/28900700	PubMed
25,654,073	The lectin pathway of complement and rheumatic heart disease.	Front Pediatr	2014	https://conductscience.org/library/papers/25654073	PubMed
20,852,386	Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.	J Clin Invest	2010	https://conductscience.org/library/papers/20852386	PubMed
20,702,808	Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome.	Am J Physiol Regul Integr Comp Physiol	2010	https://conductscience.org/library/papers/20702808	PubMed
19,603,351	Fragment Bb in amniotic fluid: evidence for complement activation by the alternative pathway in women with intra-amniotic infection/inflammation.	J Matern Fetal Neonatal Med	2009	https://conductscience.org/library/papers/19603351	PubMed
19,454,698	The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.	J Immunol	2009	https://conductscience.org/library/papers/19454698	PubMed
17,261,605	Complement factor D, albumin, and immunoglobulin G anti-band 3 protein antibodies mimic serum in promoting rosetting of malaria-infected red blood cells.	Infect Immun	2007	https://conductscience.org/library/papers/17261605	PubMed
17,245,758	Chylomicron accelerates C3 tick-over by regulating the role of factor H, leading to overproduction of acylation stimulating protein.	J Clin Lab Anal	2007	https://conductscience.org/library/papers/17245758	PubMed
10,477,273	Production and functional activity of a recombinant von Willebrand factor-A domain from human complement factor B.	Biochem J	1999	https://conductscience.org/library/papers/10477273	PubMed
9,746,588	Mannan-specific immunoglobulin G antibodies in normal human serum accelerate binding of C3 to Candida albicans via the alternative complement pathway.	Infect Immun	1998	https://conductscience.org/library/papers/9746588	PubMed
8,092,994	Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation.	Biochem J	1994	https://conductscience.org/library/papers/8092994	PubMed
7,092,811	Isolation, characterization and N-terminal sequences of the CNBr-cleavage peptides from human complement Factor B. Localization of a free thiol group and a sequence defining the site cleaved by factor D.	Biochem J	1982	https://conductscience.org/library/papers/7092811	PubMed
6,916,710	The activation of the alternative pathway C3 convertase by human plasma kallikrein.	Immunology	1982	https://conductscience.org/library/papers/6916710	PubMed
6,915,077	Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes.	J Exp Med	1982	https://conductscience.org/library/papers/6915077	PubMed

Show 14 more cited byShow fewer cited bySee all 59 cited by

Genes4

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
C2	717	PubTator's text mining	https://conductscience.org/library/genes/717	NCBI Gene
CFB	629	PubTator's text mining	https://conductscience.org/library/genes/629	NCBI Gene
CFD	1,675	PubTator's text mining	https://conductscience.org/library/genes/1675	NCBI Gene
ERVK-3	100,862,689	PubTator's text mining	https://conductscience.org/library/genes/100862689	NCBI Gene

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

None in this release

Grants
Trials
Comments and corrections
References
Drugs
Data

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/458145

GET https://conductscience.org/api/papers/v1/458145/cited_by?page=2

API reference For AI assistants