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Paper · 6961402

Circular dichroism spectroscopy of heparin-antithrombin interactions.

Stone AL and 3 others. Proc Natl Acad Sci U S A, 1982. Cited by 74 papers, by iCite.

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ConductScience Library. Circular dichroism spectroscopy of heparin-antithrombin interactions. Papers, record 6961402. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/6961402

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Circular dichroism spectroscopy of heparin-antithrombin interactions.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1982
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
74
iCite
Relative citation ratio, by iCite
2.43
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stone ALA L
2Beeler DD
3Oosta GG
4Rosenberg RDR D

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AntithrombinsMajor topic
HeparinMajor topic
Binding Sites
Carbohydrate Sequence
Circular Dichroism
Molecular Weight
Oligosaccharides
Protein Conformation
Spectrophotometry, Ultraviolet
Structure-Activity Relationship

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
GM26625NIGMS NIH HHSUnited StatesP01GM026625PubMed and NIHNIH RePORTER
HL-28625NHLBI NIH HHSUnited StatesR01HL028625PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References20

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
15,817,721Fine structure in the near-ultraviolet circular dichroism and absorption spectra of tryptophan derivatives and chymotrypsinogen A at 77 degrees K.Biochemistry1969https://conductscience.org/library/papers/5817721PubMed
24,738,234The purification and mechanism of action of human antithrombin-heparin cofactor.J Biol Chem1973https://conductscience.org/library/papers/4738234PubMed
34,591,332Aromatic contributions to circular dichroism spectra of proteins.CRC Crit Rev Biochem1974https://conductscience.org/library/papers/4591332PubMed
41,267,803The separation of active and inactive forms of heparin.Biochem Biophys Res Commun1976https://conductscience.org/library/papers/1267803PubMed
51,278,445Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.FEBS Lett1976https://conductscience.org/library/papers/1278445PubMed
6836,327Evidence for a heparin-induced conformational change on antithrombin III.Biochem Biophys Res Commun1977https://conductscience.org/library/papers/836327PubMed
7410,640The size and shape of human and bovine antithrombin III.Eur J Biochem1977https://conductscience.org/library/papers/410640PubMed
8277,908Structure-function relationships of heparin species.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/277908PubMed
9687,588Binding of low-affinity and high-affinity heparin to antithrombin. Ultraviolet difference spectroscopy and circular dichroism studies.Biochemistry1978https://conductscience.org/library/papers/687588PubMed
10429,327Fractionation of low molecular weight heparin species and their interaction with antithrombin.J Biol Chem1979https://conductscience.org/library/papers/429327PubMed

1 to 10 of 20

See all 20 references

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 74 citations.

PMIDTitleJournalYearIn PapersSource
24,068,708The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.J Biol Chem2013https://conductscience.org/library/papers/24068708PubMed
20,524,207Multiple mechanisms for exogenous heparin modulation of vascular endothelial growth factor activity.J Cell Biochem2010https://conductscience.org/library/papers/20524207PubMed
6,721,831Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4.Biochem J1984https://conductscience.org/library/papers/6721831PubMed
6,330,171Natural anticoagulant mechanisms.J Clin Invest1984https://conductscience.org/library/papers/6330171PubMed
3,800,942The relative molecular mass dependence of the anti-factor Xa properties of heparin.Biochem J1986https://conductscience.org/library/papers/3800942PubMed
3,473,488Expression of functionally active human antithrombin III.Proc Natl Acad Sci U S A1987https://conductscience.org/library/papers/3473488PubMed
3,111,566The haemostatic function of the vascular endothelial cell.Blut1987https://conductscience.org/library/papers/3111566PubMed
2,948,492Biological implications of the structural, antithrombin affinity and anticoagulant activity relationships among vertebrate heparins and heparan sulphates.Biochem J1986https://conductscience.org/library/papers/2948492PubMed
2,529,852Effect of a heparan sulphate with high affinity for antithrombin III upon inactivation of thrombin and coagulation factor Xa.Biochem J1989https://conductscience.org/library/papers/2529852PubMed
2,263,629Cell mutants defective in synthesizing a heparan sulfate proteoglycan with regions of defined monosaccharide sequence.Proc Natl Acad Sci U S A1990https://conductscience.org/library/papers/2263629PubMed

Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
F102,159PubTator's text mininghttps://conductscience.org/library/genes/2159NCBI Gene
F22,147PubTator's text mininghttps://conductscience.org/library/genes/2147NCBI Gene
SERPINC1462PubTator's text mininghttps://conductscience.org/library/genes/462NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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