Paper8065321
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Wheat WH and 2 others. Mol Cell Biol, 1994. Cited by 43 papers, by iCite.
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ConductScience Library. Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Papers, record 8065321. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8065321
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics17
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Antigens, Polyomavirus Transforming | Major topic |
| Cyclic AMP Response Element-Binding Protein | Major topic |
| Gene Expression Regulation, Viral | Major topic |
| Animals | |
| Bucladesine | |
| Cyclic AMP | |
| Humans | |
| In Vitro Techniques | |
| Nuclear Proteins | |
| Phosphoprotein Phosphatases | |
| Phosphorylation | |
| Protein Phosphatase 1 | |
| Protein Phosphatase 2 | |
| Rats | |
| Signal Transduction | |
| Transcription, Genetic | |
| Tumor Cells, Cultured |
Source PubMed
Grants1
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by |
|---|---|---|---|---|
| GM 47117 | NIGMS NIH HHS | United States | R29GM047117 | PubMed and NIH |
Source NIH RePORTER
References50
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 2,987,671 | Transient gene expression control: effects of transfected DNA stability and trans-activation by viral early proteins. | Mol Cell Biol | 1985 | https://conductscience.org/library/papers/2987671 | PubMed |
| 2 | 6,319,019 | Activation of the SV40 late promoter: direct effects of T antigen in the absence of viral DNA replication. | Cell | 1984 | https://conductscience.org/library/papers/6319019 | PubMed |
| 3 | 2,993,862 | trans Activation of the simian virus 40 late transcription unit by T-antigen. | Mol Cell Biol | 1985 | https://conductscience.org/library/papers/2993862 | PubMed |
| 4 | 3,015,903 | Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. | J Biol Chem | 1986 | https://conductscience.org/library/papers/3015903 | PubMed |
| 5 | 3,026,642 | SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. | Cell | 1987 | https://conductscience.org/library/papers/3026642 | PubMed |
| 6 | 2,822,706 | Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone. | J Biol Chem | 1987 | https://conductscience.org/library/papers/2822706 | PubMed |
| 7 | 2,446,854 | Adenosine 3',5'-monophosphate mediates both the mitogenic effect of thyrotropin and its ability to amplify the response to insulin-like growth factor I in FRTL5 cells. | Endocrinology | 1988 | https://conductscience.org/library/papers/2446854 | PubMed |
| 8 | 2,827,008 | SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. | Mol Cell Biol | 1988 | https://conductscience.org/library/papers/2827008 | PubMed |
| 9 | 2,452,440 | Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. | Proc Natl Acad Sci U S A | 1988 | https://conductscience.org/library/papers/2452440 | PubMed |
| 10 | 2,900,470 | Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. | Nature | 1988 | https://conductscience.org/library/papers/2900470 | PubMed |
| 11 | 3,203,384 | trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. | Cell | 1988 | https://conductscience.org/library/papers/3203384 | PubMed |
| 12 | 2,850,490 | Requirement for the simian virus 40 small tumor antigen in tumorigenesis in transgenic mice. | Mol Cell Biol | 1988 | https://conductscience.org/library/papers/2850490 | PubMed |
| 13 | 2,539,663 | The cyclic AMP-mediated stimulation of cell proliferation. | Trends Biochem Sci | 1989 | https://conductscience.org/library/papers/2539663 | PubMed |
| 14 | 2,547,582 | Insulin-like growth factor-I potentiates thyrotropin stimulation of adenylyl cyclase in FRTL-5 cells. | Endocrinology | 1989 | https://conductscience.org/library/papers/2547582 | PubMed |
| 15 | 2,549,856 | The structure and regulation of protein phosphatases. | Annu Rev Biochem | 1989 | https://conductscience.org/library/papers/2549856 | PubMed |
| 16 | 2,550,144 | Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. | Cell | 1989 | https://conductscience.org/library/papers/2550144 | PubMed |
| 17 | 2,573,431 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | Cell | 1989 | https://conductscience.org/library/papers/2573431 | PubMed |
| 18 | 2,153,055 | Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. | Cell | 1990 | https://conductscience.org/library/papers/2153055 | PubMed |
| 19 | 2,300,049 | In vitro analysis of promoter elements regulating transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. | Mol Cell Biol | 1990 | https://conductscience.org/library/papers/2300049 | PubMed |
| 20 | 2,157,202 | Association of protein phosphatase 2A with polyoma virus medium tumor antigen. | Proc Natl Acad Sci U S A | 1990 | https://conductscience.org/library/papers/2157202 | PubMed |
Cited by11
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 43 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 20,824,729 | Protein phosphatases 1 and 2A are both required for long-term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo. | Hippocampus | 2011 | https://conductscience.org/library/papers/20824729 | PubMed |
| 16,224,536 | Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. | J Clin Invest | 2005 | https://conductscience.org/library/papers/16224536 | PubMed |
| 14,528,276 | Viruses and cancer: lessons from the human polyomavirus, JCV. | Oncogene | 2003 | https://conductscience.org/library/papers/14528276 | PubMed |
| 11,171,037 | Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. | Biochem J | 2001 | https://conductscience.org/library/papers/11171037 | PubMed |
| 10,629,058 | CREB activation induces adipogenesis in 3T3-L1 cells. | Mol Cell Biol | 2000 | https://conductscience.org/library/papers/10629058 | PubMed |
| 9,819,441 | Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A. | Mol Cell Biol | 1998 | https://conductscience.org/library/papers/9819441 | PubMed |
| 9,421,878 | Mechanisms of transcriptional regulation of cellular genes by SV40 large T- and small T-antigens. | Virus Genes | 1997 | https://conductscience.org/library/papers/9421878 | PubMed |
| 9,348,314 | Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. | J Exp Med | 1997 | https://conductscience.org/library/papers/9348314 | PubMed |
| 9,312,025 | Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation. | EMBO J | 1997 | https://conductscience.org/library/papers/9312025 | PubMed |
| 8,917,510 | Induction of cyclin D1 by simian virus 40 small tumor antigen. | Proc Natl Acad Sci U S A | 1996 | https://conductscience.org/library/papers/8917510 | PubMed |
| 7,575,450 | Serine/threonine protein phosphatases. | Biochem J | 1995 | https://conductscience.org/library/papers/7575450 | PubMed |
Genes4
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CREB1 | 1,385 | PubTator's text mining | https://conductscience.org/library/genes/1385 | NCBI Gene |
| LGALS4 | 3,960 | PubTator's text mining | https://conductscience.org/library/genes/3960 | NCBI Gene |
| PCK2 | 5,106 | PubTator's text mining | https://conductscience.org/library/genes/5106 | NCBI Gene |
| PTPA | 5,524 | PubTator's text mining | https://conductscience.org/library/genes/5524 | NCBI Gene |
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The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
None in this release
- Trials
- Comments and corrections
- Drugs
- Data
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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