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Paper · 9787135

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.

Chesi M and 5 others. Blood, 1998. Cited by 442 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Papers, record 9787135. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9787135

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.
PubMed
Journal
Blood
PubMed
Year
1998
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
442
iCite
Relative citation ratio, by iCite
7.24
iCite
Revised in PubMed
2022-04-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chesi MM
2Nardini EE
3Lim RSR S
4Smith KDK D
5Kuehl WMW M
6Bergsagel PLP L

Source PubMed

Topics32

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carrier ProteinsMajor topic
Cell Transformation, NeoplasticMajor topic
Chromosomes, Human, Pair 14Major topic
Chromosomes, Human, Pair 4Major topic
Genes, ImmunoglobulinMajor topic
High Mobility Group ProteinsMajor topic
Immunoglobulin Heavy ChainsMajor topic
Multiple MyelomaMajor topic
Oncogene Proteins, FusionMajor topic
Protein-Tyrosine KinasesMajor topic
Receptors, Fibroblast Growth FactorMajor topic
Repressor ProteinsMajor topic
Translocation, GeneticMajor topic
Amino Acid Sequence
DNA Primers
DNA, Neoplasm
Exons
Gene Expression Regulation, Neoplastic
Histone-Lysine N-Methyltransferase
Humans
Karyotyping
Male
Molecular Sequence Data
Poly A
Promoter Regions, Genetic
RNA Splicing
RNA, Messenger
RNA, Neoplasm
Receptor, Fibroblast Growth Factor, Type 3
Testis
Thymus Gland
Tumor Cells, Cultured

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
CA74265NCI NIH HHSUnited StatesK01CA074265PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in11,510,469The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance.https://conductscience.org/library/papers/11510469

Source PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by229

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 442 citations.

PMIDTitleJournalYearIn PapersSource
42,794,546NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting.Int J Mol Sci2026https://conductscience.org/library/papers/42794546PubMed
42,371,798NSD2 degradation remediates the oncogenic cistrome in t(4;14) multiple myeloma.Blood2026https://conductscience.org/library/papers/42371798PubMed
41,935,182Comparison of gene fusion detection algorithms reveals frequently overlooked driver fusions in hematologic malignancies.NPJ Precis Oncol2026https://conductscience.org/library/papers/41935182PubMed
41,462,004Ferroptosis in hematological malignancies: molecular mechanisms and therapeutic potential.Cell Oncol (Dordr)2025https://conductscience.org/library/papers/41462004PubMed
41,301,842NSD Family-Mediated H3K36 Methylation in Human Cancer: Mechanisms and Therapeutic Opportunities.Biomedicines2025https://conductscience.org/library/papers/41301842PubMed
41,299,174NSD2 targeting reverses plasticity and drug resistance in prostate cancer.Nature2026https://conductscience.org/library/papers/41299174PubMed
41,051,795Chromatin Regulatory Targets for Anticancer Therapeutics.Chem Rev2025https://conductscience.org/library/papers/41051795PubMed
40,586,874NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders.Cell Mol Life Sci2025https://conductscience.org/library/papers/40586874PubMed
40,518,115FGFs/FGFRs and neuroinflammatory diseases: mechanism, drug therapies and delivery systems.J Adv Res2025https://conductscience.org/library/papers/40518115PubMed
40,211,787The molecular landscape of AL amyloidosis.Br J Haematol2025https://conductscience.org/library/papers/40211787PubMed

1 to 10 of 229

See all 229 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
NSD27,468Swiss-Prot's referenceshttps://conductscience.org/library/genes/7468NCBI Gene
ALL1100,310,785PubTator's text mininghttps://conductscience.org/library/genes/100310785NCBI Gene
CDKN2A1,029PubTator's text mininghttps://conductscience.org/library/genes/1029NCBI Gene
FGFR32,261PubTator's text mininghttps://conductscience.org/library/genes/2261NCBI Gene
HRX7,974PubTator's text mininghttps://conductscience.org/library/genes/7974NCBI Gene
IGH3,492PubTator's text mininghttps://conductscience.org/library/genes/3492NCBI Gene
KMT2A4,297PubTator's text mininghttps://conductscience.org/library/genes/4297NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data3

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
GENBANKAF071593GENBANK
GENBANKAF071594GENBANK
GENBANKAF071595GENBANK

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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