Disease · EFO_0011052
hepatotoxicity
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. hepatotoxicity. Diseases, record EFO_0011052. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0011052
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
Drugs7
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| SILYMARIN | CHEMBL4630684 | Phase 2/3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| FISH OIL TRIGLYCERIDES | CHEMBL4297535 | Phase 2 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets | |
| METHOTREXATE | CHEMBL34259 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| OMEGA-3-ACID ETHYL ESTERS | CHEMBL1200711 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| ACETYLCYSTEINE | CHEMBL600 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| LEFLUNOMIDE | CHEMBL960 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| TERIFLUNOMIDE | CHEMBL973 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets2
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial | 2 | Dihydroorotate dehydrogenase inhibitor | Unknown | https://conductscience.org/library/genes/1723 | Drugs and targets |
| DHFR | Dihydrofolate reductase | 1 | Dihydrofolate reductase inhibitor | Phase 2 | https://conductscience.org/library/genes/1719 | Drugs and targets |
Trials5
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01325584 | Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Induced Hepatic Injury | Phase 2 | 12 | 2018-06-27 | Cancer, Hepatic Injury | FISH OIL TRIGLYCERIDES | Its record names the disease | ClinicalTrials.gov |
| NCT07388407 | Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis | 110 | Rhematoid Arthritis | LEFLUNOMIDE, TERIFLUNOMIDE | Its record names the disease | ClinicalTrials.gov | ||
| NCT02373579 | Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia | Phase 2 | 70 | Acute Lymphoblastic Leukemia | METHOTREXATE | Its record names the disease | ClinicalTrials.gov | |
| NCT05595109 | Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients | Phase 2/3 | 56 | Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity, Cognitive Impairment | SILYMARIN | Its record names the disease | ClinicalTrials.gov | |
| NCT02010034 | Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury | Not applicable | 15 | Liver Disease, Impaired Liver Function, Parenteral Nutrition Associated Liver Disease | FISH OIL TRIGLYCERIDES | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 26421385 | DERIVED | 1 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/EFO_0011052
GET https://conductscience.org/api/diseases/v1/EFO_0011052/drugs