Disease · HP_0000371
Acute otitis media
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Acute otitis media. Diseases, record HP_0000371. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0000371
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- Acute otitis media
- Open Targets ID
- HP_0000371
- Other names
- Acute middle ear infection
- Highest stage of its drugs
- Approval, for 2 of its 12 drugs, from TTD
Source Open Targets
Drugs12
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| CIPROFLOXACIN | CHEMBL8 | Small molecule | Approval | TTD | 2 | 1 | 1 | Drugs and targets |
| DEXAMETHASONE | CHEMBL384467 | Small molecule | Approval | TTD | 2 | 1 | 1 | Drugs and targets |
| AMOXICILLIN | CHEMBL1082 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| TELITHROMYCIN | CHEMBL1136 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| AZITHROMYCIN | CHEMBL529 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 1 | Drugs and targets |
| LEVOFLOXACIN | CHEMBL5315124 | Small molecule | Phase 3 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| CLARITHROMYCIN | CHEMBL1741 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| COLFOSCERIL PALMITATE | CHEMBL1200737 | Small molecule | Phase 2 | TTD | 2 | 1 | 1 | Drugs and targets |
| BENZOCAINE | CHEMBL278172 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| FAROPENEM MEDOXOMIL | CHEMBL1257070 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
1 to 10 of 12
See all 12 drugsTargets1
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes |
|---|---|---|---|---|---|
| NR3C1 | Glucocorticoid receptor | 1 | Glucocorticoid receptor agonist | Approval | https://conductscience.org/library/genes/2908 |
Source Drugs and targets
Trials12
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT02567825 | Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media | Not applicable | 250 | 2021-12-10 | Acute Otitis Media | AMOXICILLIN, CEFTRIAXONE, OFLOXACIN | Its record names the disease | ClinicalTrials.gov |
| NCT03766373 | Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media | Phase 1 | 24 | 2019-11-21 | Acute Otitis Media | COLFOSCERIL PALMITATE | Its record names the disease | ClinicalTrials.gov |
| NCT00051753 | Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media | Phase 3 | 1,643 | Otitis Media | AMOXICILLIN, LEVOFLOXACIN | Its record names the disease | ClinicalTrials.gov | |
| NCT00315003 | TELI COM - Telithromycin in Children With Otitis Media | Phase 3 | 1,500 | Otitis Media, Suppurative, Otitis Media, Purulent | AZITHROMYCIN, TELITHROMYCIN | Its record names the disease | ClinicalTrials.gov | |
| NCT00174811 | Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections | Phase 3 | 639 | Otitis Media | TELITHROMYCIN | Its record names the disease | ClinicalTrials.gov | |
| NCT00276042 | A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media | Phase 2 | 328 | Otitis Media | FAROPENEM MEDOXOMIL | Its record names the disease | ClinicalTrials.gov | |
| NCT01027494 | Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora | 318 | Acute Otitis Media | CIPROFLOXACIN, DEXAMETHASONE | Its record names the disease | ClinicalTrials.gov | ||
| NCT04016051 | Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections | Phase 3 | 265 | Otitis Media, Tonsillitis, Pharyngitis, Bronchitis | CLARITHROMYCIN | Its record names the disease | ClinicalTrials.gov | |
| NCT00044473 | A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat | Phase 3 | 206 | Otitis Media | LEVOFLOXACIN | Its record names the disease | ClinicalTrials.gov | |
| NCT01244581 | Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry | Phase 3 | 84 | Otitis Media, Suppurative | AMOXICILLIN | Its record names the disease | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsComparisons in its trials5
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Surgical Management vs Non-Surgical Management: deaths from any cause | 0 of 129 | 0 of 121 | 250 | NCT02567825 | Trial comparisons |
| Surgical Management vs Non-Surgical Management: serious adverse events | 3 of 129 | 7 of 121 | 250 | NCT02567825 | Trial comparisons |
| Drug: OP0201 vs Drug: Placebo: Number of Participants With Adverse Events | 2 of 12 | 6 of 12 | 24 | NCT03766373 | Trial comparisons |
| Drug: OP0201 vs Drug: Placebo: deaths from any cause | 0 of 12 | 0 of 12 | 24 | NCT03766373 | Trial comparisons |
| Drug: OP0201 vs Drug: Placebo: serious adverse events | 0 of 12 | 0 of 12 | 24 | NCT03766373 | Trial comparisons |
Papers from its trials4
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/HP_0000371
GET https://conductscience.org/api/diseases/v1/HP_0000371/drugs