Disease · MONDO_0005892

otitis media with effusion

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. otitis media with effusion. Diseases, record MONDO_0005892. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005892

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: otitis media with effusion; Open Targets
Open Targets ID: MONDO_0005892; Open Targets
Other names: Glue ear, Mucoid otitis media, Mucoid otitis media NOS (disorder), OME, Otitis media with effusion - mucoid, Otitis media, transudative, Secretory Otitis Media, Transudative otitis media; Open Targets
MeSH: D010034; MeSH
NCI Thesaurus: C34886; NCI Thesaurus
Highest stage of its drugs: Phase 3, for 3 of its 7 drugs, from ClinicalTrials.gov; Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
MONTELUKAST	CHEMBL787	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
MOMETASONE	CHEMBL1201404	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
TRIAMCINOLONE ACETONIDE	CHEMBL1504	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
XYLITOL	CHEMBL96783	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
MOMETASONE FUROATE	CHEMBL1161	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
PREDNISOLONE SODIUM PHOSPHATE	CHEMBL1201014	Small molecule	Early phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
LANSOPRAZOLE	CHEMBL480	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	3	Glucocorticoid receptor agonist	Phase 3	https://conductscience.org/library/genes/2908	Drugs and targets
ATP4A	Potassium-transporting ATPase	1	Potassium-transporting ATPase inhibitor	Unknown	https://conductscience.org/library/genes/495	Drugs and targets
ATP4B	Potassium-transporting ATPase	1	Potassium-transporting ATPase inhibitor	Unknown	https://conductscience.org/library/genes/496	Drugs and targets
CYSLTR1	Cysteinyl leukotriene receptor 1	1	Cysteinyl leukotriene receptor 1 antagonist	Phase 3	https://conductscience.org/library/genes/10800	Drugs and targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00279916	Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays	Phase 3	91	2011-08-15	Otitis Media, Serous, Negative Middle Ear Pressure, Rhinitis, Otitis Media With Effusion, Otitis Media, Secretory	TRIAMCINOLONE ACETONIDE	Its record names the disease	ClinicalTrials.gov
NCT00546117	A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion	Not applicable	16	2011-01-11	Otitis Media With Effusion	LANSOPRAZOLE	Its record names the disease	ClinicalTrials.gov
NCT02541760	Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children	Phase 3	143		Otitis Media With Effiusion	MOMETASONE, MONTELUKAST	Its record names the disease	ClinicalTrials.gov
NCT03491098	The Efficacy of Nasal Steroids in Treatment of Otitis Media With Effusion: Acomparative Study	Early phase 1	60		Otitis Media With Effusion	MOMETASONE FUROATE, PREDNISOLONE SODIUM PHOSPHATE	Its record names the disease	ClinicalTrials.gov
NCT01967498	Montelukast for Children With Chronic Otitis Media With Effusion (COME): A Double-blind, Placebo-controlled Study	Not applicable	52		Chronic Otitis Media With Effusion, Conductive Hearing Loss	MONTELUKAST	Its record names the disease	ClinicalTrials.gov
NCT02950311	Xylitol for Otitis Media	Phase 2/3	0		Otitis Media With Effusion	XYLITOL	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials9

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Triamcinolone Acetonide vs Placebo: serious adverse events	0 of 45	0 of 41	86	NCT00279916	Trial comparisons
Triamcinolone Acetonide vs Placebo: Complete Normalization of Abnormal Tympanometry Considering the Subjects Who Took Additional Treatment as Having Incomplete Resolution	5 of 37	9 of 37	74	NCT00279916	Trial comparisons
Triamcinolone Acetonide vs Placebo: Number of Subjects With Complete Normalization of Abnormal Tympanometry, Regardless of Additional Treatment	7 of 37	12 of 37	74	NCT00279916	Trial comparisons
Prevacid vs Placebo: Absence of Middle Ear Fluid by Pneumatic Otoscopy, LeftEar	1 of 9	3 of 7	16	NCT00546117	Trial comparisons
Lansoprazole (Prevacid) vs Placebo: Number of Participants With at Least 1 Symptoms of Reflux in the Past Week, Assessed by the Reflux Symptom Questionnaire	0 of 9	0 of 7	16	NCT00546117	Trial comparisons
Lansoprazole (Prevacid) vs Placebo: Number of Participants With Normal Type A Tympanometry	0 of 9	0 of 7	16	NCT00546117	Trial comparisons
Prevacid vs Placebo: Absence of Middle Ear Fluid by Pneumatic Otoscopy, Right Ear	1 of 9	0 of 7	16	NCT00546117	Trial comparisons
Prevacid vs Placebo: deaths from any cause	0 of 9	0 of 7	16	NCT00546117	Trial comparisons
Prevacid vs Placebo: serious adverse events	0 of 9	0 of 7	16	NCT00546117	Trial comparisons

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
21576556	RESULT	1	PubMed
38088821	DERIVED	2	PubMed
28894551	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005892

GET https://conductscience.org/api/diseases/v1/MONDO_0005892/drugs

API reference For AI assistants