Disease · MONDO_0015469

craniosynostosis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. craniosynostosis. Diseases, record MONDO_0015469. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0015469

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: craniosynostosis; Open Targets
Open Targets ID: MONDO_0015469; Open Targets
Other names: craniosynostosis syndrome, premature closure of cranial sutures; Open Targets
Disease Ontology: DOID:2340; Disease Ontology
MeSH: D003398; MeSH
NCI Thesaurus: C84655; NCI Thesaurus
Orphanet: ORPHA:1531; Orphanet
Highest stage of its drugs: Phase 3, for 1 of its 4 drugs, from ClinicalTrials.gov; Open Targets

Drugs4

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TRANEXAMIC ACID	CHEMBL877	Small molecule	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
AMINOCAPROIC ACID	CHEMBL1046	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
FERRIC CARBOXYMALTOSE	CHEMBL2108597		Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
FERROUS FUMARATE	CHEMBL1200640	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets2

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PLG	Plasminogen	2	Plasminogen inhibitor	Phase 3	https://conductscience.org/library/genes/5340	Drugs and targets
PLAT	Tissue-type plasminogen activator	1	Tissue-type plasminogen activator inhibitor	Phase 2	https://conductscience.org/library/genes/5327	Drugs and targets

Trials4

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01813058	Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?	Phase 1/2	120	2019-02-20	Adolescent Idiopathic Scoliosis	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT03231085	Comparison of the Rate of Preoperative Haemoglobin After Administration of Epoetin Alpha Associated With an Oral Medical Supplementation Versus Intravenous Before Surgery of Craniosynostosis at the Child	Not applicable	100		Craniosynostosis	FERRIC CARBOXYMALTOSE, FERROUS FUMARATE	Its record names the disease	ClinicalTrials.gov
NCT01094977	Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid	Phase 3	90		Craniosynostoses	TRANEXAMIC ACID	Its record names the disease	ClinicalTrials.gov
NCT02229968	Efficacy of Amicar for Children Having Craniofacial Surgery	Phase 2	22		Craniosynostosis	AMINOCAPROIC ACID	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials2

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Tranexamic Acid vs Placebo: deaths from any cause	0 of 56	0 of 55	111	NCT01813058	Trial comparisons
Tranexamic Acid vs Placebo: serious adverse events	0 of 56	0 of 55	111	NCT01813058	Trial comparisons

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
23371895	RESULT	1	PubMed
21364458	RESULT	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0015469

GET https://conductscience.org/api/diseases/v1/MONDO_0015469/drugs

API reference For AI assistants