Disease · MONDO_0044339

lumbar disk degenerative disorder

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. lumbar disk degenerative disorder. Diseases, record MONDO_0044339. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0044339

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: lumbar disk degenerative disorder; Open Targets
Open Targets ID: MONDO_0044339; Open Targets
Other names: degeneration of lumbar intervertebral disc, degeneration of lumbar intervertebral disk, intervertebral disc degenerative disorder of lumbar region of vertebral column, intervertebral disc disease, susceptibility to, intervertebral disk degenerative disorder of lumbar region of vertebral column, intervertebral disk disease, susceptibility to, lumbar Disc Degeneration, lumbar Disc degenerative disease, lumbar Disc degenerative disorder, lumbar disc disease, susceptibility to, lumbar disk disease, susceptibility to, lumbar region of vertebral column intervertebral disc degenerative disorder, lumbar region of vertebral column intervertebral disk degenerative disorder; Open Targets
MeSH: C535531; MeSH
NCI Thesaurus: C27154; NCI Thesaurus
Highest stage of its drugs: Phase 2, for 2 of its 3 drugs, from ClinicalTrials.gov; Open Targets

Drugs3

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
RADOTERMIN	CHEMBL2108637	Protein	Phase 2	ClinicalTrials.gov	4	4	4	Drugs and targets
ABALOPARATIDE	CHEMBL3301581	Protein	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
REBONUPUTEMCEL	CHEMBL4802266	Cell	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets1

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes
PTH1R	Parathyroid hormone/parathyroid hormone-related peptide receptor	1	Parathyroid hormone receptor agonist	Phase 2	https://conductscience.org/library/genes/5745

Source Drugs and targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT01158924	A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration	Phase 1/2	40	2016-01-27	Early Lumbar Disc Degeneration	RADOTERMIN	Its record names the disease	ClinicalTrials.gov
NCT00813813	Intradiscal rhGDF-5 Phase I/II Clinical Trial	Phase 1/2	32	2016-01-27	Degenerative Disc Disease	RADOTERMIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT01182337	A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration	Phase 1/2	31	2016-01-27	Early Lumbar Disc Degeneration	RADOTERMIN	Its record names the disease	ClinicalTrials.gov
NCT01124006	A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration	Phase 2	24	2016-02-24	Degenerative Disc Disease	RADOTERMIN	Its record names the disease	ClinicalTrials.gov
NCT03955315	Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration	Phase 1	38		Degenerative Disc Disease	REBONUPUTEMCEL	Open Targets' reading of its record	ClinicalTrials.gov
NCT03708926	Effect of Abaloparatide on Lumbar Disc Degeneration	Phase 2	0		Degeneration Disc Intervertebral	ABALOPARATIDE	Open Targets' reading of its record	ClinicalTrials.gov

Comparisons in its trials10

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Intradiscal rhGDF-5 (1.0mg) vs Intradiscal rhGDF-5 (2.0mg): Treatment Emergent Adverse Events- Relationship to Study Drug	2 of 14	1 of 26	40	NCT01158924	Trial comparisons
Intradiscal rhGDF-5 (1.0mg) vs Intradiscal rhGDF-5 (2.0mg): serious adverse events	1 of 14	4 of 26	40	NCT01158924	Trial comparisons
Intradiscal rhGDF-5 (1.0mg) vs Intradiscal rhGDF-5 (2.0mg): Neurological Assessment for Motor Function and Reflexes/Sensory	0 of 13	2 of 25	38	NCT01158924	Trial comparisons
Intradiscal rhGDF-5 (0.25mg) vs Intradiscal rhGDF-5 (1.0mg): Neurological Assessment for Motor Function and Reflexes/Sensory	0 of 7	0 of 25	32	NCT00813813	Trial comparisons
Intradiscal rhGDF-5 (0.25mg) vs Intradiscal rhGDF-5 (1.0mg): Treatment Emergent Adverse Events- Relationship to Study Drug	2 of 7	1 of 25	32	NCT00813813	Trial comparisons
Intradiscal rhGDF-5 (0.25mg) vs Intradiscal rhGDF-5 (1.0mg): serious adverse events	2 of 7	2 of 25	32	NCT00813813	Trial comparisons
Intradiscal rhGDF-5 vs Vehicle Control: Treatment Emergent Adverse Events- Relationship to Study Drug	0 of 22	1 of 9	31	NCT01182337	Trial comparisons
Intradiscal rhGDF-5 1.0mg vs Vehicle Control: Treatment Emergent Adverse Events- Relationship to Study Drug	0 of 22	0 of 9	31	NCT01182337	Trial comparisons
Intradiscal rhGDF-5 vs Vehicle Control: serious adverse events	5 of 22	2 of 9	31	NCT01182337	Trial comparisons
Intradiscal rhGDF-5 1.0mg vs Vehicle Control: Neurological Assessment for Motor Function and Reflexes/Sensory	0 of 21	0 of 5	26	NCT01182337	Trial comparisons

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
33945627	DERIVED	1	PubMed
31442616	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0044339

GET https://conductscience.org/api/diseases/v1/MONDO_0044339/drugs

API reference For AI assistants