Drug · CHEMBL1237132
CLEVIDIPINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. CLEVIDIPINE. Drugs and targets, record CHEMBL1237132. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL1237132
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
Targets4
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| CACNA1C | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel blocker | BLOCKER | https://conductscience.org/library/genes/775 |
| CACNA1D | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel blocker | BLOCKER | https://conductscience.org/library/genes/776 |
| CACNA1F | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel blocker | BLOCKER | https://conductscience.org/library/genes/778 |
| CACNA1S | Voltage-gated L-type calcium channel | Voltage-gated L-type calcium channel blocker | BLOCKER | https://conductscience.org/library/genes/779 |
Source ChEMBL
Diseases8
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| hypertensive disorder | Approval | TTD | 14 | 13 | https://conductscience.org/library/drugs?q=MONDO_0005044 |
| malignant hypertension | Phase 3 | ClinicalTrials.gov | 4 | 4 | https://conductscience.org/library/drugs?q=MONDO_0006846 |
| intracerebral hemorrhage | Phase 3 | ClinicalTrials.gov | 2 | 2 | https://conductscience.org/library/drugs?q=MONDO_0013792 |
| Aortic dissection | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0002647 |
| aortic aneurysm | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005160 |
| stroke disorder | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005098 |
| subarachnoid hemorrhage | Phase 2 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0005099 |
| cardiovascular disorder | Approval | ATC | 1 | 0 | https://conductscience.org/library/drugs?q=MONDO_0004995 |
Source Open Targets
Trials27
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 4 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT00803634 | Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO) | Phase 3 | 117 | 2014-08-19 | clevidipine | Its name | ClinicalTrials.gov |
| NCT01645111 | An Open-label Trial of Clevidipine for Controlled Hypotension During Spinal Fusion | Phase 2/3 | 50 | 2015-02-18 | clevidipine | Its name | ClinicalTrials.gov |
| NCT00666328 | Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) | Phase 3 | 37 | 2013-04-08 | clevidipine | Its name | ClinicalTrials.gov |
| NCT00799604 | Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT) | Phase 2 | 30 | 2014-06-04 | clevidipine | Its name | ClinicalTrials.gov |
| NCT00952081 | A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients | Phase 4 | 22 | 2013-10-30 | clevidipine | Its name | ClinicalTrials.gov |
| NCT01938547 | Assessment of Efficacy, Safety and Dosing of Clevidipine in Pediatric Participants Undergoing Surgery (PIONEER) | Phase 4 | 22 | 2025-04-17 | clevidipine | Its name | ClinicalTrials.gov |
| NCT00978822 | Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage | Phase 2 | 5 | 2023-02-28 | clevidipine | Its name | ClinicalTrials.gov |
| NCT00093912 | Clevidipine in the Perioperative Treatment of Hypertension (ECLISPE-SNP) | Phase 3 | 739 | clevidipine | Its name | ClinicalTrials.gov | |
| NCT00093925 | Clevidipine in the Postoperative Treatment of Hypertension (ECLIPSE-NIC) | Phase 3 | 739 | clevidipine | Its name | ClinicalTrials.gov | |
| NCT00093886 | Clevidipine in the Perioperative Treatment of Hypertension (ECLIPSE-NTG) | Phase 3 | 629 | clevidipine | Its name | ClinicalTrials.gov |
1 to 10 of 27
See all 27 trialsComparisons in its trials1
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial |
|---|---|---|---|---|
| Clevidipine vs Standard of Care: serious adverse events | 12 of 51 | 10 of 53 | 104 | NCT00803634 |
Source Trial comparisons
Papers from its trials6
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials0
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
None in this release.
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL1237132
GET https://conductscience.org/api/drugs/v1/CHEMBL1237132/trials?page=2