Drug · CHEMBL440464
(+/-)NICOTINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. (+/-)NICOTINE. Drugs and targets, record CHEMBL440464. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL440464
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
Targets0
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
None in this release.
Diseases53
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 53Source Open Targets
See all 53 diseasesTrials612
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 13 more rest on that reading alone and are shown because the trials' posted result groups or NLM's indexing of their papers name the drug. 9 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT00356993 | Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP) | 6,009 | 2019-05-02 | nicotine | Its name | ClinicalTrials.gov | |
| NCT01574703 | Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. | Phase 4 | 4,595 | 2016-12-29 | nicotine | Its name | ClinicalTrials.gov |
| NCT00851357 | Telephone Counseling and the Distribution of Nicotine Patches to Smokers | Phase 3 | 4,200 | 2020-02-10 | nicotine | Its name | ClinicalTrials.gov |
| NCT01502306 | A Randomized Trial of Medi-Cal Beneficiaries Calling the California Smokers' Helpline | Phase 3 | 3,816 | 2019-10-01 | nicotine | Its name | ClinicalTrials.gov |
| NCT01736085 | Providing Free Nicotine Patches to Quitline Smokers | Phase 3 | 3,706 | 2020-02-19 | nicotine | Its name | ClinicalTrials.gov |
| NCT00775944 | Trial Comparing Different Methods of Support With Stopping Smoking (PORTSSS/Stop Together Trial) | Phase 4 | 2,591 | 2012-10-26 | nicotine | Its name | ClinicalTrials.gov |
| NCT00534404 | A Randomized Trial of Internet Access to Nicotine Patches | 2,485 | 2015-02-03 | nicotine | Its name | ClinicalTrials.gov | |
| NCT00352781 | Stop Smoking Therapy for Ontario Patients | 1,767 | 2012-04-17 | nicotine | Its name | ClinicalTrials.gov | |
| NCT00332644 | Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms | Phase 4 | 1,504 | 2011-11-30 | nicotine | Its name | ClinicalTrials.gov |
| NCT03603496 | Post-Discharge Smoking Cessation Strategies: Helping HAND 4 | Phase 4 | 1,416 | 2022-05-05 | nicotine replacement therapy | Open Targets' reading, confirmed by the trial's result groups and NLM's indexing of its papers | ClinicalTrials.gov |
1 to 10 of 612
See all 612 trialsComparisons in its trials368
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Proactive Group vs Reactive Group: serious adverse events | 16 of 649 | 6 of 649 | 1,298 | NCT00632411 | Trial comparisons |
| Nicotine vs Placebo: serious adverse events | 20 of 597 | 14 of 601 | 1,198 | NCT02355665 | Trial comparisons |
| Proactive Group vs Reactive Group: Continuous Abstinence | 173 of 521 | 136 of 529 | 1,050 | NCT00632411 | Trial comparisons |
| Opt Out vs Opt In: deaths from any cause | 27 of 655 | 19 of 345 | 1,000 | NCT02721082 | Trial comparisons |
| Opt Out vs Opt In: serious adverse events | 191 of 655 | 89 of 345 | 1,000 | NCT02721082 | Trial comparisons |
| Intervention vs Control: Number of Participants With Self-reported Tobacco Abstinence in Past 7 Days | 95 of 482 | 79 of 352 | 834 | NCT03717051 | Trial comparisons |
| Intervention vs Control: Number of Participants With Self-reported Use of NRT in Past Week/Month | 92 of 482 | 86 of 352 | 834 | NCT03717051 | Trial comparisons |
| Intervention vs Control: Number of Participants With Self-reported Quit Attempt | 214 of 482 | 153 of 352 | 834 | NCT03717051 | Trial comparisons |
| Intervention vs Control: Number of Participants With Self-reported Tobacco Abstinence in Past 7 Days | 104 of 482 | 92 of 352 | 834 | NCT03717051 | Trial comparisons |
| Intervention vs Control: Number of Participants Who Enroll in Any Smoking Cessation Service in Hong Kong | 156 of 482 | 158 of 352 | 834 | NCT03717051 | Trial comparisons |
1 to 10 of 368
See all 368 comparisons in its trialsPapers from its trials428
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials27
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome | Source |
|---|---|---|---|
| Continuous Performance Test | 9 | 5 | ConductCognition |
| 1-Back Task | 7 | 3 | ConductCognition |
| Purchase Task | 7 | 2 | ConductCognition |
| Stroop Color-Word Test | 6 | 5 | ConductCognition |
| 2-Back Task | 5 | 3 | ConductCognition |
| Food Cue Reactivity Task | 4 | 3 | ConductCognition |
| Go/No-Go Task | 4 | 2 | ConductCognition |
| Selective Reminding Task | 4 | 0 | ConductCognition |
| Verbal Fluency | 4 | 1 | ConductCognition |
| Antisaccade Task | 3 | 2 | ConductCognition |
1 to 10 of 27
See all 27 tests in its trialsData dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL440464
GET https://conductscience.org/api/drugs/v1/CHEMBL440464/diseases?page=2