Drug · CHEMBL548

DINOPROSTONE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. DINOPROSTONE. Drugs and targets, record CHEMBL548. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL548

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: DINOPROSTONE; ChEMBL
ChEMBL ID: CHEMBL548; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Cervidil, Prepidil, Propess, Prostin e2; ChEMBL
Other names: Dinoprostona, Dinoprostone beta-cyclodextrin clathrate, Enzaprost e, Minprostin e2, NSC-165560, NSC-196514, Prostaglandin e2, U-12,062, U-12062; ChEMBL
DrugBank: DB00917; DrugBank
InChIKey: XEYBRNLFEZDVAW-ARSRFYASSA-N; ChEMBL
Open Targets' highest stage: Approval, as Open Targets' drug record gives it; Open Targets

Targets4

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
PTGER1	Prostaglandin E2 receptor	Prostaglandin E2 receptor agonist	AGONIST	https://conductscience.org/library/genes/5731
PTGER2	Prostaglandin E2 receptor	Prostaglandin E2 receptor agonist	AGONIST	https://conductscience.org/library/genes/5732
PTGER3	Prostaglandin E2 receptor	Prostaglandin E2 receptor agonist	AGONIST	https://conductscience.org/library/genes/5733
PTGER4	Prostaglandin E2 receptor	Prostaglandin E2 receptor agonist	AGONIST	https://conductscience.org/library/genes/5734

Source ChEMBL

Diseases11

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=HP_0012531
Premature rupture of membranes	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=HP_0001788
fetal growth restriction	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0005030
pregnancy	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=EFO_0002950
Miscarriage	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0005268
Neonatal sepsis	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0040187
migraine without aura	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0100431
obesity disorder	Unknown	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0011122
oligohydramnios	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0005881
post term pregnancy	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0009681

1 to 10 of 11Source Open Targets

See all 11 diseases

Trials101

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT01127581	Efficacy & Safety Study Comparing Misoprostol Vaginal Insert (MVI) Versus Dinoprostone Vaginal Insert (DVI) for Reducing Time to Vaginal Delivery	Phase 3	1,358	2014-03-07	dinoprostone	Its name	ClinicalTrials.gov
NCT00308711	Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor	Phase 3	1,308	2010-02-19	dinoprostone	Its name	ClinicalTrials.gov
NCT01402050	Foley Catheter Versus Cervidil for Induction of Labor at Term		376	2020-02-06	dinoprostone	Its name	ClinicalTrials.gov
NCT01635439	Prostin and Propess in Induction of Labor	Phase 3	200	2012-10-04	dinoprostone	Its name	ClinicalTrials.gov
NCT01390233	Comparison of Pre-Induction Cervical Ripening		102	2014-05-30	prostaglandin E2	Its name	ClinicalTrials.gov
NCT03111316	Foley Catheter Compared to the Foley Catheter Alone for Cervical Ripening		100	2019-05-03	dinoprostone	Its name	ClinicalTrials.gov
NCT03806231	A Trial of Cervidil for Outpatient Pre-induction of Cervical Ripening	Phase 3	8	2021-09-05	dinoprostone	Its name	ClinicalTrials.gov
NCT02649920	Comparing the Efficiency of Cervical Ripening BALLoon (Cook) to the DINOprostone (Propess) for the Cervical Maturation in Case of Unfavorable Cervix (Bishop <6) in the Population of Obese Pregnant Women (BMI >= 30 kg/m²)		2	2024-08-15	dinoprostone	Its name	ClinicalTrials.gov
NCT01026948	Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM)		70	2012-01-06	dinoprostone	Its name	ClinicalTrials.gov
NCT02907060	Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies	Phase 3	1,224		dinoprostone	Its name	ClinicalTrials.gov

1 to 10 of 101

See all 101 trials

Comparisons in its trials8

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
MVI 200 vs Dinoprostone Vaginal Insert (DVI): serious adverse events	130 of 678	107 of 680	1,358	NCT01127581	Trial comparisons
FOLEY BALLOON vs CERVIDIL: serious adverse events	0 of 185	0 of 191	376	NCT01402050	Trial comparisons
Propess vs Prostin E2: Need for Syntocinon Augmentation	5 of 100	10 of 100	200	NCT01635439	Trial comparisons
Propess vs Prostin E2: Normal Vaginal Delivery Rate	79 of 100	85 of 100	200	NCT01635439	Trial comparisons
Propess vs Prostin E2: Uterine Hyper-stimulation Rate	1 of 100	1 of 100	200	NCT01635439	Trial comparisons
Propess vs Prostin E2: serious adverse events	1 of 100	2 of 100	200	NCT01635439	Trial comparisons
Outpatient Cervical Ripening vs Inpatient Cervical Ripening: deaths from any cause	0 of 4	0 of 4	8	NCT03806231	Trial comparisons
Outpatient Cervical Ripening vs Inpatient Cervical Ripening: serious adverse events	0 of 4	0 of 4	8	NCT03806231	Trial comparisons

Papers from its trials66

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37807591	RESULT	1	PubMed
34214801	RESULT	1	PubMed
34109770	RESULT	1	PubMed
33571294	RESULT	1	PubMed
33094550	RESULT	1	PubMed
32605542	RESULT	1	PubMed
32080050	RESULT	1	PubMed
31793372	RESULT	1	PubMed
29981523	RESULT	1	PubMed
29215519	RESULT	1	PubMed

1 to 10 of 66

See all 66 papers from its trials

Tests in its trials0

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL548

GET https://conductscience.org/api/drugs/v1/CHEMBL548/trials?page=2

API reference For AI assistants