Drug · CHEMBL70
MORPHINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. MORPHINE. Drugs and targets, record CHEMBL70. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL70
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
Anhydrous morphine, Hydromorphone hydrochloride impurity, morphine-, IDS-NM-009, Morphia, Morphine (anhydrous), Morphine anhydrous, Morphine extended release, Morphine polistirex, Morphium, N02AA01, Nepenthe, Ospalivina
- ChEMBL
Targets1
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| OPRM1 | Mu-type opioid receptor | Mu opioid receptor agonist | AGONIST | https://conductscience.org/library/genes/4988 |
Source ChEMBL
Diseases55
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| Pain | Approval | ATC | 71 | 68 | https://conductscience.org/library/drugs?q=HP_0012531 |
| cancer pain | Phase 3 | ClinicalTrials.gov | 15 | 15 | https://conductscience.org/library/drugs?q=EFO_0801084 |
| opiate dependence | Phase 3 | ClinicalTrials.gov | 6 | 6 | https://conductscience.org/library/drugs?q=MONDO_0005530 |
| renal colic | Phase 3 | ClinicalTrials.gov | 6 | 6 | https://conductscience.org/library/drugs?q=EFO_1001412 |
| Chronic pain | Approval | TTD | 6 | 5 | https://conductscience.org/library/drugs?q=HP_0012532 |
| cancer | Phase 3 | ClinicalTrials.gov | 5 | 5 | https://conductscience.org/library/drugs?q=MONDO_0004992 |
| neonatal abstinence syndrome | Phase 3 | ClinicalTrials.gov | 5 | 5 | https://conductscience.org/library/drugs?q=MONDO_0005566 |
| breast cancer | Phase 3 | ClinicalTrials.gov | 3 | 3 | https://conductscience.org/library/drugs?q=MONDO_0007254 |
| neuropathic pain | Phase 2 | ClinicalTrials.gov | 3 | 3 | https://conductscience.org/library/drugs?q=EFO_0005762 |
| osteoarthritis | Phase 2 | ClinicalTrials.gov | 3 | 3 | https://conductscience.org/library/drugs?q=MONDO_0005178 |
1 to 10 of 55Source Open Targets
See all 55 diseasesTrials734
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 4 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT02625181 | Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis | 27,034 | 2019-03-07 | morphine | Its name | ClinicalTrials.gov | |
| NCT00418457 | Regional Anesthesia and Breast Cancer Recurrence | Phase 3 | 2,108 | 2020-06-16 | morphine | Its name | ClinicalTrials.gov |
| NCT03726268 | Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) | Phase 4 | 907 | 2025-11-19 | morphine | Its name | ClinicalTrials.gov |
| NCT00478023 | A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy | Phase 3 | 854 | 2010-01-27 | morphine | Its name | ClinicalTrials.gov |
| NCT01809106 | RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. | Phase 4 | 518 | 2015-11-20 | morphine | Its name | ClinicalTrials.gov |
| NCT02064894 | Oral Analgesic Utilization for CHildhood Musculoskeletal Injuries | 501 | 2017-08-03 | morphine | Its name | ClinicalTrials.gov | |
| NCT02820324 | Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty | Phase 3 | 407 | 2020-10-23 | morphine | Its name | ClinicalTrials.gov |
| NCT02223377 | Satisfactory Analgesia Minimal Emesis in Day Surgeries | 402 | 2023-12-11 | morphine | Its name | ClinicalTrials.gov | |
| NCT01539538 | A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain | Phase 3 | 357 | 2014-03-27 | morphine | Its name | ClinicalTrials.gov |
| NCT03933397 | Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease | Phase 3 | 328 | 2023-07-03 | morphine | Its name | ClinicalTrials.gov |
1 to 10 of 734
See all 734 trialsComparisons in its trials194
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| General Anesthesia and Opioid vs Regional Analgesia and Propofol: Number of Participants Who Had Breast Cancer Recurrence After Breast Cancer Surgery | 111 of 1,065 | 102 of 1,043 | 2,108 | NCT00418457 | Trial comparisons |
| General Anesthesia and Opioid vs Regional Analgesia and Propofol: deaths from any cause | 22 of 1,065 | 18 of 1,043 | 2,108 | NCT00418457 | Trial comparisons |
| General Anesthesia and Opioid vs Regional Analgesia and Propofol: serious adverse events | 0 of 1,065 | 0 of 1,043 | 2,108 | NCT00418457 | Trial comparisons |
| Morphine vs Hydromorphone: Severe Respiratory Depression | 11 of 199 | 10 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: Number of Patients With Severe Itching | 2 of 199 | 5 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: Severe Sedation | 5 of 199 | 8 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | 172 of 199 | 175 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: deaths from any cause | 0 of 199 | 0 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: serious adverse events | 11 of 199 | 10 of 202 | 401 | NCT02223377 | Trial comparisons |
| Morphine vs Hydromorphone: Patients Requesting Oral Analgesia in the Day Surgery Unit | 128 of 194 | 135 of 199 | 393 | NCT02223377 | Trial comparisons |
1 to 10 of 194
See all 194 comparisons in its trialsPapers from its trials370
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials5
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome | Source |
|---|---|---|---|
| Card Sorting Test (Berg) | 1 | 0 | ConductCognition |
| Delay Discounting | 1 | 0 | ConductCognition |
| Psychomotor Vigilance Task | 1 | 0 | ConductCognition |
| Stroop Color-Word Test | 1 | 0 | ConductCognition |
| Symbol Coding | 1 | 0 | ConductCognition |
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL70
GET https://conductscience.org/api/drugs/v1/CHEMBL70/diseases?page=2