Drug · CHEMBL897

PROBENECID

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. PROBENECID. Drugs and targets, record CHEMBL897. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL897

On this page

Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: PROBENECID; ChEMBL
ChEMBL ID: CHEMBL897; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Benemid, Benuryl, Probalan, Probampicin, Probecid, Probenecid component of col-, Probenecid component of colbenemid, Probenecid component of orlynvah, Probenecid component of probampacin, Probenecid component of proben-c; ChEMBL
Other names: HC 5006, NSC-18786, P-(dipropylsulfamoyl)benzoic acid, Probenate, Probenecide, Probenecidum; ChEMBL
DrugBank: DB01032; DrugBank
InChIKey: DBABZHXKTCFAPX-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 2 of its 16 diseases, from ATC, DailyMed and TTD; Open Targets

Targets3

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
SLC22A11	Solute carrier family 22 member 11	Solute carrier family 22 member 11 inhibitor	INHIBITOR	https://conductscience.org/library/genes/55867
SLC22A6	Solute carrier family 22 member 6	Solute carrier family 22 member 6 inhibitor	INHIBITOR	https://conductscience.org/library/genes/9356
SLC22A8	Organic anion transporter 3	Solute carrier family 22 member 8 inhibitor	INHIBITOR	https://conductscience.org/library/genes/9376

Source ChEMBL

Diseases16

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
HIV infectious disease	Unknown	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0005109
cytomegalovirus retinitis	Unknown	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0000878
hypertensive disorder	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0005044
COVID-19	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0100096
Infertility	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0000789
alcohol dependence	Phase 1	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0007079
alcohol drinking	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=EFO_0004329
bacterial infectious disease	Phase 1	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0005113
cellulitis	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0005230
chondrocalcinosis	Early phase 1	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0001314

1 to 10 of 16Source Open Targets

See all 16 diseases

Trials58

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 1 more rests on that reading alone and is shown because the trial's posted result groups or NLM's indexing of its papers name the drug.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT05584657	Oral Sulopenem Versus Amoxicillin/Clavulanate for Uncomplicated Urinary Tract Infection in Adult Women	Phase 3	2,229	2024-11-20	sulopenem etzadroxil/probenecid	A combination that names it	ClinicalTrials.gov
NCT03354598	Oral Sulopenem-etzadroxil/Probenecid Versus Ciprofloxacin for Uncomplicated Urinary Tract Infection in Adult Women	Phase 3	1,671	2020-12-17	sulopenem-etzadroxil/probenecid	Open Targets' reading, confirmed by the trial's result groups	ClinicalTrials.gov
NCT03357614	Sulopenem Followed by Sulopenem-etzadroxil/Probenecid vs Ertapenem Followed by Cipro for Complicated UTI in Adults	Phase 3	1,395	2020-12-29	probenecid	Its name	ClinicalTrials.gov
NCT03358576	Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI)	Phase 3	674	2020-12-01	probenecid	Its name	ClinicalTrials.gov
NCT01320722	Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function	Phase 3	242	2017-06-29	probenecid	Its name	ClinicalTrials.gov
NCT01029782	Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis	Phase 2	206	2018-08-13	probenecid	Its name	ClinicalTrials.gov
NCT03296800	Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects	Phase 1	48	2021-04-27	probenecid	Its name	ClinicalTrials.gov
NCT03307252	This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men	Phase 1	45	2019-07-12	probenecid	Its name	ClinicalTrials.gov
NCT04218357	Probenecid as Medication for Alcohol Use Disorder (PROB)	Phase 1	35	2025-02-27	probenecid	Its name	ClinicalTrials.gov
NCT01021020	Bioequivalence Study of Colchicine Tablets	Phase 1	28	2009-11-26	probenecid	Its name	ClinicalTrials.gov

1 to 10 of 58

See all 58 trials

Comparisons in its trials33

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Probenecid vs Allopurinol: deaths from any cause	0 of 8,115	0 of 8,115	16,230	NCT04746989	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: Clinical Success Modified Intent-to-treat Population	851 of 1,107	849 of 1,107	2,214	NCT05584657	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: deaths from any cause	0 of 1,107	0 of 1,107	2,214	NCT05584657	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: serious adverse events	0 of 1,107	5 of 1,107	2,214	NCT05584657	Trial comparisons
Sulopenem vs Ertapenem: deaths from any cause	2 of 697	0 of 698	1,395	NCT03357614	Trial comparisons
Sulopenem vs Ertapenem: serious adverse events	14 of 697	6 of 698	1,395	NCT03357614	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: Microbiologic Success	390 of 522	315 of 468	990	NCT05584657	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: Overall Success	318 of 522	260 of 468	990	NCT05584657	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: Clinical Success	397 of 522	358 of 468	990	NCT05584657	Trial comparisons
Sulopenem Etzadroxil/Probenecid vs Amoxicillin/Clavulanate: Microbiologic Success Susceptible Population	361 of 480	295 of 442	922	NCT05584657	Trial comparisons

1 to 10 of 33

See all 33 comparisons in its trials

Papers from its trials27

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
39472130	RESULT	1	PubMed
31535696	RESULT	1	PubMed
28464732	RESULT	1	PubMed
19637952	RESULT	1	PubMed
18559644	RESULT	1	PubMed
11744606	RESULT	1	PubMed
10934667	RESULT	1	PubMed
10628898	RESULT	1	PubMed
40552968	DERIVED	1	PubMed
40401788	DERIVED	1	PubMed

1 to 10 of 27

See all 27 papers from its trials

Tests in its trials1

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome
Food Cue Reactivity Task	1	1

Source ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL897

GET https://conductscience.org/api/drugs/v1/CHEMBL897/trials?page=2

API reference For AI assistants