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Paper · 11069186

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.

Pellegrini L and 4 others. Nature, 2000. Cited by 576 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Papers, record 11069186. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/11069186

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.
PubMed
Journal
Nature
PubMed
Year
2000
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
576
iCite
Relative citation ratio, by iCite
11
iCite
Revised in PubMed
2024-04-22
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pellegrini LL
2Burke DFD F
3von Delft FF
4Mulloy BB
5Blundell TLT L

Source PubMed

Topics19

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fibroblast Growth Factor 2Major topic
HeparinMajor topic
Receptor Protein-Tyrosine KinasesMajor topic
Receptors, Fibroblast Growth FactorMajor topic
Amino Acid Sequence
Binding Sites
Crystallography, X-Ray
Escherichia coli
Fibroblast Growth Factor 1
Humans
Ligands
Macromolecular Substances
Models, Molecular
Molecular Sequence Data
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Receptor, Fibroblast Growth Factor, Type 2
Recombinant Proteins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by240

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 576 citations.

PMIDTitleJournalYearIn PapersSource
42,663,891FGF23 - A hormone produced by bone and has many faces.Rev Endocr Metab Disord2026https://conductscience.org/library/papers/42663891PubMed
42,559,254Reprogramming FGFR isoform specificity in FGF2 by deep mutational scanning.Chem Sci2026https://conductscience.org/library/papers/42559254PubMed
41,657,945Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioact Mater2026https://conductscience.org/library/papers/41657945PubMed
41,520,078Engineered fibroblast growth factor 1 variants uncouple glucose-lowering effects from mitogenic activity with therapeutic potential for type 2 diabetes.Mol Biomed2026https://conductscience.org/library/papers/41520078PubMed
41,245,879Heparan sulfate as a central modulator of growth factor dynamics in tissue regeneration.APL Bioeng2025https://conductscience.org/library/papers/41245879PubMed
40,779,638Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets.Sci Adv2025https://conductscience.org/library/papers/40779638PubMed
40,585,885High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice.J Endocr Soc2025https://conductscience.org/library/papers/40585885PubMed
40,497,953FGF-Mediated Axon Guidance: Role of Downstream Signaling Pathways in Cytoskeletal Control.Cells2025https://conductscience.org/library/papers/40497953PubMed
40,437,501Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor.Cell Commun Signal2025https://conductscience.org/library/papers/40437501PubMed
40,257,501Increased thermal stability of FGF10 leads to ectopic signaling during development.Cell Mol Life Sci2025https://conductscience.org/library/papers/40257501PubMed

1 to 10 of 240

See all 240 cited by

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
FGF12,246Swiss-Prot's referenceshttps://conductscience.org/library/genes/2246NCBI Gene
FGFR22,263Swiss-Prot's referenceshttps://conductscience.org/library/genes/2263NCBI Gene
GPC32,719PubTator's text mininghttps://conductscience.org/library/genes/2719NCBI Gene
MYB4,602PubTator's text mininghttps://conductscience.org/library/genes/4602NCBI Gene
RET5,979PubTator's text mininghttps://conductscience.org/library/genes/5979NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
PDB1E0O

Source PDB

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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