Paper · 17682002

Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease.

Kugathasan S and 8 others. Gut, 2007. Cited by 157 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Papers, record 17682002. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/17682002

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease.; PubMed
Journal: Gut; PubMed
Year: 2007; PubMed
Publication types: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/17682002/; PubMed
DOI: https://doi.org/10.1136/gut.2006.116467; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2095703/; PubMed
The journal: https://conductscience.org/library/journal-index/2985108R; PubMed
Citations, by iCite: 157; iCite
Relative citation ratio, by iCite: 3.31; iCite
Revised in PubMed: 2022-03-16; PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kugathasan S	S
2	Saubermann LJ	L J
3	Smith L	L
4	Kou D	D
5	Itoh J	J
6	Binion DG	D G
7	Levine AD	A D
8	Blumberg RS	R S
9	Fiocchi C	C

Source PubMed

Topics22

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Crohn Disease	Major topic
Intestinal Mucosa	Major topic
T-Lymphocyte Subsets	Major topic
Adolescent
Cells, Cultured
Child
Child, Preschool
Colon
Cytokines
Disease Progression
Female
Gene Expression Regulation
Humans
Immunity, Mucosal
Interferon-gamma
Interleukin-10
Interleukin-12 Subunit p40
Interleukin-4
Male
RNA, Messenger
Receptors, Interleukin-12
Th1 Cells

Source PubMed

Grants15

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R37 DK044319	NIDDK NIH HHS	United States	R01DK044319	PubMed and NIH	NIH RePORTER
DK51362	NIDDK NIH HHS	United States	R01DK051362	PubMed and NIH	NIH RePORTER
DK44319	NIDDK NIH HHS	United States	R01DK044319	PubMed and NIH	NIH RePORTER
R01 DK051362	NIDDK NIH HHS	United States	R01DK051362	PubMed and NIH	NIH RePORTER
R01 DK054213	NIDDK NIH HHS	United States	R01DK054213	PubMed and NIH	NIH RePORTER
P01 DK057756	NIDDK NIH HHS	United States	P01DK057756	PubMed and NIH	NIH RePORTER
DK30399	NIDDK NIH HHS	United States	R01DK030399	PubMed and NIH	NIH RePORTER
R37 DK030399	NIDDK NIH HHS	United States	R01DK030399	PubMed and NIH	NIH RePORTER
R01 DK050984	NIDDK NIH HHS	United States	R01DK050984	PubMed and NIH	NIH RePORTER
DK57756	NIDDK NIH HHS	United States	P01DK057756	PubMed and NIH	NIH RePORTER

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References67

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	11,095,340	Prolonged duration of response to infliximab in early but not late pediatric Crohn's disease.	Am J Gastroenterol	2000	https://conductscience.org/library/papers/11095340	PubMed
2	14,571,234	Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study.	J Pediatr	2003	https://conductscience.org/library/papers/14571234	PubMed
3	16,290,228	Understanding the IL-23-IL-17 immune pathway.	Trends Immunol	2006	https://conductscience.org/library/papers/16290228	PubMed
4	9,075,798	Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells.	Diabetes	1997	https://conductscience.org/library/papers/9075798	PubMed
5	17,635,957	Phenotypic and functional features of human Th17 cells.	J Exp Med	2007	https://conductscience.org/library/papers/17635957	PubMed
6	8,786,337	IL-12 unmasks latent autoimmune disease in resistant mice.	J Exp Med	1996	https://conductscience.org/library/papers/8786337	PubMed
7	17,101,325	Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis.	Gastroenterology	2006	https://conductscience.org/library/papers/17101325	PubMed
8	9,207,269	Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease.	Gastroenterology	1997	https://conductscience.org/library/papers/9207269	PubMed
9	16,670,765	The IL-23/IL-17 axis in inflammation.	J Clin Invest	2006	https://conductscience.org/library/papers/16670765	PubMed
10	16,424,940	Toll-like receptor 2 controls expansion and function of regulatory T cells.	J Clin Invest	2006	https://conductscience.org/library/papers/16424940	PubMed

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Cited by61

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 157 citations.

PMID	Title	Journal	Year	In Papers	Source
42,955,493	The Importance of Early (Effective) Interventions in Crohn's Disease: Current Concepts and Emerging Evidence.	Curr Gastroenterol Rep	2026	https://conductscience.org/library/papers/42955493	PubMed
42,012,779	Interleukin-23 Inhibitors in Inflammatory Bowel Disease.	BioDrugs	2026	https://conductscience.org/library/papers/42012779	PubMed
41,465,370	T Regulatory Cells in Inflammatory Bowel Disease-Are They Major Players?	Int J Mol Sci	2025	https://conductscience.org/library/papers/41465370	PubMed
40,620,305	Markers of bacterial translocation as a possible indicator of subclinical inflammation in pediatric inflammatory bowel diseases patients.	Prz Gastroenterol	2025	https://conductscience.org/library/papers/40620305	PubMed
38,233,198	Fibrosis in IBD: from pathogenesis to therapeutic targets.	Gut	2024	https://conductscience.org/library/papers/38233198	PubMed
37,047,398	Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System.	Int J Mol Sci	2023	https://conductscience.org/library/papers/37047398	PubMed
35,553,662	IL-23 Blockade in Anti-TNF Refractory IBD: From Mechanisms to Clinical Reality.	J Crohns Colitis	2022	https://conductscience.org/library/papers/35553662	PubMed
34,995,532	The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease.	Gastroenterology	2022	https://conductscience.org/library/papers/34995532	PubMed
34,638,616	Tumor Necrosis Factor's Pathway in Crohn's Disease: Potential for Intervention.	Int J Mol Sci	2021	https://conductscience.org/library/papers/34638616	PubMed
33,993,489	Novel mechanisms and clinical trial endpoints in intestinal fibrosis.	Immunol Rev	2021	https://conductscience.org/library/papers/33993489	PubMed

1 to 10 of 61

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Genes3

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
IFNG	3,458	PubTator's text mining	https://conductscience.org/library/genes/3458	NCBI Gene
IL12B	3,593	PubTator's text mining	https://conductscience.org/library/genes/3593	NCBI Gene
IL12RB2	3,595	PubTator's text mining	https://conductscience.org/library/genes/3595	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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