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Paper · 16670765

The IL-23/IL-17 axis in inflammation.

Iwakura Y and 1 other. J Clin Invest, 2006. Cited by 839 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The IL-23/IL-17 axis in inflammation. Papers, record 16670765. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16670765

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The IL-23/IL-17 axis in inflammation.
PubMed
Journal
J Clin Invest
PubMed
Year
2006
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
839
iCite
Relative citation ratio, by iCite
19.2
iCite
Revised in PubMed
2022-04-10
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Iwakura YYoichiro
2Ishigame HHarumichi

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
InflammationMajor topic
Interleukin-17Major topic
InterleukinsMajor topic
Animals
CD4-Positive T-Lymphocytes
Disease Models, Animal
Humans
Inflammatory Bowel Diseases
Interferon-gamma
Interleukin-23
Interleukin-23 Subunit p19
Interleukin-4
Models, Biological
Multiple Sclerosis
T-Lymphocytes, Helper-Inducer

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,473,830TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity2006https://conductscience.org/library/papers/16473830PubMed
216,410,834Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells.J Clin Invest2006https://conductscience.org/library/papers/16410834PubMed
316,415,102Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.Int Immunol2006https://conductscience.org/library/papers/16415102PubMed
416,157,683Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae.J Exp Med2005https://conductscience.org/library/papers/16157683PubMed
59,862,671IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.J Immunol1998https://conductscience.org/library/papers/9862671PubMed
612,721,360IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist.Proc Natl Acad Sci U S A2003https://conductscience.org/library/papers/12721360PubMed
712,220,546Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments.Cytokine Growth Factor Rev2002https://conductscience.org/library/papers/12220546PubMed
816,290,228Understanding the IL-23-IL-17 immune pathway.Trends Immunol2006https://conductscience.org/library/papers/16290228PubMed
911,086,043Microbial lipopeptides induce the production of IL-17 in Th cells.J Immunol2000https://conductscience.org/library/papers/11086043PubMed
1015,485,625Interleukin-17 family members and inflammation.Immunity2004https://conductscience.org/library/papers/15485625PubMed

1 to 10 of 29

See all 29 references

Cited by426

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 839 citations.

PMIDTitleJournalYearIn PapersSource
42,968,944Targeting the IL-23 pathway in inflammatory bowel disease: from cytokine inhibition to oral IL-23 receptor blockade.eGastroenterology2026https://conductscience.org/library/papers/42968944PubMed
42,941,268Differences in Serum Cytokine Profiles Between Vegetarians and Omnivores: Exploratory Assessment of Dietary Factors.Metabolites2026https://conductscience.org/library/papers/42941268PubMed
42,802,183Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nat Commun2026https://conductscience.org/library/papers/42802183PubMed
42,797,451CB2 Receptor Activation Attenuates IL-1β-Induced Inflammatory Transcriptomic Networks in Human Gingival Fibroblasts.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/42797451PubMed
42,730,866Protective effect of cannabinoid type 2 receptor agonist (JWH-133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract.Exp Physiol2026https://conductscience.org/library/papers/42730866PubMed
42,725,079Recovery-Primed Stimulation: A Proposed Framework for Controlled Triggering of Healing-Related Physiology in Low-Grade Chronic Inflammation.Cureus2026https://conductscience.org/library/papers/42725079PubMed
42,464,153An evaluation of cytokine responses and antiseizure medication levels during mild upper respiratory infections in children with epilepsy.BMC Pediatr2026https://conductscience.org/library/papers/42464153PubMed
42,445,195Impact of anti-TNF and anti-IL-12/IL-23 antibody therapy on periodontal inflammation and gingival crevicular fluid IL-6 in patients with inflammatory bowel diseases.Front Immunol2026https://conductscience.org/library/papers/42445195PubMed
42,370,082Understanding the transition from psoriasis to psoriatic arthritis: the role of targeted therapy.EULAR Rheumatol Open2026https://conductscience.org/library/papers/42370082PubMed
42,262,151Enhancing Preclinical Rigor: Evaluating Robustness and Numerical Stability in a Chronic Pancreatitis Mouse Model.Ann N Y Acad Sci2026https://conductscience.org/library/papers/42262151PubMed

1 to 10 of 426

See all 426 cited by

Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene
IL12B3,593PubTator's text mininghttps://conductscience.org/library/genes/3593NCBI Gene
IL17A3,605PubTator's text mininghttps://conductscience.org/library/genes/3605NCBI Gene
IL17F112,744PubTator's text mininghttps://conductscience.org/library/genes/112744NCBI Gene
IL23A51,561PubTator's text mininghttps://conductscience.org/library/genes/51561NCBI Gene
IL27246,778PubTator's text mininghttps://conductscience.org/library/genes/246778NCBI Gene
IL43,565PubTator's text mininghttps://conductscience.org/library/genes/3565NCBI Gene
IL63,569PubTator's text mininghttps://conductscience.org/library/genes/3569NCBI Gene
TNF7,124PubTator's text mininghttps://conductscience.org/library/genes/7124NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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