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Paper · 18601945

Regulation of glutathione synthesis.

Lu SC. Mol Aspects Med, 2009. Cited by 1,587 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Regulation of glutathione synthesis. Papers, record 18601945. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/18601945

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Regulation of glutathione synthesis.
PubMed
Journal
Mol Aspects Med
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Review
PubMed
Citations, by iCite
1,587
iCite
Relative citation ratio, by iCite
43.2
iCite
Revised in PubMed
2025-05-29
PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Lu SCShelly C

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
GlutathioneMajor topic
Animals
Glutamate-Cysteine Ligase
Glutathione Synthase
Humans
Models, Biological

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK045334NIDDK NIH HHSUnited StatesR01DK045334PubMed and NIHNIH RePORTER
R56 DK045334NIDDK NIH HHSUnited StatesR01DK045334PubMed and NIHNIH RePORTER
DK45334NIDDK NIH HHSUnited StatesR01DK045334PubMed and NIHNIH RePORTER
R29DK045334NIHNIH RePORTER
R56DK045334NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References183

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,486,302Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat.Toxicol Appl Pharmacol1999https://conductscience.org/library/papers/10486302PubMed
215,683,710Mechanisms of glutamate cysteine ligase (GCL) induction by 4-hydroxynonenal.Free Radic Biol Med2005https://conductscience.org/library/papers/15683710PubMed
37,775,566The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.J Cell Biol1995https://conductscience.org/library/papers/7775566PubMed
43,202,158Alpha-adrenergic modulation of glutathione metabolism in isolated rat hepatocytes.Am J Physiol1988https://conductscience.org/library/papers/3202158PubMed
516,585,964Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.J Clin Invest2006https://conductscience.org/library/papers/16585964PubMed
67,513,621Up-regulation of gamma-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels.Cancer Chemother Pharmacol1994https://conductscience.org/library/papers/7513621PubMed
710,977,039Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children.Diabetes Care2000https://conductscience.org/library/papers/10977039PubMed
814,978,233Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver.Mol Pharmacol2004https://conductscience.org/library/papers/14978233PubMed
914,871,475Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.Arch Biochem Biophys2004https://conductscience.org/library/papers/14871475PubMed
109,374,527Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.J Biol Chem1997https://conductscience.org/library/papers/9374527PubMed

1 to 10 of 183

See all 183 references

Cited by867

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,587 citations.

PMIDTitleJournalYearIn PapersSource
42,939,851N-Acetylcysteine in Schizophrenia: A Convergent Redox-Based Approach to Therapeutic Potential.Antioxidants (Basel)2026https://conductscience.org/library/papers/42939851PubMed
42,936,072SCOPE: A Spatial Co-registration and Omics Pipeline for Comparative Mass Spectrometry Imaging Data Analysis.Comput Struct Biotechnol J2026https://conductscience.org/library/papers/42936072PubMed
42,913,006NRF2 coordinates cystine import and glutathione use to sustain ferroptosis resistance and formaldehyde tolerance in cancer.Sci Adv2026https://conductscience.org/library/papers/42913006PubMed
42,856,235Multiomic Profiling Links RDH12-Dependent Retinaldehyde Detoxification to Membrane Remodeling and Ferroptosis.bioRxiv2026https://conductscience.org/library/papers/42856235PubMed
42,820,079
Comparative Protective Effects of ATP and TPP Against Olaparib-Induced Ovarian Injury in Rats: Insights from Biochemical Parameters, Histopathology, and IRE1α, Cleaved Caspase-3, LC3B, and NF-κB p65 Double Immunofluorescence.
Drug Des Devel Ther2026https://conductscience.org/library/papers/42820079PubMed
42,819,057From antidote to multimodal adjunct: a systematic review of N-acetylcysteine in dogs and cats.Front Vet Sci2026https://conductscience.org/library/papers/42819057PubMed
42,797,459Oxidative Stress as a Pathophysiological Core of Obesity: Preclinical Evidence for Antioxidant-Based Therapy Strategies.Pharmaceuticals (Basel)2026https://conductscience.org/library/papers/42797459PubMed
42,794,838Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.Int J Mol Sci2026https://conductscience.org/library/papers/42794838PubMed
42,792,562Glutathione Relevance in the Response of Ciliate Tetrahymena thermophila Against Metals/Metalloids and Other Environmental Stressors.Biology (Basel)2026https://conductscience.org/library/papers/42792562PubMed
42,792,126Skin Histology of Pithecopus spp. and Modulation of Glutathione Status by the Antioxidant Tryptophyllin PaT-2.Antioxidants (Basel)2026https://conductscience.org/library/papers/42792126PubMed

1 to 10 of 867

See all 867 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
GCLC2,729PubTator's text mininghttps://conductscience.org/library/genes/2729NCBI Gene
GCLM2,730PubTator's text mininghttps://conductscience.org/library/genes/2730NCBI Gene
GSS2,937PubTator's text mininghttps://conductscience.org/library/genes/2937NCBI Gene
JUNB3,726PubTator's text mininghttps://conductscience.org/library/genes/3726NCBI Gene
NFE2L24,780PubTator's text mininghttps://conductscience.org/library/genes/4780NCBI Gene
NFKB14,790PubTator's text mininghttps://conductscience.org/library/genes/4790NCBI Gene
NRF14,899PubTator's text mininghttps://conductscience.org/library/genes/4899NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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