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Paper · 19252484

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.

Chambers SM and 5 others. Nat Biotechnol, 2009. Cited by 2,879 papers, by iCite.

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ConductScience Library. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Papers, record 19252484. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/19252484

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
PubMed
Journal
Nat Biotechnol
PubMed
Year
2009
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
2,879
iCite
Relative citation ratio, by iCite
63.6
iCite
Revised in PubMed
2026-01-28
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chambers SMStuart M
2Fasano CAChristopher A
3Papapetrou EPEirini P
4Tomishima MMark
5Sadelain MMichel
6Studer LLorenz

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell DifferentiationMajor topic
Embryonic Stem CellsMajor topic
NeuronsMajor topic
Pluripotent Stem CellsMajor topic
Signal TransductionMajor topic
Smad ProteinsMajor topic
Carrier Proteins
Cell Culture Techniques
Humans
Mesencephalon
Noggin Protein

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 NS052671NINDS NIH HHSUnited StatesR01NS052671PubMed and NIH
1R01NS052671NINDS NIH HHSUnited StatesR01NS052671PubMed and NIH

Source NIH RePORTER

Trials1

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's record
NCT02980302Development of the Tool " iPSC " for the Functional Study of Mutations Responsible for Mental RetardationBackground

Source ClinicalTrials.gov

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References24

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,990,587Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library.Stem Cells2007https://conductscience.org/library/papers/16990587PubMed
28,001,117Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.Cell1994https://conductscience.org/library/papers/8001117PubMed
317,478,583Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.Stem Cells2007https://conductscience.org/library/papers/17478583PubMed
49,056,723PAX-6 in development and evolution.Annu Rev Neurosci1997https://conductscience.org/library/papers/9056723PubMed
517,597,760New cell lines from mouse epiblast share defining features with human embryonic stem cells.Nature2007https://conductscience.org/library/papers/17597760PubMed
618,682,241NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs.Cell Stem Cell2008https://conductscience.org/library/papers/18682241PubMed
718,035,408Induction of pluripotent stem cells from adult human fibroblasts by defined factors.Cell2007https://conductscience.org/library/papers/18035408PubMed
817,529,971A ROCK inhibitor permits survival of dissociated human embryonic stem cells.Nat Biotechnol2007https://conductscience.org/library/papers/17529971PubMed
917,721,512Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.Nat Biotechnol2007https://conductscience.org/library/papers/17721512PubMed
1018,157,115Reprogramming of human somatic cells to pluripotency with defined factors.Nature2008https://conductscience.org/library/papers/18157115PubMed

1 to 10 of 24

See all 24 references

Cited by2,090

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,879 citations.

PMIDTitleJournalYearIn PapersSource
42,970,714Precision cell therapy: optimizing neural stem/progenitor cell regional identity for enhanced spinal cord repair and regeneration.Stem Cells Transl Med2026https://conductscience.org/library/papers/42970714PubMed
42,969,231A rare TMEM175 mutation drives Parkinson's disease pathology by disrupting proton gating and lysosomal acidification.J Clin Invest2026https://conductscience.org/library/papers/42969231PubMed
42,939,869Mitochondrial Remodeling and Impaired Bioenergetics Define Neuronal Vulnerability in Fragile X-Related Disorders.Antioxidants (Basel)2026https://conductscience.org/library/papers/42939869PubMed
42,929,815Enhanced Synaptic-Related Transcriptional Programs in Human Forebrain Organoids for Modeling Synaptopathy-Associated Neurodevelopmental Disorders.Cells2026https://conductscience.org/library/papers/42929815PubMed
42,928,091Identification of substrates of the human mitochondrial ClpXP protease and its implications for Perrault syndrome.Nat Commun2026https://conductscience.org/library/papers/42928091PubMed
42,910,235Human Induced Pluripotent Stem Cells in Rare Neurological Disorders: Opportunities and Challenges for Disease Modeling and Drug Discovery.Stem Cells Int2026https://conductscience.org/library/papers/42910235PubMed
42,905,381A novel strategy to generate human iPSCs with enhanced mesodermal and endodermal differentiation capacity.Cell Regen2026https://conductscience.org/library/papers/42905381PubMed
42,878,089Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging.J Clin Invest2026https://conductscience.org/library/papers/42878089PubMed
42,871,576Patient-derived stem cell models of brain endothelial-neuron interactions in early course psychosis.Front Psychiatry2026https://conductscience.org/library/papers/42871576PubMed
42,857,333Strategies for Differentiation of Corneal Endothelial Cells From Stem Cells: Current Advances and Challenges.Stem Cells Int2026https://conductscience.org/library/papers/42857333PubMed

1 to 10 of 2,090

See all 2,090 cited by

Genes31

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACVR1B91PubTator's text mininghttps://conductscience.org/library/genes/91NCBI Gene
ACVR1C130,399PubTator's text mininghttps://conductscience.org/library/genes/130399NCBI Gene
B3GAT127,087PubTator's text mininghttps://conductscience.org/library/genes/27087NCBI Gene
BDNF627PubTator's text mininghttps://conductscience.org/library/genes/627NCBI Gene
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
CHRD8,646PubTator's text mininghttps://conductscience.org/library/genes/8646NCBI Gene
FGF52,250PubTator's text mininghttps://conductscience.org/library/genes/2250NCBI Gene
FGF82,253PubTator's text mininghttps://conductscience.org/library/genes/2253NCBI Gene
FOXG12,290PubTator's text mininghttps://conductscience.org/library/genes/2290NCBI Gene
FST10,468PubTator's text mininghttps://conductscience.org/library/genes/10468NCBI Gene

1 to 10 of 31

See all 31 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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